UniProtKB - O35716 (SOCS1_MOUSE)
Suppressor of cytokine signaling 1
Socs1
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central
- insulin-like growth factor receptor binding Source: MGI
- kinase inhibitor activity Source: MGI
- protein kinase binding Source: MGI
GO - Biological processi
- cellular response to amino acid stimulus Source: MGI
- cellular response to cytokine stimulus Source: MGI
- cellular response to organic cyclic compound Source: MGI
- cytokine-mediated signaling pathway Source: MGI
- fat cell differentiation Source: MGI
- intracellular signal transduction Source: InterPro
- negative regulation of CD8-positive, alpha-beta T cell differentiation Source: UniProtKB
- negative regulation of insulin receptor signaling pathway Source: MGI
- negative regulation of receptor signaling pathway via JAK-STAT Source: MGI
- negative regulation of tyrosine phosphorylation of STAT protein Source: MGI
- phosphatidylinositol phosphorylation Source: GO_Central
- positive regulation of CD4-positive, alpha-beta T cell differentiation Source: UniProtKB
- positive regulation of regulatory T cell differentiation Source: MGI
- protein ubiquitination Source: UniProtKB-UniPathway
- receptor signaling pathway via JAK-STAT Source: MGI
- regulation of activation of Janus kinase activity Source: MGI
- regulation of cytokine production Source: MGI
- regulation of growth Source: UniProtKB-KW
- regulation of interferon-gamma-mediated signaling pathway Source: InterPro
- regulation of protein phosphorylation Source: MGI
- regulation of receptor signaling pathway via JAK-STAT Source: MGI
- regulation of tyrosine phosphorylation of STAT protein Source: MGI
Keywordsi
Molecular function | Signal transduction inhibitor |
Biological process | Growth regulation, Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling R-MMU-877300, Interferon gamma signaling R-MMU-877312, Regulation of IFNG signaling R-MMU-909733, Interferon alpha/beta signaling R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SABIO-RKi | O35716 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Suppressor of cytokine signaling 1CuratedShort name: SOCS-1Curated Alternative name(s): JAK-binding protein Short name: JAB STAT-induced STAT inhibitor 11 Publication Short name: SSI-11 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1354910, Socs1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasmic vesicle By similarity
Note: Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.By similarity
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: MGI
Other locations
- cytoplasmic ribonucleoprotein granule Source: MGI
- cytoplasmic vesicle Source: UniProtKB-KW
- phosphatidylinositol 3-kinase complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasmic vesicle, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 51 | P → A: No effect on LIF signal transduction suppression. | 1 | |
Mutagenesisi | 52 | G → A: No effect on LIF signal transduction suppression. | 1 | |
Mutagenesisi | 53 | D → A or R: No effect on LIF signal transduction suppression. | 1 | |
Mutagenesisi | 54 | T → A: No effect on LIF signal transduction suppression. | 1 | |
Mutagenesisi | 55 | H → A or D: No effect on JAK signal transduction suppression. 1 Publication | 1 | |
Mutagenesisi | 56 | F → A, S or D: Loss of JAK signal transduction suppression. 1 Publication | 1 | |
Mutagenesisi | 56 | F → E or S: Reduced binding to JH1. 1 Publication | 1 | |
Mutagenesisi | 56 | F → L: No effect on JAK signal transduction inhibition nor on binding to JH1. 1 Publication | 1 | |
Mutagenesisi | 57 | R → A or E: No effect on JAK signal transduction suppression. 1 Publication | 1 | |
Mutagenesisi | 58 | T → A: No effect on JAK signal transduction suppression. 1 Publication | 1 | |
