Socs1

Functionⁱ

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).By similarity3 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

1-phosphatidylinositol-3-kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor receptor binding Source: MGI
kinase inhibitor activity
Source: MGI
Inferred from direct assayⁱ
- 9202126
- 9889194
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to amino acid stimulus
Source: MGI
Inferred from direct assayⁱ
- 20548288
cellular response to cytokine stimulus
Source: MGI
Inferred from sequence orthologyⁱ
- 19414010
cellular response to organic cyclic compound
Source: MGI
Inferred from sequence orthologyⁱ
- 19414010
cytokine-mediated signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 9202126
- 9202127
fat cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16127460
JAK-STAT cascade
Source: MGI
Inferred from direct assayⁱ
- 11854514
negative regulation of CD8-positive, alpha-beta T cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24880459
negative regulation of insulin receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 15169905
negative regulation of JAK-STAT cascade
Source: MGI
Inferred from mutant phenotypeⁱ
- 11371356
negative regulation of tyrosine phosphorylation of STAT protein
Source: MGI
Inferred from direct assayⁱ
- 9202127
phosphatidylinositol phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of CD4-positive, alpha-beta T cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24880459
positive regulation of regulatory T cell differentiation Source: MGI
protein ubiquitination Source: UniProtKB-UniPathway
regulation of activation of Janus kinase activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 21606371
regulation of cytokine secretion
Source: MGI
Inferred from mutant phenotypeⁱ
- 21606371
regulation of growth Source: UniProtKB-KW
regulation of interferon-gamma-mediated signaling pathway Source: InterPro
regulation of JAK-STAT cascade
Source: MGI
Inferred from mutant phenotypeⁱ
- 21606371
regulation of protein phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 15169905
regulation of tyrosine phosphorylation of STAT protein
Source: MGI
Inferred from mutant phenotypeⁱ
- 21606371

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor
Biological process	Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling R-MMU-877300 Interferon gamma signaling R-MMU-877312 Regulation of IFNG signaling R-MMU-909733 Interferon alpha/beta signaling R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
SABIO-RKⁱ	O35716
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Suppressor of cytokine signaling 1 Short name: SOCS-1 Alternative name(s): JAK-binding protein Short name: JAB STAT-induced STAT inhibitor 1 Short name: SSI-1
Gene namesⁱ	Name:Socs1 Synonyms:Cish1, Ssi1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 16

Organism-specific databases

MGIⁱ	MGI:1354910 Socs1

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice exhibit lymphocyte deficiency and degeneration of the liver parenchyma. Animals die within 3 weeks of age. Mutants show a much higher frequency of CD8 single positive thymocytes (PubMed:24880459).2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	51	P → A: No effect on LIF signal transduction suppression.	1
Mutagenesisⁱ	52	G → A: No effect on LIF signal transduction suppression.	1
Mutagenesisⁱ	53	D → A or R: No effect on LIF signal transduction suppression.	1
Mutagenesisⁱ	54	T → A: No effect on LIF signal transduction suppression.	1
Mutagenesisⁱ	55	H → A or D: No effect on JAK signal transduction suppression. 1 Publication	1
Mutagenesisⁱ	56	F → A, S or D: Loss of JAK signal transduction suppression. 1 Publication	1
Mutagenesisⁱ	56	F → E or S: Reduced binding to JH1. 1 Publication	1
Mutagenesisⁱ	56	F → L: No effect on JAK signal transduction inhibition nor on binding to JH1. 1 Publication	1
Mutagenesisⁱ	57	R → A or E: No effect on JAK signal transduction suppression. 1 Publication	1
Mutagenesisⁱ	58	T → A: No effect on JAK signal transduction suppression. 1 Publication	1
Mutagenesisⁱ	59	F → A or E: Loss of JAK signal transduction suppression. Reduced binding to JH1. 2 Publications	1
Mutagenesisⁱ	59	F → D: Loss of JAK signal transduction suppression. Destabilization of SOCS1. 2 Publications	1
Mutagenesisⁱ	59	F → L: No effect on JAK signal transduction suppression nor on binding to JH1. 2 Publications	1
Mutagenesisⁱ	60	R → A: No effect on LIF signal transduction suppression. 1 Publication	1
Mutagenesisⁱ	61	S → E: No effect on JAK signal transduction suppression. 1 Publication	1
Mutagenesisⁱ	62	H → E: No effect on JAK signal transduction suppression. 1 Publication	1
Mutagenesisⁱ	64	D → R: Loss of JAK signal transduction suppression. Reduced binding to JH1. 1 Publication	1
Mutagenesisⁱ	65	Y → A: Some loss of JAK signal transduction signaling. Reduced binding to JH1. 1 Publication	1
Mutagenesisⁱ	68	I → E: Loss of binding to JH1/Y-1007 of JAK2 and loss of signal transduction suppression.	1
Mutagenesisⁱ	70	R → E: No effect on LIF signal transduction suppression.	1
Mutagenesisⁱ	75	L → E: Loss of binding to JH1/Y-1007 of JAK2 and loss of signal transduction suppression.	1
Mutagenesisⁱ	105	R → K: Loss of LIF signal transduction suppression. Loss of binding to KIT. No effect on binding to VAV. 1 Publication	1
Mutagenesisⁱ	105	R → Q: Loss of IL-6 signal transduction suppression. No effect on binding to TYK2. 1 Publication	1
Mutagenesisⁱ	175	L → P: Abolishes interaction with elongin BC complex; when associated with F-179. 1 Publication	1
Mutagenesisⁱ	179	C → F: Abolishes interaction with elongin BC complex; when associated with P-175. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181236	1 – 212	Suppressor of cytokine signaling 1Add BLAST		212

