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Protein

Ectoderm-neural cortex protein 1

Gene

Enc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Ectoderm-neural cortex protein 1
Short name:
ENC-1
Gene namesi
Name:Enc1
Synonyms:Enc-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:109610 Enc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190691 – 589Ectoderm-neural cortex protein 1Add BLAST589

Post-translational modificationi

Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiO35709
PaxDbiO35709
PeptideAtlasiO35709
PRIDEiO35709

PTM databases

iPTMnetiO35709
PhosphoSitePlusiO35709

Expressioni

Tissue specificityi

Primarily expressed in the nervous system.

Developmental stagei

Expression is highly dynamic but mostly restricted to the nervous system. Outside the nervous system, expression is detected in the rostral-most somitomere of the presomitic mesoderm, at the times corresponding to the epithelialization that precedes somite formation. First detected in the brain and spinal chord of 12 PC embryos.

Gene expression databases

BgeeiENSMUSG00000041773 Expressed in 315 organ(s), highest expression level in striatum
CleanExiMM_ENC1
GenevisibleiO35709 MM

Interactioni

Subunit structurei

Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells. Part of a complex that contains CUL3, RBX1 and ENC1 (By similarity). Interacts indirectly with KEAP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199448, 1 interactor
STRINGi10090.ENSMUSP00000038783

Structurei

3D structure databases

ProteinModelPortaliO35709
SMRiO35709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 114BTBPROSITE-ProRule annotationAdd BLAST69
Repeati296 – 340Kelch 1Add BLAST45
Repeati341 – 388Kelch 2Add BLAST48
Repeati389 – 444Kelch 3Add BLAST56
Repeati446 – 492Kelch 4Add BLAST47
Repeati494 – 538Kelch 5Add BLAST45
Repeati539 – 585Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00930000150826
HOGENOMiHOG000232171
HOVERGENiHBG000905
InParanoidiO35709
KOiK10462
OMAiMNIYLFH
OrthoDBiEOG091G03JU
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR030562 ENC1
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24410:SF5 PTHR24410:SF5, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 4 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

O35709-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL
60 70 80 90 100
HAGNRTFPCH RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL
110 120 130 140 150
LLDYAYSSRV IINEENAESL LEAGDMLEFQ DIRDACAEFL EKNLHPTNCL
160 170 180 190 200
GMLLLSDAHQ CTKLYELSWR MCLSNFQTIR KNEDFLQLPQ DMVVQLLSSE
210 220 230 240 250
ELETEDERLV YESAMNWISY DLKKRYCYLP ELLQTVRLAL LPAIYLMENV
260 270 280 290 300
AMEELITKQR KSKEIVEEAI RCKLKILQND GVVTSLCARP RKTGHALFLL
310 320 330 340 350
GGQTFMCDKL YLVDQKAKEI IPKADIPSPR KEFSACAIGC KVYITGGRGS
360 370 380 390 400
ENGVSKDVWV YDTLHEEWSK AAPMLVARFG HGSAELKHCL YVVGGHTAAT
410 420 430 440 450
GCLPASPSVS LKQVEQYDPT TNKWTMVAPL REGVSNAAVV SAKLKLFAFG
460 470 480 490 500
GTSVSHDKLP KVQCYDQCEN RWSVPATCPQ PWRYTAAAVL GNQIFIMGGD
510 520 530 540 550
TEFSACSAYK FNSETYQWTK VGDVTAKRMS CHAVASGNKL YVVGGYFGIQ
560 570 580
RCKTLDCYDP TLDVWNSITT VPYSLIPTAF VSTWKHLPS
Length:589
Mass (Da):66,113
Last modified:July 27, 2011 - v2
Checksum:i21EA2CA07EE66B86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182N → S in AAB64206 (PubMed:9096139).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65079 mRNA Translation: AAB64206.1
AK049187 mRNA Translation: BAC33597.1
AK132173 mRNA Translation: BAE21011.1
CH466567 Genomic DNA Translation: EDL00871.1
BC049186 mRNA Translation: AAH49186.1
BC058098 mRNA Translation: AAH58098.1
CCDSiCCDS26710.1
RefSeqiNP_031956.3, NM_007930.4
UniGeneiMm.241073

Genome annotation databases

EnsembliENSMUST00000041623; ENSMUSP00000038783; ENSMUSG00000041773
GeneIDi13803
KEGGimmu:13803
UCSCiuc007rod.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65079 mRNA Translation: AAB64206.1
AK049187 mRNA Translation: BAC33597.1
AK132173 mRNA Translation: BAE21011.1
CH466567 Genomic DNA Translation: EDL00871.1
BC049186 mRNA Translation: AAH49186.1
BC058098 mRNA Translation: AAH58098.1
CCDSiCCDS26710.1
RefSeqiNP_031956.3, NM_007930.4
UniGeneiMm.241073

3D structure databases

ProteinModelPortaliO35709
SMRiO35709
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199448, 1 interactor
STRINGi10090.ENSMUSP00000038783

PTM databases

iPTMnetiO35709
PhosphoSitePlusiO35709

Proteomic databases

MaxQBiO35709
PaxDbiO35709
PeptideAtlasiO35709
PRIDEiO35709

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041623; ENSMUSP00000038783; ENSMUSG00000041773
GeneIDi13803
KEGGimmu:13803
UCSCiuc007rod.2 mouse

Organism-specific databases

CTDi8507
MGIiMGI:109610 Enc1

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00930000150826
HOGENOMiHOG000232171
HOVERGENiHBG000905
InParanoidiO35709
KOiK10462
OMAiMNIYLFH
OrthoDBiEOG091G03JU
TreeFamiTF329218

Miscellaneous databases

ChiTaRSiEnc1 mouse
PROiPR:O35709
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041773 Expressed in 315 organ(s), highest expression level in striatum
CleanExiMM_ENC1
GenevisibleiO35709 MM

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR030562 ENC1
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24410:SF5 PTHR24410:SF5, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 4 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENC1_MOUSE
AccessioniPrimary (citable) accession number: O35709
Secondary accession number(s): Q8C7V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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