Mutagenesisi | 59 | F → A or E: Loss of JAK signal transduction suppression. Reduced binding to JH1. 2 Publications | 1 | |
Mutagenesisi | 59 | F → D: Loss of JAK signal transduction suppression. Destabilization of SOCS1. 2 Publications | 1 | |
Mutagenesisi | 59 | F → L: No effect on JAK signal transduction suppression nor on binding to JH1. 2 Publications | 1 | |
Mutagenesisi | 60 | R → A: No effect on LIF signal transduction suppression. 1 Publication | 1 | |
Mutagenesisi | 61 | S → E: No effect on JAK signal transduction suppression. 1 Publication | 1 | |
Mutagenesisi | 62 | H → E: No effect on JAK signal transduction suppression. 1 Publication | 1 | |
Mutagenesisi | 64 | D → R: Loss of JAK signal transduction suppression. Reduced binding to JH1. 1 Publication | 1 | |
Mutagenesisi | 65 | Y → A: Some loss of JAK signal transduction signaling. Reduced binding to JH1. 1 Publication | 1 | |
Mutagenesisi | 68 | I → E: Loss of binding to JH1/Y-1007 of JAK2 and loss of signal transduction suppression. | 1 | |
Mutagenesisi | 70 | R → E: No effect on LIF signal transduction suppression. | 1 | |
Mutagenesisi | 75 | L → E: Loss of binding to JH1/Y-1007 of JAK2 and loss of signal transduction suppression. | 1 | |
Mutagenesisi | 105 | R → K: Loss of LIF signal transduction suppression. Loss of binding to KIT. No effect on binding to VAV. 1 Publication | 1 | |
Mutagenesisi | 105 | R → Q: Loss of IL-6 signal transduction suppression. No effect on binding to TYK2. 1 Publication | 1 | |
Mutagenesisi | 175 | L → P: Abolishes interaction with elongin BC complex; when associated with F-179. 1 Publication | 1 | |
Mutagenesisi | 179 | C → F: Abolishes interaction with elongin BC complex; when associated with P-175. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181236 | 1 – 212 | Suppressor of cytokine signaling 1Add BLAST | 212 |
Proteomic databases
EPDi | O35716 |
PaxDbi | O35716 |
PRIDEi | O35716 |
ProteomicsDBi | 257284 |
PTM databases
iPTMneti | O35716 |
PhosphoSitePlusi | O35716 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000038037, Expressed in thymus and 65 other tissues |
Genevisiblei | O35716, MM |
Interactioni
Subunit structurei
Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domain to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV.
Interacts with the Elongin BC complex (ELOB and ELOC).
Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1.
Interacts (via SH2 domain and SOCS box) with TRIM8.
Interacts with CUL2.
Interacts with AXL and FGFR3 (By similarity).
Interacts with INSR.
Interacts with TRIM8 (By similarity).
Interacts with DCUN1D1 (By similarity).
By similarity4 PublicationsGO - Molecular functioni
- insulin-like growth factor receptor binding Source: MGI
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198719, 32 interactors |
IntActi | O35716, 6 interactors |
MINTi | O35716 |
STRINGi | 10090.ENSMUSP00000038121 |
Miscellaneous databases
RNActi | O35716, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 80 – 175 | SH2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 162 – 211 | SOCS boxPROSITE-ProRule annotationAdd BLAST | 50 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 56 – 67 | Kinase inhibitory region (KIR)Add BLAST | 12 | |
Regioni | 68 – 79 | Extended SH2 subdomain (ESS)Add BLAST | 12 | |
Regioni | 174 – 183 | Interaction with Elongin BC complex | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 26 – 33 | Poly-Ser | 8 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000161164 |
HOGENOMi | CLU_079452_2_1_1 |
InParanoidi | O35716 |
OMAi | ETFDCLF |
OrthoDBi | 1135696at2759 |
PhylomeDBi | O35716 |
TreeFami | TF321368 |
Family and domain databases
