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Protein

Disintegrin and metalloproteinase domain-containing protein 19

Gene

Adam19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).By similarity1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi133Zinc; in inhibited formBy similarity1
Metal bindingi346Zinc; catalytic1
Active sitei3471
Metal bindingi350Zinc; catalytic1
Metal bindingi356Zinc; catalytic1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: UniProtKB
  • SH3 domain binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8941237 Invadopodia formation

Protein family/group databases

MEROPSiM12.214

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 19 (EC:3.4.24.-)
Short name:
ADAM 19
Alternative name(s):
Meltrin-beta
Gene namesi
Name:Adam19
Synonyms:Mltnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:105377 Adam19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 703ExtracellularSequence analysisAdd BLAST677
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Topological domaini725 – 920CytoplasmicSequence analysisAdd BLAST196

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000002910427 – 204By similarityAdd BLAST178
ChainiPRO_0000029105205 – 920Disintegrin and metalloproteinase domain-containing protein 19Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi321 ↔ 404By similarity
Disulfide bondi361 ↔ 388By similarity
Disulfide bondi362 ↔ 371By similarity
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi448N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi475 ↔ 495By similarity
Glycosylationi649N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi658 ↔ 668By similarity
Disulfide bondi662 ↔ 674By similarity
Disulfide bondi676 ↔ 685By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiO35674
PaxDbiO35674
PeptideAtlasiO35674
PRIDEiO35674

PTM databases

iPTMnetiO35674
PhosphoSitePlusiO35674

Expressioni

Tissue specificityi

Widely expressed, with the highest expression in bone, heart and lung, followed by brain and spleen and relatively low expression in liver, skeletal muscle, kidney and testis. In bone, primarily expressed in cell of the osteoblast lineage and not detected in mature osteoclasts.

Developmental stagei

Expressed in the heart and in the tail bud at 8.0 dpc, and then in the cranial and dorsal root ganglia. Also expressed weakly and transiently in the intestine, lung and in bone marrow.1 Publication

Inductioni

By calcitriol and during osteoblast differentiation.

Gene expression databases

BgeeiENSMUSG00000011256 Expressed in 271 organ(s), highest expression level in decidua
ExpressionAtlasiO35674 baseline and differential
GenevisibleiO35674 MM

Interactioni

Subunit structurei

Interacts with SH3PXD2A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011400

Structurei

3D structure databases

ProteinModelPortaliO35674
SMRiO35674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 409Peptidase M12BPROSITE-ProRule annotationAdd BLAST199
Domaini417 – 503DisintegrinPROSITE-ProRule annotationAdd BLAST87
Domaini654 – 686EGF-likePROSITE-ProRule annotationAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 138Cysteine switchBy similarity8
Motifi835 – 846SH3-bindingSequence analysisAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi435 – 438Poly-Glu4
Compositional biasi504 – 653Cys-richAdd BLAST150
Compositional biasi616 – 621Poly-Glu6

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Keywords - Domaini

EGF-like domain, SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
HOGENOMiHOG000230883
HOVERGENiHBG006978
InParanoidiO35674
KOiK08608
OMAiCNRKELD
OrthoDBiEOG091G01NX
PhylomeDBiO35674
TreeFamiTF314733

