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Protein

28S ribosomal protein S12, mitochondrial

Gene

Mrps12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S12, mitochondrial
Short name:
MRP-S12
Short name:
S12mt
Alternative name(s):
MT-RPS12
Gene namesi
Name:Mrps12
Synonyms:Rpms12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1346333 Mrps12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000003060730 – 13928S ribosomal protein S12, mitochondrialAdd BLAST110

Proteomic databases

EPDiO35680
MaxQBiO35680
PaxDbiO35680
PeptideAtlasiO35680
PRIDEiO35680

PTM databases

iPTMnetiO35680
PhosphoSitePlusiO35680

Expressioni

Gene expression databases

BgeeiENSMUSG00000045948 Expressed in 282 organ(s), highest expression level in embryo
CleanExiMM_MRPS12
ExpressionAtlasiO35680 baseline and differential
GenevisibleiO35680 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi204858, 1 interactor
STRINGi10090.ENSMUSP00000062066

Structurei

3D structure databases

ProteinModelPortaliO35680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1750 Eukaryota
COG0048 LUCA
GeneTreeiENSGT00550000075103
HOGENOMiHOG000040063
HOVERGENiHBG001525
InParanoidiO35680
KOiK02950
OrthoDBiEOG091G0U3U
PhylomeDBiO35680
TreeFamiTF315095

Family and domain databases

CDDicd03368 Ribosomal_S12, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005679 Ribosomal_S12_bac
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
PRINTSiPR01034 RIBOSOMALS12
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00981 rpsL_bact, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35680-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWPGLLYGL TTSLSRGLAL APQLWAARSM ATLNQMHRLG PRKEPPKRLG
60 70 80 90 100
PTEGRPQLKG VVLRTFIRKP KKPNSANRKC CRVRLSTGKE AVCFIPGEGH
110 120 130
TLQEHHVVLV EGGRTQDLPG VKLKVVRGKY DCGHVQKKK
Length:139
Mass (Da):15,437
Last modified:January 1, 1998 - v1
Checksum:iB365FE940025EA08
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUY1E9PUY1_MOUSE
28S ribosomal protein S12, mitochon...
Mrps12
125Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11682 mRNA Translation: CAA72378.1
BC012679 mRNA Translation: AAH12679.1
BC027522 mRNA Translation: AAH27522.1
CCDSiCCDS21052.1
RefSeqiNP_036015.1, NM_011885.4
XP_006539971.1, XM_006539908.2
UniGeneiMm.358650

Genome annotation databases

EnsembliENSMUST00000056078; ENSMUSP00000062066; ENSMUSG00000045948
ENSMUST00000171183; ENSMUSP00000132443; ENSMUSG00000045948
GeneIDi24030
KEGGimmu:24030
UCSCiuc009fzo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11682 mRNA Translation: CAA72378.1
BC012679 mRNA Translation: AAH12679.1
BC027522 mRNA Translation: AAH27522.1
CCDSiCCDS21052.1
RefSeqiNP_036015.1, NM_011885.4
XP_006539971.1, XM_006539908.2
UniGeneiMm.358650

3D structure databases

ProteinModelPortaliO35680
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204858, 1 interactor
STRINGi10090.ENSMUSP00000062066

PTM databases

iPTMnetiO35680
PhosphoSitePlusiO35680

Proteomic databases

EPDiO35680
MaxQBiO35680
PaxDbiO35680
PeptideAtlasiO35680
PRIDEiO35680

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056078; ENSMUSP00000062066; ENSMUSG00000045948
ENSMUST00000171183; ENSMUSP00000132443; ENSMUSG00000045948
GeneIDi24030
KEGGimmu:24030
UCSCiuc009fzo.1 mouse

Organism-specific databases

CTDi6183
MGIiMGI:1346333 Mrps12

Phylogenomic databases

eggNOGiKOG1750 Eukaryota
COG0048 LUCA
GeneTreeiENSGT00550000075103
HOGENOMiHOG000040063
HOVERGENiHBG001525
InParanoidiO35680
KOiK02950
OrthoDBiEOG091G0U3U
PhylomeDBiO35680
TreeFamiTF315095

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

PROiPR:O35680
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045948 Expressed in 282 organ(s), highest expression level in embryo
CleanExiMM_MRPS12
ExpressionAtlasiO35680 baseline and differential
GenevisibleiO35680 MM

Family and domain databases

CDDicd03368 Ribosomal_S12, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005679 Ribosomal_S12_bac
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
PRINTSiPR01034 RIBOSOMALS12
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00981 rpsL_bact, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT12_MOUSE
AccessioniPrimary (citable) accession number: O35680
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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