CDDi | cd10382, SH2_SOCS1, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028411, SOCS1 IPR035861, SOCS1_SH2 IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF4, PTHR10155:SF4, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MVARNQVAAD NAISPAAEPR RRSEPSSSSS SSSPAAPVRP RPCPAVPAPA
60 70 80 90 100
PGDTHFRTFR SHSDYRRITR TSALLDACGF YWGPLSVHGA HERLRAEPVG
110 120 130 140 150
TFLVRDSRQR NCFFALSVKM ASGPTSIRVH FQAGRFHLDG SRETFDCLFE
160 170 180 190 200
LLEHYVAAPR RMLGAPLRQR RVRPLQELCR QRIVAAVGRE NLARIPLNPV
210
LRDYLSSFPF QI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 141 | S → N in BAA21538 (PubMed:9202126).Curated | 1 | |
Sequence conflicti | 141 | S → N in BAA21539 (PubMed:9202127).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88325 mRNA Translation: AAB62400.1 AB000677 mRNA Translation: BAA21538.1 AB000710 mRNA Translation: BAA21539.1 AF120490 mRNA Translation: AAD24777.1 AF180302 mRNA Translation: AAD53324.1 AK028632 mRNA Translation: BAC26040.1 AK154706 mRNA Translation: BAE32775.1 BC132366 mRNA Translation: AAI32367.1 BC132368 mRNA Translation: AAI32369.1 |
CCDSi | CCDS27952.1 |
RefSeqi | NP_001258532.1, NM_001271603.1 NP_034026.1, NM_009896.2 |
Genome annotation databases
Ensembli | ENSMUST00000038099; ENSMUSP00000038121; ENSMUSG00000038037 ENSMUST00000229866; ENSMUSP00000155530; ENSMUSG00000038037 |
GeneIDi | 12703 |
KEGGi | mmu:12703 |
UCSCi | uc007yed.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88325 mRNA Translation: AAB62400.1 AB000677 mRNA Translation: BAA21538.1 AB000710 mRNA Translation: BAA21539.1 AF120490 mRNA Translation: AAD24777.1 AF180302 mRNA Translation: AAD53324.1 AK028632 mRNA Translation: BAC26040.1 AK154706 mRNA Translation: BAE32775.1 BC132366 mRNA Translation: AAI32367.1 BC132368 mRNA Translation: AAI32369.1 |
CCDSi | CCDS27952.1 |
RefSeqi | NP_001258532.1, NM_001271603.1 NP_034026.1, NM_009896.2 |
3D structure databases
SMRi | O35716 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198719, 32 interactors |
IntActi | O35716, 6 interactors |
MINTi | O35716 |
STRINGi | 10090.ENSMUSP00000038121 |
PTM databases
iPTMneti | O35716 |
PhosphoSitePlusi | O35716 |
Proteomic databases
EPDi | O35716 |
PaxDbi | O35716 |
PRIDEi | O35716 |
ProteomicsDBi | 257284 |
Protocols and materials databases
Antibodypediai | 4157, 630 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000038099; ENSMUSP00000038121; ENSMUSG00000038037 ENSMUST00000229866; ENSMUSP00000155530; ENSMUSG00000038037 |
GeneIDi | 12703 |
KEGGi | mmu:12703 |
UCSCi | uc007yed.1, mouse |
Organism-specific databases
CTDi | 8651 |
MGIi | MGI:1354910, Socs1 |
Phylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000161164 |
HOGENOMi | CLU_079452_2_1_1 |
InParanoidi | O35716 |
OMAi | ETFDCLF |
OrthoDBi | 1135696at2759 |
PhylomeDBi | O35716 |
TreeFami | TF321368 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling R-MMU-877300, Interferon gamma signaling R-MMU-877312, Regulation of IFNG signaling R-MMU-909733, Interferon alpha/beta signaling R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SABIO-RKi | O35716 |
Miscellaneous databases
BioGRID-ORCSi | 12703, 16 hits in 55 CRISPR screens |
ChiTaRSi | Socs1, mouse |
PROi | PR:O35716 |
RNActi | O35716, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038037, Expressed in thymus and 65 other tissues |
Genevisiblei | O35716, MM |
Family and domain databases
CDDi | cd10382, SH2_SOCS1, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028411, SOCS1 IPR035861, SOCS1_SH2 IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF4, PTHR10155:SF4, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOCS1_MOUSE | |
Accessioni | O35716Primary (citable) accession number: O35716 Secondary accession number(s): A2RT46, O35960, Q3U3L0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | January 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families