Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Gene

Ndufa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Alternative name(s):
Complex I-MWFE
Short name:
CI-MWFE
NADH-ubiquinone oxidoreductase MWFE subunit
Gene namesi
Name:Ndufa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1929511 Ndufa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188181 – 70NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1Add BLAST70

Proteomic databases

EPDiO35683
PaxDbiO35683
PeptideAtlasiO35683
PRIDEiO35683

PTM databases

iPTMnetiO35683
PhosphoSitePlusiO35683

Expressioni

Gene expression databases

BgeeiENSMUSG00000016427 Expressed in 282 organ(s), highest expression level in choroid plexus epithelium
ExpressionAtlasiO35683 baseline and differential
GenevisibleiO35683 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiO35683
STRINGi10090.ENSMUSP00000016571

Structurei

Secondary structure

170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiO35683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA1 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J32W Eukaryota
ENOG4112BUF LUCA
GeneTreeiENSGT00390000007560
HOGENOMiHOG000010206
HOVERGENiHBG000813
InParanoidiO35683
KOiK03945
OMAiQWYLMER
OrthoDBiEOG091G179T
PhylomeDBiO35683
TreeFamiTF333394

Family and domain databases

InterProiView protein in InterPro
IPR017384 NADH_Ub_cplx-1_asu_su-1
PANTHERiPTHR17098 PTHR17098, 1 hit
PfamiView protein in Pfam
PF15879 MWFE, 1 hit
PIRSFiPIRSF038095 NDUA1, 1 hit

Sequencei

Sequence statusi: Complete.

O35683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWFEILPGLA IMGVCLVIPG VSTAYIHKFT NGGKEKRVAR VQYQWYLMER
60 70
DRRISGVNRY YVSKGLENID
Length:70
Mass (Da):8,139
Last modified:January 1, 1998 - v1
Checksum:i58CB30E72A275734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07708 mRNA Translation: CAA68977.1
BC024364 mRNA Translation: AAH24364.1
CCDSiCCDS40928.1
RefSeqiNP_062316.1, NM_019443.2
UniGeneiMm.34869

Genome annotation databases

EnsembliENSMUST00000016571; ENSMUSP00000016571; ENSMUSG00000016427
GeneIDi54405
KEGGimmu:54405
UCSCiuc009syi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07708 mRNA Translation: CAA68977.1
BC024364 mRNA Translation: AAH24364.1
CCDSiCCDS40928.1
RefSeqiNP_062316.1, NM_019443.2
UniGeneiMm.34869

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G2Jelectron microscopy3.30a1-67[»]
6G72electron microscopy3.90a1-70[»]
SMRiO35683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiO35683
STRINGi10090.ENSMUSP00000016571

PTM databases

iPTMnetiO35683
PhosphoSitePlusiO35683

Proteomic databases

EPDiO35683
PaxDbiO35683
PeptideAtlasiO35683
PRIDEiO35683

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016571; ENSMUSP00000016571; ENSMUSG00000016427
GeneIDi54405
KEGGimmu:54405
UCSCiuc009syi.1 mouse

Organism-specific databases

CTDi4694
MGIiMGI:1929511 Ndufa1

Phylogenomic databases

eggNOGiENOG410J32W Eukaryota
ENOG4112BUF LUCA
GeneTreeiENSGT00390000007560
HOGENOMiHOG000010206
HOVERGENiHBG000813
InParanoidiO35683
KOiK03945
OMAiQWYLMER
OrthoDBiEOG091G179T
PhylomeDBiO35683
TreeFamiTF333394

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSiNdufa1 mouse
PROiPR:O35683
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016427 Expressed in 282 organ(s), highest expression level in choroid plexus epithelium
ExpressionAtlasiO35683 baseline and differential
GenevisibleiO35683 MM

Family and domain databases

InterProiView protein in InterPro
IPR017384 NADH_Ub_cplx-1_asu_su-1
PANTHERiPTHR17098 PTHR17098, 1 hit
PfamiView protein in Pfam
PF15879 MWFE, 1 hit
PIRSFiPIRSF038095 NDUA1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA1_MOUSE
AccessioniPrimary (citable) accession number: O35683
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again