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Entry version 157 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Interferon alpha/beta receptor 2

Gene

Ifnar2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation.

By similarity

May be potent inhibitors of type I IFN receptor activity.

2 Publications

May be potent inhibitors of type I IFN receptor activity.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-909733, Interferon alpha/beta signaling
R-MMU-912694, Regulation of IFNA signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon alpha/beta receptor 2
Short name:
IFN-R-2
Short name:
IFN-alpha/beta receptor 2
Alternative name(s):
Type I interferon receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ifnar2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1098243, Ifnar2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 242ExtracellularSequence analysisAdd BLAST221
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 513CytoplasmicSequence analysisAdd BLAST250

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001100722 – 513Interferon alpha/beta receptor 2Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 123By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 93By similarity
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi210 ↔ 227By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei335PhosphotyrosineBy similarity1
Modified residuei403PhosphoserineBy similarity1
Modified residuei448PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei510PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-335 or Tyr-510 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types (By similarity).By similarity
Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O35664

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O35664

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O35664

PeptideAtlas

More...
PeptideAtlasi
O35664

PRoteomics IDEntifications database

More...
PRIDEi
O35664

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
266986 [O35664-1]
266987 [O35664-2]
266988 [O35664-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O35664, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O35664

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O35664

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Detected in liver, testis, kidney, salivary gland, thymus, brain, lung and placenta. Isoform 1, isoform 2 and isoform 3 are expressed in brain.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022971, Expressed in adult mammalian kidney and 283 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O35664, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O35664, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with IFNAR1.

Interacts with the transcriptional factors STAT1 and STAT2.

Interacts with JAK1.

Interacts with USP18; indirectly via STAT2, it negatively regulates the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and therefore type I interferon signaling.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
200539, 2 interactors

Protein interaction database and analysis system

More...
IntActi
O35664, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000023693

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O35664, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni334 – 402DisorderedSequence analysisAdd BLAST69
Regioni421 – 444Mediates interaction with STAT2 (and required for the recruitment of USP18)By similarityAdd BLAST24
Regioni458 – 513DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi334 – 354Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S60E, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000049322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_040302_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O35664

Identification of Orthologs from Complete Genome Data

More...
OMAi
TGDGYIM

Database of Orthologous Groups

More...
OrthoDBi
680035at2759

TreeFam database of animal gene trees

More...
TreeFami
TF335897

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR015373, Interferon/interleukin_rcp_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09294, Interfer-bind, 1 hit
PF01108, Tissue_fac, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O35664-1) [UniParc]FASTAAdd to basket
Also known as: IFNaR2c

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSRCTVSAV GLLSLCLVVS ASLETITPSA FDGYPDEPCT INITIRNSRL
60 70 80 90 100
ILSWELENKS GPPANYTLWY TVMSKDENLT KVKNCSDTTK SSCDVTDKWL
110 120 130 140 150
EGMESYVVAI VIVHRGDLTV CRCSDYIVPA NAPLEPPEFE IVGFTDHINV
160 170 180 190 200
TMEFPPVTSK IIQEKMKTTP FVIKEQIGDS VRKKHEPKVN NVTGNFTFVL
210 220 230 240 250
RDLLPKTNYC VSLYFDDDPA IKSPLKCIVL QPGQESGLSE SAIVGITTSC
260 270 280 290 300
LVVMVFVSTI VMLKRIGYIC LKDNLPNVLN FRHFLTWIIP ERSPSEAIDR
310 320 330 340 350
LEIIPTNKKK RLWNYDYEDG SDSDEEVPTA SVTGYTMHGL TGKPLQQTSD
360 370 380 390 400
TSASPEDPLH EEDSGAEESD EAGAGAGAEP ELPTEAGAGP SEDPTGPYER
410 420 430 440 450
RKSVLEDSFP REDNSSMDEP GDNIIFNVNL NSVFLRVLHD EDASETLSLE
460 470 480 490 500
EDTILLDEGP QRTESDLRIA GGDRTQPPLP SLPSQDLWTE DGSSEKSDTS
510
DSDADVGDGY IMR
Length:513
Mass (Da):56,578
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A645DA5F33C9EA0
GO
Isoform 2 (identifier: O35664-2) [UniParc]FASTAAdd to basket
Also known as: IFNaR2b

The sequence of this isoform differs from the canonical sequence as follows:
     237-247: GLSESAIVGIT → ELPPLFNLDNP
     248-513: Missing.

Note: Probable soluble receptor.Curated
Show »
Length:247
Mass (Da):27,610
Checksum:i4957A16710C2D2D1
GO
Isoform 3 (identifier: O35664-3) [UniParc]FASTAAdd to basket
Also known as: IFNaR2a

The sequence of this isoform differs from the canonical sequence as follows:
     238-248: LSESAIVGITT → MARFLKFALLF
     249-513: Missing.

