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Protein

Myeloid-associated differentiation marker

Gene

Myadm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid-associated differentiation marker
Alternative name(s):
Myeloid up-regulated protein
Gene namesi
Name:Myadm
Synonyms:Mug
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1355332 Myadm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568171 – 320Myeloid-associated differentiation markerAdd BLAST320

Proteomic databases

PaxDbiO35682
PeptideAtlasiO35682
PRIDEiO35682

PTM databases

iPTMnetiO35682
PhosphoSitePlusiO35682
SwissPalmiO35682

Expressioni

Gene expression databases

BgeeiENSMUSG00000068566 Expressed in 292 organ(s), highest expression level in carotid body
CleanExiMM_MYADM
ExpressionAtlasiO35682 baseline and differential
GenevisibleiO35682 MM

Interactioni

Protein-protein interaction databases

BioGridi206157, 1 interactor
IntActiO35682, 1 interactor
STRINGi10090.ENSMUSP00000094505

Structurei

3D structure databases

ProteinModelPortaliO35682
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 157MARVEL 1PROSITE-ProRule annotationAdd BLAST133
Domaini162 – 317MARVEL 2PROSITE-ProRule annotationAdd BLAST156

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00390000010832
HOGENOMiHOG000294158
HOVERGENiHBG052545
InParanoidiO35682
OMAiFPITYAC
OrthoDBiEOG091G0D9S
PhylomeDBiO35682
TreeFamiTF331088

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 2 hits
PROSITEiView protein in PROSITE
PS51225 MARVEL, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35682-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVTVTRTTI TTTTSSSTTV GSARALTQPL GLLRLLQLIS TCVAFSLVAS
60 70 80 90 100
VGAWTGPMGN WAMFTWCFCF AVTLIILIVE LGGLQAHFPL SWRNFPITFA
110 120 130 140 150
CYAALFCLSS SIIYPTTYVQ FLAHGRTRDH AIAATTFSCV ACLAYATEVA
160 170 180 190 200
WTRARPGEIT GYMATVPGLL KVFETFVACI IFAFISEPLL YNQKPALEWC
210 220 230 240 250
VAVYAICFIL AGVTILLNLG DCTNVLPIPF PTFLSGLALL SVLFYATAIV
260 270 280 290 300
LWPLYQFDQR YQGQPRRSMD PSCTRSISYI QPNTVCFWDR RLAVSILTGI
310 320
NLLAYVSDLV YSTRLVFVKV
Length:320
Mass (Da):35,285
Last modified:May 2, 2006 - v2
Checksum:i7404E588226E756E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SW94A0A0N4SW94_MOUSE
Myeloid-associated differentiation ...
Myadm
81Annotation score:

Sequence cautioni

The sequence CAA04870 differs from that shown. Reason: Frameshift at position 238.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186S → G in CAA04870 (PubMed:10733104).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001616 mRNA Translation: CAA04870.1 Frameshift.
AK052258 mRNA Translation: BAC34900.1
AK053414 mRNA Translation: BAC35377.1
AK089538 mRNA Translation: BAC40918.1
AK149962 mRNA Translation: BAE29196.1
AK159160 mRNA Translation: BAE34863.1
CCDSiCCDS51964.1
RefSeqiNP_001087233.1, NM_001093764.1
NP_001087234.1, NM_001093765.1
NP_001087235.1, NM_001093766.1
NP_058665.2, NM_016969.2
XP_006540234.1, XM_006540171.3
UniGeneiMm.29874

Genome annotation databases

EnsembliENSMUST00000096744; ENSMUSP00000094505; ENSMUSG00000068566
ENSMUST00000164553; ENSMUSP00000131318; ENSMUSG00000068566
ENSMUST00000180998; ENSMUSP00000137764; ENSMUSG00000097829
ENSMUST00000203328; ENSMUSP00000144984; ENSMUSG00000068566
ENSMUST00000203566; ENSMUSP00000145120; ENSMUSG00000068566
ENSMUST00000230914; ENSMUSP00000155763; ENSMUSG00000097829
GeneIDi50918
KEGGimmu:50918
UCSCiuc009eup.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001616 mRNA Translation: CAA04870.1 Frameshift.
AK052258 mRNA Translation: BAC34900.1
AK053414 mRNA Translation: BAC35377.1
AK089538 mRNA Translation: BAC40918.1
AK149962 mRNA Translation: BAE29196.1
AK159160 mRNA Translation: BAE34863.1
CCDSiCCDS51964.1
RefSeqiNP_001087233.1, NM_001093764.1
NP_001087234.1, NM_001093765.1
NP_001087235.1, NM_001093766.1
NP_058665.2, NM_016969.2
XP_006540234.1, XM_006540171.3
UniGeneiMm.29874

3D structure databases

ProteinModelPortaliO35682
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206157, 1 interactor
IntActiO35682, 1 interactor
STRINGi10090.ENSMUSP00000094505

PTM databases

iPTMnetiO35682
PhosphoSitePlusiO35682
SwissPalmiO35682

Proteomic databases

PaxDbiO35682
PeptideAtlasiO35682
PRIDEiO35682

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096744; ENSMUSP00000094505; ENSMUSG00000068566
ENSMUST00000164553; ENSMUSP00000131318; ENSMUSG00000068566
ENSMUST00000180998; ENSMUSP00000137764; ENSMUSG00000097829
ENSMUST00000203328; ENSMUSP00000144984; ENSMUSG00000068566
ENSMUST00000203566; ENSMUSP00000145120; ENSMUSG00000068566
ENSMUST00000230914; ENSMUSP00000155763; ENSMUSG00000097829
GeneIDi50918
KEGGimmu:50918
UCSCiuc009eup.1 mouse

Organism-specific databases

CTDi91663
MGIiMGI:1355332 Myadm

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00390000010832
HOGENOMiHOG000294158
HOVERGENiHBG052545
InParanoidiO35682
OMAiFPITYAC
OrthoDBiEOG091G0D9S
PhylomeDBiO35682
TreeFamiTF331088

Miscellaneous databases

ChiTaRSiMyadm mouse
PROiPR:O35682
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068566 Expressed in 292 organ(s), highest expression level in carotid body
CleanExiMM_MYADM
ExpressionAtlasiO35682 baseline and differential
GenevisibleiO35682 MM

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 2 hits
PROSITEiView protein in PROSITE
PS51225 MARVEL, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYADM_MOUSE
AccessioniPrimary (citable) accession number: O35682
Secondary accession number(s): Q8BGS9, Q8BPS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 2, 2006
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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