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Protein

Liprin-beta-2

Gene

Ppfibp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity).By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-beta-2
Alternative name(s):
Coiled-coil-like protein 1
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2
Short name:
PTPRF-interacting protein-binding protein 2
Gene namesi
Name:Ppfibp2
Synonyms:Cclp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:894649 Ppfibp2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910371 – 882Liprin-beta-2Add BLAST882

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei328PhosphoserineBy similarity1
Modified residuei362PhosphoserineBy similarity1
Modified residuei386PhosphoserineCombined sources1
Modified residuei502PhosphoserineCombined sources1
Modified residuei518PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35711
PaxDbiO35711
PeptideAtlasiO35711
PRIDEiO35711

PTM databases

iPTMnetiO35711
PhosphoSitePlusiO35711

Expressioni

Tissue specificityi

Expressed widely. Strong expression in liver, kidney, intestine, heart, lung and testis. Low expression in brain and thymus.1 Publication

Developmental stagei

Found at 10.5 dpc through 16.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000036528
ExpressionAtlasiO35711 baseline and differential

Interactioni

Subunit structurei

Forms homodimers and heterodimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35711, 1 interactor
MINTiO35711
STRINGi10090.ENSMUSP00000095738

Structurei

3D structure databases

ProteinModelPortaliO35711
SMRiO35711
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini564 – 628SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini636 – 699SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini724 – 789SAM 3PROSITE-ProRule annotationAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili101 – 303By similarityAdd BLAST203

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha (By similarity).By similarity

Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1899 Eukaryota
ENOG410XSFF LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000082535
HOVERGENiHBG052331
InParanoidiO35711
OMAiHIPRQDS
OrthoDBiEOG091G01OJ
PhylomeDBiO35711
TreeFamiTF314207

Family and domain databases

CDDicd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030435 PPFIBP2
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF18 PTHR12587:SF18, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O35711-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSDASHMLE AALEQMDGII AGTKTAADFS DGTCEPGLSP PSTCLNSMPV
60 70 80 90 100
LHLIEDLRLA LEMLALPQER EALLSQVPGP TATYIKEWFE DSLSQVNHHG
110 120 130 140 150
AASNETYQER LARLEGDKES LILQVSVLTD QVEAQGEKIR DLEVCLEGHQ
160 170 180 190 200
VKLNAAEEML QQELLSRTSL ETQKLDLMTE VSELKLKLVG MEKEQKEQEE
210 220 230 240 250
KQRKAEELLQ ELKHLKIKVE ELENERNQYE WELKATKAEV AQLQEQVALK
260 270 280 290 300
DAEIERLHSQ LSRSAALHSD HAERDQEIHR LKMGMETLLV ANEDKDRRIE
310 320 330 340 350
ELTGLLNKYL RVKEIVMATQ GPSERTLSIN EDEIEGSFRK WNTTNKSPEE
360 370 380 390 400
VPKQEISPRC SSPTPGPPPL PQKSLESRAQ KKLSCSLEDL RRESGDKCVD
410 420 430 440 450
GNQLSPVGEP KDSSFLAEQK YPTLPGKLSG ATPNGEAAKS PPTASLQPDS
460 470 480 490 500
SGSSQPKLNR GWSVSAPVLR DTEGGWEDIV SSASSGTESS PQSPVTPDGK
510 520 530 540 550
RSPKGIKKFW GKIRRTQSGN FNTDAPGMAE FRRGGLRATA GPRLSRTRDT
560 570 580 590 600
KGQKCDANAP FAQWSTERVC TWMEDFGLGQ YVIFARQWVT SGHTLLTATP
610 620 630 640 650
QDMEKELGIK HPLHRKKLVL AVKAINAKQE ETSALLDHIW VTRWLDDIGL
660 670 680 690 700
PQYKDQFHES RVDGRMLQYL TVNDLLFLKV TSQLHHLSIK CAIHVLHVNK
710 720 730 740 750
FNPNCLHRRP ADESNLSPSE VVQWSNHRVM EWLRSVDLAE YAPNLRGSGV
760 770 780 790 800
HGGLIILEPR FTGDTLAMLL NIPPQKTLLR RHLTTKFNAL IGPEAEQEKR
810 820 830 840 850
DKMASPAYTP LTTTAKVRPR KLGFSHFGNM RKKKFDESTD YICPMEPGDA
860 870 880
VSDSHRVYGV YRGLSPLDNH ELDGLDQVGQ IS
Length:882
Mass (Da):98,753
Last modified:June 12, 2007 - v3
Checksum:i4CD5BDF5C2F1A146
GO
Isoform 2 (identifier: O35711-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-469: Missing.

Note: No experimental confirmation available.
Show »
Length:871
Mass (Da):97,585
Checksum:i3BA0F9366EAF8680
GO
Isoform 3 (identifier: O35711-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-200: VLTDQVEAQG...MEKEQKEQEE → SLLPQLPQER...AKGDEYILCH
     201-882: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:200
Mass (Da):21,742
Checksum:i50F4AB6DE4C3800B
GO
Isoform 4 (identifier: O35711-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-469: Missing.
     877-882: QVGQIS → QMAPSEGTVTQIGLLSQDIHRLTTLLSQDQLLNDPPGCP

Note: No experimental confirmation available.
Show »
Length:904
Mass (Da):101,143
Checksum:i8567E70A422C1449
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4D → G in AAB61902 (PubMed:9199242).Curated1
Sequence conflicti470R → G in AAB61902 (PubMed:9199242).Curated1
Sequence conflicti699Missing in AAH03966 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009401127 – 200VLTDQ…KEQEE → SLLPQLPQERDAQCESSVGK RWEPIYLSCAAEHLPLHTSS PVGRLKLGASNEQNGPRHPG ACKSAKGDEYILCH in isoform 3. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_009402201 – 882Missing in isoform 3. 1 PublicationAdd BLAST682
Alternative sequenceiVSP_009403459 – 469Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_026136877 – 882QVGQIS → QMAPSEGTVTQIGLLSQDIH RLTTLLSQDQLLNDPPGCP in isoform 4. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79024 mRNA Translation: AAB61902.1
AK035364 mRNA Translation: BAC29047.1
BC003966 mRNA Translation: AAH03966.1
BC055935 mRNA Translation: AAH55935.1
BC100346 mRNA Translation: AAI00347.1
CCDSiCCDS21691.1 [O35711-1]
CCDS52356.1 [O35711-4]
RefSeqiNP_001157029.1, NM_001163557.1 [O35711-4]
NP_032931.2, NM_008905.2
UniGeneiMm.2817

Genome annotation databases

EnsembliENSMUST00000098134; ENSMUSP00000095738; ENSMUSG00000036528 [O35711-4]
GeneIDi19024
KEGGimmu:19024
UCSCiuc009jbd.2 mouse [O35711-3]
uc009jbf.1 mouse [O35711-4]
uc009jbh.2 mouse [O35711-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLIPB2_MOUSE
AccessioniPrimary (citable) accession number: O35711
Secondary accession number(s): Q497W6
, Q7TMG4, Q8CBS6, Q99KX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 12, 2007
Last modified: February 28, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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