Note: Probable soluble receptor.Curated
Show »
Length:248
Mass (Da):27,755
Checksum:i47D6008193F7BC3C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJ04H3BJ04_MOUSE
Interferon alpha/beta receptor 2
Ifnar2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKB3H3BKB3_MOUSE
Interferon alpha/beta receptor 2
Ifnar2
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160K → Q in CAA70992 (PubMed:9322767).Curated1
Sequence conflicti276P → S in CAA70992 (PubMed:9322767).Curated1
Sequence conflicti339G → E in AAC53351 (PubMed:9295335).Curated1
Sequence conflicti429N → S in AAC53351 (PubMed:9295335).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050345237 – 247GLSESAIVGIT → ELPPLFNLDNP in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_050346238 – 248LSESAIVGITT → MARFLKFALLF in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_050347248 – 513Missing in isoform 2. 1 PublicationAdd BLAST266
Alternative sequenceiVSP_050348249 – 513Missing in isoform 3. 2 PublicationsAdd BLAST265

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y09813 mRNA Translation: CAA70943.1
Y09864 mRNA Translation: CAA70991.1
Y09865 mRNA Translation: CAA70992.1
AF013274 mRNA Translation: AAC53351.1
AF013486 mRNA Translation: AAC53352.1
AF367979 Genomic DNA Translation: AAK73024.1
AK139169 mRNA Translation: BAE23909.1
AK151474 mRNA Translation: BAE30430.1
AK152878 mRNA Translation: BAE31563.1
AK153317 mRNA Translation: BAE31897.1
CH466602 Genomic DNA Translation: EDL03831.1
BC071225 mRNA Translation: AAH71225.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28325.1 [O35664-1]
CCDS49910.1 [O35664-3]
CCDS84262.1 [O35664-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001103968.1, NM_001110498.1 [O35664-3]
NP_001334187.1, NM_001347258.1 [O35664-2]
NP_034639.2, NM_010509.2 [O35664-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000023693; ENSMUSP00000023693; ENSMUSG00000022971 [O35664-1]
ENSMUST00000089042; ENSMUSP00000086443; ENSMUSG00000022971 [O35664-2]
ENSMUST00000117836; ENSMUSP00000113358; ENSMUSG00000022971 [O35664-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
15976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:15976

UCSC genome browser

More...
UCSCi
uc007zxh.2, mouse [O35664-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09813 mRNA Translation: CAA70943.1
Y09864 mRNA Translation: CAA70991.1
Y09865 mRNA Translation: CAA70992.1
AF013274 mRNA Translation: AAC53351.1
AF013486 mRNA Translation: AAC53352.1
AF367979 Genomic DNA Translation: AAK73024.1
AK139169 mRNA Translation: BAE23909.1
AK151474 mRNA Translation: BAE30430.1
AK152878 mRNA Translation: BAE31563.1
AK153317 mRNA Translation: BAE31897.1
CH466602 Genomic DNA Translation: EDL03831.1
BC071225 mRNA Translation: AAH71225.1
CCDSiCCDS28325.1 [O35664-1]
CCDS49910.1 [O35664-3]
CCDS84262.1 [O35664-2]
RefSeqiNP_001103968.1, NM_001110498.1 [O35664-3]
NP_001334187.1, NM_001347258.1 [O35664-2]
NP_034639.2, NM_010509.2 [O35664-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi200539, 2 interactors
IntActiO35664, 2 interactors
STRINGi10090.ENSMUSP00000023693

PTM databases

GlyGeniO35664, 8 sites
iPTMnetiO35664
PhosphoSitePlusiO35664

Proteomic databases

jPOSTiO35664
MaxQBiO35664
PaxDbiO35664
PeptideAtlasiO35664
PRIDEiO35664
ProteomicsDBi266986 [O35664-1]
266987 [O35664-2]
266988 [O35664-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
15976

Genome annotation databases

EnsembliENSMUST00000023693; ENSMUSP00000023693; ENSMUSG00000022971 [O35664-1]
ENSMUST00000089042; ENSMUSP00000086443; ENSMUSG00000022971 [O35664-2]
ENSMUST00000117836; ENSMUSP00000113358; ENSMUSG00000022971 [O35664-3]
GeneIDi15976
KEGGimmu:15976
UCSCiuc007zxh.2, mouse [O35664-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3455
MGIiMGI:1098243, Ifnar2

Phylogenomic databases

eggNOGiENOG502S60E, Eukaryota
GeneTreeiENSGT00510000049322
HOGENOMiCLU_040302_0_0_1
InParanoidiO35664
OMAiTGDGYIM
OrthoDBi680035at2759
TreeFamiTF335897

Enzyme and pathway databases

ReactomeiR-MMU-909733, Interferon alpha/beta signaling
R-MMU-912694, Regulation of IFNA signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
15976, 11 hits in 56 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ifnar2, mouse

Protein Ontology

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PROi
PR:O35664
RNActiO35664, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000022971, Expressed in adult mammalian kidney and 283 other tissues
ExpressionAtlasiO35664, baseline and differential
GenevisibleiO35664, MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR015373, Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294, Interfer-bind, 1 hit
PF01108, Tissue_fac, 1 hit
SUPFAMiSSF49265, SSF49265, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINAR2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35664
Secondary accession number(s): O35238
, O35663, O35983, Q923Z5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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