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Protein

Matrilin-3

Gene

Matn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cartilage development Source: MGI
  • growth plate cartilage chondrocyte morphogenesis Source: GO_Central

Enzyme and pathway databases

ReactomeiR-MMU-3000178 ECM proteoglycans
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrilin-3
Gene namesi
Name:Matn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1328350 Matn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000765828 – 481Matrilin-3Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193Omega-N-methylarginineCombined sources1
Disulfide bondi263 ↔ 274PROSITE-ProRule annotation
Disulfide bondi270 ↔ 284PROSITE-ProRule annotation
Disulfide bondi286 ↔ 299PROSITE-ProRule annotation
Disulfide bondi305 ↔ 316PROSITE-ProRule annotation
Disulfide bondi312 ↔ 326PROSITE-ProRule annotation
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi328 ↔ 341PROSITE-ProRule annotation
Disulfide bondi347 ↔ 358PROSITE-ProRule annotation
Disulfide bondi354 ↔ 368PROSITE-ProRule annotation
Disulfide bondi370 ↔ 383PROSITE-ProRule annotation
Disulfide bondi389 ↔ 400PROSITE-ProRule annotation
Disulfide bondi396 ↔ 410PROSITE-ProRule annotation
Disulfide bondi412 ↔ 425PROSITE-ProRule annotation
Modified residuei436Phosphoserine; by FAM20CBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

MaxQBiO35701
PaxDbiO35701
PRIDEiO35701

PTM databases

iPTMnetiO35701
PhosphoSitePlusiO35701

Expressioni

Tissue specificityi

Strongly expressed in growing skeletal tissue such as epiphyseal growth plate or in bone undergoing growth and remodeling. In the bone, actively synthesized in osteoblasts and osteocytes. Expressed in cartilage of sternum, femur, vertebrae, trachea, articular and epiphyseal cartilage, cartilage of developing bones and bones.

Developmental stagei

The earliest expression could be detected in a 12.5 dpc embryo in the cartilage anlage of the developing bones. At 14.5 dpc the primordial skeleton shows a strong expression. At birth present in the developing occipital bones, bones of the nasal cavity, manubrium and corpus of sternum as well as in the cartilage plates of trachea. At no stage of development detected in extraskeletal tissues.

Gene expression databases

BgeeiENSMUSG00000020583 Expressed in 96 organ(s), highest expression level in humerus cartilage element
CleanExiMM_MATN3
GenevisibleiO35701 MM

Interactioni

Subunit structurei

Can form homooligomers (monomers, dimers, trimers and tetramers) and heterooligomers with matrilin-1. Interacts with COMP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020899

Structurei

3D structure databases

ProteinModelPortaliO35701
SMRiO35701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 253VWFAPROSITE-ProRule annotationAdd BLAST176
Domaini259 – 300EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini301 – 342EGF-like 2PROSITE-ProRule annotationAdd BLAST42
Domaini343 – 384EGF-like 3PROSITE-ProRule annotationAdd BLAST42
Domaini385 – 426EGF-like 4PROSITE-ProRule annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili451 – 475Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG4111IJ5 LUCA
GeneTreeiENSGT00930000150889
HOGENOMiHOG000263415
HOVERGENiHBG056906
InParanoidiO35701
KOiK19467
OMAiICVNDGA
OrthoDBiEOG091G04O4
TreeFamiTF330078

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR030765 Matrilin_3
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR45117 PTHR45117, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF57184 SSF57184, 1 hit
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 4 hits
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35701-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLSAPLRHL PGLLLLLWPL LLLPSLAAPG RLARASVRRL GTRVPGGSPG
60 70 80 90 100
HLSALATSTR APYSGGRGAG VCKSRPLDLV FIIDSSRSVR PLEFTKVKTF
110 120 130 140 150
VSRIIDTLDI GATDTRVAVV NYASTVKIEF QLNTYSDKQA LKQAVARITP
160 170 180 190 200
LSTGTMSGLA IQTAMEEAFT VEAGARGPMS NIPKVAIIVT DGRPQDQVNE
210 220 230 240 250
VAARARASGI ELYAVGVDRA DMESLKMMAS KPLEEHVFYV ETYGVIEKLS
260 270 280 290 300
ARFQETFCAL DQCMLGTHQC QHVCVSDGDG KHHCECSQGY TLNADGKTCS
310 320 330 340 350
AIDKCALSTH GCEQICVNDR NGSYHCECYG GYALNADRRT CAALDKCASG
360 370 380 390 400
THGCQHICVN DGAGSHHCEC FEGYTLNADK KTCSVRNKCA LGTHGCQHIC
410 420 430 440 450
VSDGAVAYHC DCFPGYTLND DKKTCSDIEE ARSLISIEDA CGCGATLAFQ
460 470 480
EKVSSHLQKL NTKLDNILKK LKVTEYGQVH R
Length:481
Mass (Da):51,845
Last modified:July 27, 2011 - v2
Checksum:iBC82B8A140344CBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317V → I in CAA71532 (PubMed:9287130).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10521 mRNA Translation: CAA71532.1
AJ242929
, AJ242930, AJ242931, AJ242932, AJ242933, AJ242934, AJ242935, AJ242936 Genomic DNA Translation: CAB72265.1
AK048456 mRNA Translation: BAC33343.1
CCDSiCCDS25806.1
RefSeqiNP_034900.4, NM_010770.4
UniGeneiMm.42226

Genome annotation databases

EnsembliENSMUST00000020899; ENSMUSP00000020899; ENSMUSG00000020583
GeneIDi17182
KEGGimmu:17182
UCSCiuc007nag.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10521 mRNA Translation: CAA71532.1
AJ242929
, AJ242930, AJ242931, AJ242932, AJ242933, AJ242934, AJ242935, AJ242936 Genomic DNA Translation: CAB72265.1
AK048456 mRNA Translation: BAC33343.1
CCDSiCCDS25806.1
RefSeqiNP_034900.4, NM_010770.4
UniGeneiMm.42226

3D structure databases

ProteinModelPortaliO35701
SMRiO35701
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020899

PTM databases

iPTMnetiO35701
PhosphoSitePlusiO35701

Proteomic databases

MaxQBiO35701
PaxDbiO35701
PRIDEiO35701

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020899; ENSMUSP00000020899; ENSMUSG00000020583
GeneIDi17182
KEGGimmu:17182
UCSCiuc007nag.2 mouse

Organism-specific databases

CTDi4148
MGIiMGI:1328350 Matn3

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG4111IJ5 LUCA
GeneTreeiENSGT00930000150889
HOGENOMiHOG000263415
HOVERGENiHBG056906
InParanoidiO35701
KOiK19467
OMAiICVNDGA
OrthoDBiEOG091G04O4
TreeFamiTF330078

Enzyme and pathway databases

ReactomeiR-MMU-3000178 ECM proteoglycans
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:O35701
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020583 Expressed in 96 organ(s), highest expression level in humerus cartilage element
CleanExiMM_MATN3
GenevisibleiO35701 MM

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR030765 Matrilin_3
IPR036337 Matrilin_cc_sf
IPR019466 Matrilin_coiled-coil_trimer
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR45117 PTHR45117, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF10393 Matrilin_ccoil, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM01279 Matrilin_ccoil, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF57184 SSF57184, 1 hit
SSF58002 SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 4 hits
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMATN3_MOUSE
AccessioniPrimary (citable) accession number: O35701
Secondary accession number(s): Q543Q2, Q9JHM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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