Proteomic databases

EPDⁱ	O35716
PaxDbⁱ	O35716
PRIDEⁱ	O35716

PTM databases

iPTMnetⁱ	O35716
PhosphoSitePlusⁱ	O35716

Expressionⁱ

Tissue specificityⁱ

High expression in thymus. Lower expression in lung and spleen. Expressed in both Th1 and Th2 cells.1 Publication

Developmental stageⁱ

In the developing brain, expressed at low levels from E10 stages to young adulthood (P25) with peak levels from E14 to P8. In the cortex, expression first observed at E14 uniformly in all cells. Also expressed in the innermost layers of the developing retina. Levels of expression remain unchanged from P8 until adulthood. In the peripheral nervous system, high levels found in virtually all neurons of the dorsal root ganglion.

Inductionⁱ

By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.

Gene expression databases

Bgeeⁱ	ENSMUSG00000038037 Expressed in 27 organ(s), highest expression level in thymus
CleanExⁱ	MM_SOCS1
Genevisibleⁱ	O35716 MM

Interactionⁱ

Subunit structureⁱ

Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domain to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (ELOB and ELOC). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with CUL2. Interacts with AXL and FGFR3 (By similarity). Interacts with INSR. Interacts with TRIM8 (By similarity).By similarity4 Publications

GO - Molecular functionⁱ

insulin-like growth factor receptor binding Source: MGI
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198719, 31 interactors
IntActⁱ	O35716, 6 interactors
Molecular INTeraction database More...MINTⁱ	O35716
STRINGⁱ	10090.ENSMUSP00000038121

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O35716
SMRⁱ	O35716
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	80 – 175	SH2PROSITE-ProRule annotationAdd BLAST		96
Domainⁱ	162 – 211	SOCS boxPROSITE-ProRule annotationAdd BLAST		50

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	56 – 67	Kinase inhibitory region (KIR)Add BLAST	12
Regionⁱ	68 – 79	Extended SH2 subdomain (ESS)Add BLAST	12
Regionⁱ	174 – 183	Interaction with Elongin BC complex	10

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	26 – 33	Poly-Ser		8

Domainⁱ

The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x₃-C-x₃-[AILV] and is part of the SOCS box.

Sequence similaritiesⁱ

Belongs to the SOCS1 family.Curated

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	KOG4566 Eukaryota ENOG4111V4J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119136
HOGENOMⁱ	HOG000236320
HOVERGENⁱ	HBG002457
InParanoidⁱ	O35716
KEGG Orthology (KO) More...KOⁱ	K04694
OMAⁱ	CGFYWGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TJW
PhylomeDBⁱ	O35716
TreeFamⁱ	TF321368

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10382 SH2_SOCS1, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028411 SOCS1 IPR035861 SOCS1_SH2 IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf
PANTHERⁱ	PTHR44621 PTHR44621, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF07525 SOCS_box, 1 hit
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O35716-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVARNQVAAD NAISPAAEPR RRSEPSSSSS SSSPAAPVRP RPCPAVPAPA 
        60         70         80         90        100
PGDTHFRTFR SHSDYRRITR TSALLDACGF YWGPLSVHGA HERLRAEPVG 
       110        120        130        140        150
TFLVRDSRQR NCFFALSVKM ASGPTSIRVH FQAGRFHLDG SRETFDCLFE 
       160        170        180        190        200
LLEHYVAAPR RMLGAPLRQR RVRPLQELCR QRIVAAVGRE NLARIPLNPV 
       210 
LRDYLSSFPF QI