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033596 ADAM19
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF19 PTHR11905:SF19, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35674-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGRAGVARF CLLALALQLH WPLAACEPGW TTRGSQEGSP PLQHELIIPQ
60 70 80 90 100
WRTSESPGRG KHPLRAELRV MAEGRELILD LEKNEHLFAP AYTETCYTAS
110 120 130 140 150
GNPQTSTLKS EDHCFYHGTV RDVDESSVTL STCRGIRGLI IVRSNLSYII
160 170 180 190 200
EPVPNSDSQH RIYRSEHLTL PPGNCGFEHS GPTSKDWALQ FTHQTKKQPR
210 220 230 240 250
RMKREDLHSM KYVELYLVAD YAEFQKNRHD QDATKRKLME IANYVDKFYR
260 270 280 290 300
SLNIRIALVG LEVWTHGDKC EVSENPYSTL WSFLSWRRKL LAQKSHDNAQ
310 320 330 340 350
LITGRSFQGT TIGLAPLMAM CSVYQSGGVS MDHSENAIGV ASTVAHEIGH
360 370 380 390 400
NFGMSHDSAH CCSASAADGG CIMAAATGHP FPKVFSWCNR KELDRYLQTG
410 420 430 440 450
GGMCLSNMPD TRTLYGGRRC GNGYLEDGEE CDCGEEEECK NPCCNASNCT
460 470 480 490 500
LKEGAECAHG SCCHQCKLVA PGTQCREQVR QCDLPEFCTG KSPHCPTNYY
510 520 530 540 550
QMDGTPCEGG QAYCYNGMCL TYQEQCQQLW GPGARPALDL CFERVNAAGD
560 570 580 590 600
TYGNCGKGLN GQYRKCSPRD AKCGKIQCQS TQARPLESNA VSIDTTITLN
610 620 630 640 650
GRRIHCRGTH VYRGPEEEEG EGDMLDPGLV MTGTKCGHNH ICFEGQCRNT
660 670 680 690 700
SFFETEGCGK KCNGHGVCNN NKNCHCFPGW SPPFCNTPGD GGSVDSGPLP
710 720 730 740 750
PKSVGPVIAG VFSALFVLAV LVLLCHCYRQ SHKLGKPSAL PFKLRHQFSC
760 770 780 790 800
PFRVSQSGGT GHANPTFKLQ TPQGKRKVTN TPESLRKPSH PPPRPPPDYL
810 820 830 840 850
RVESPPAPLP AHLNRAAGSS PEAGARIERK ESARRPPPSR PMPPAPNCLL
860 870 880 890 900
SQDFSRPRPP QKALPANPVP GQRTGPRSGG TSLLQPPTSG PQPPRPPAVP
910 920
VPKLPEYRSQ RVGAIISSKI
Length:920
Mass (Da):100,860
Last modified:November 1, 1998 - v2
Checksum:i7094FDD4EE547382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019887 mRNA Translation: AAC40037.1
D50410 mRNA Translation: BAA18923.2
CCDSiCCDS24571.1
PIRiPC7067
RefSeqiNP_033746.1, NM_009616.4
UniGeneiMm.89940

Genome annotation databases

EnsembliENSMUST00000011400; ENSMUSP00000011400; ENSMUSG00000011256
GeneIDi11492
KEGGimmu:11492
UCSCiuc007iny.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019887 mRNA Translation: AAC40037.1
D50410 mRNA Translation: BAA18923.2
CCDSiCCDS24571.1
PIRiPC7067
RefSeqiNP_033746.1, NM_009616.4
UniGeneiMm.89940

3D structure databases

ProteinModelPortaliO35674
SMRiO35674
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011400

Protein family/group databases

MEROPSiM12.214

PTM databases

iPTMnetiO35674
PhosphoSitePlusiO35674

Proteomic databases

EPDiO35674
PaxDbiO35674
PeptideAtlasiO35674
PRIDEiO35674

Protocols and materials databases

DNASUi11492
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000011400; ENSMUSP00000011400; ENSMUSG00000011256
GeneIDi11492
KEGGimmu:11492
UCSCiuc007iny.2 mouse

Organism-specific databases

CTDi8728
MGIiMGI:105377 Adam19

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
HOGENOMiHOG000230883
HOVERGENiHBG006978
InParanoidiO35674
KOiK08608
OMAiCNRKELD
OrthoDBiEOG091G01NX
PhylomeDBiO35674
TreeFamiTF314733

Enzyme and pathway databases

ReactomeiR-MMU-8941237 Invadopodia formation

Miscellaneous databases

PROiPR:O35674
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011256 Expressed in 271 organ(s), highest expression level in decidua
ExpressionAtlasiO35674 baseline and differential
GenevisibleiO35674 MM

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033596 ADAM19
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF19 PTHR11905:SF19, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA19_MOUSE
AccessioniPrimary (citable) accession number: O35674
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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