Length:212

Mass (Da):23,715

Last modified:January 1, 1998 - v1

Checksum:ⁱ4621E05DC3D44C69

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	141	S → N in BAA21538 (PubMed:9202126).Curated		1
Sequence conflictⁱ	141	S → N in BAA21539 (PubMed:9202127).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U88325 mRNA Translation: AAB62400.1 AB000677 mRNA Translation: BAA21538.1 AB000710 mRNA Translation: BAA21539.1 AF120490 mRNA Translation: AAD24777.1 AF180302 mRNA Translation: AAD53324.1 AK028632 mRNA Translation: BAC26040.1 AK154706 mRNA Translation: BAE32775.1 BC132366 mRNA Translation: AAI32367.1 BC132368 mRNA Translation: AAI32369.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27952.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001258532.1, NM_001271603.1 NP_034026.1, NM_009896.2
UniGeneⁱ	Mm.130

Genome annotation databases

Ensemblⁱ	ENSMUST00000038099; ENSMUSP00000038121; ENSMUSG00000038037 ENSMUST00000229866; ENSMUSP00000155530; ENSMUSG00000038037
GeneIDⁱ	12703
KEGGⁱ	mmu:12703
UCSC genome browser More...UCSCⁱ	uc007yed.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35716	Suppressor of cytokine signaling 1		CRIGR		93	UniRef100_O35716

Protein	Similar proteins		Species	Score	Length	Source
O35716	Suppressor of cytokine signaling 1		HUMAN		211	UniRef90_O35716
Suppressor of cytokine signaling 1		CRIGR		93
Suppressor of cytokine signaling 1		PTEAL		215
SOCS1 isoform 1		PONAB		213
Uncharacterized protein		CERAT		213
+29

Protein	Similar proteins		Species	Score	Length	Source
O35716	Suppressor of cytokine signaling 1		HUMAN		211	UniRef50_O35716
Suppressor of cytokine signaling 1		RAT		212
Suppressor of cytokine signaling 1		CRIGR		93
Suppressor of cytokine signaling 1		PTEAL		215
Uncharacterized protein		CERAT		213
+183

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U88325 mRNA Translation: AAB62400.1 AB000677 mRNA Translation: BAA21538.1 AB000710 mRNA Translation: BAA21539.1 AF120490 mRNA Translation: AAD24777.1 AF180302 mRNA Translation: AAD53324.1 AK028632 mRNA Translation: BAC26040.1 AK154706 mRNA Translation: BAE32775.1 BC132366 mRNA Translation: AAI32367.1 BC132368 mRNA Translation: AAI32369.1
CCDSⁱ	CCDS27952.1
RefSeqⁱ	NP_001258532.1, NM_001271603.1 NP_034026.1, NM_009896.2
UniGeneⁱ	Mm.130

3D structure databases

ProteinModelPortalⁱ	O35716
SMRⁱ	O35716
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198719, 31 interactors
IntActⁱ	O35716, 6 interactors
MINTⁱ	O35716
STRINGⁱ	10090.ENSMUSP00000038121

PTM databases

iPTMnetⁱ	O35716
PhosphoSitePlusⁱ	O35716

Proteomic databases

EPDⁱ	O35716
PaxDbⁱ	O35716
PRIDEⁱ	O35716

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000038099; ENSMUSP00000038121; ENSMUSG00000038037 ENSMUST00000229866; ENSMUSP00000155530; ENSMUSG00000038037
GeneIDⁱ	12703
KEGGⁱ	mmu:12703
UCSCⁱ	uc007yed.1 mouse

Organism-specific databases

CTDⁱ	8651
MGIⁱ	MGI:1354910 Socs1

Phylogenomic databases

eggNOGⁱ	KOG4566 Eukaryota ENOG4111V4J LUCA
GeneTreeⁱ	ENSGT00760000119136
HOGENOMⁱ	HOG000236320
HOVERGENⁱ	HBG002457
InParanoidⁱ	O35716
KOⁱ	K04694
OMAⁱ	CGFYWGP
OrthoDBⁱ	EOG091G0TJW
PhylomeDBⁱ	O35716
TreeFamⁱ	TF321368

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling R-MMU-877300 Interferon gamma signaling R-MMU-877312 Regulation of IFNG signaling R-MMU-909733 Interferon alpha/beta signaling R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
SABIO-RKⁱ	O35716

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O35716
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038037 Expressed in 27 organ(s), highest expression level in thymus
CleanExⁱ	MM_SOCS1
Genevisibleⁱ	O35716 MM

Family and domain databases

CDDⁱ	cd10382 SH2_SOCS1, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028411 SOCS1 IPR035861 SOCS1_SH2 IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf
PANTHERⁱ	PTHR44621 PTHR44621, 1 hit
Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF07525 SOCS_box, 1 hit
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOCS1_MOUSE
Accessionⁱ	O35716Primary (citable) accession number: O35716 Secondary accession number(s): A2RT46, O35960, Q3U3L0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O35716 (SOCS1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Suppressor of cytokine signaling 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