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Protein

Interferon alpha/beta receptor 2

Gene

Ifnar2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 2 and isoform 3 may be potent inhibitors of type I IFN receptor activity.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha/beta receptor 2
Short name:
IFN-R-2
Short name:
IFN-alpha/beta receptor 2
Alternative name(s):
Type I interferon receptor 2
Gene namesi
Name:Ifnar2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1098243 Ifnar2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 242ExtracellularSequence analysisAdd BLAST221
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 513CytoplasmicSequence analysisAdd BLAST250

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001100722 – 513Interferon alpha/beta receptor 2Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 123By similarity
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 93By similarity
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi210 ↔ 227By similarity
Modified residuei335PhosphotyrosineBy similarity1
Modified residuei403PhosphoserineBy similarity1
Modified residuei448PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei510PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-335 or Tyr-510 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types (By similarity).By similarity
Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35664
PaxDbiO35664
PeptideAtlasiO35664
PRIDEiO35664

PTM databases

iPTMnetiO35664
PhosphoSitePlusiO35664

Expressioni

Tissue specificityi

Widely expressed. Detected in liver, testis, kidney, salivary gland, thymus, brain, lung and placenta. Isoform 1, isoform 2 and isoform 3 are expressed in brain.2 Publications

Gene expression databases

BgeeiENSMUSG00000022971 Expressed in 258 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_IFNAR2
ExpressionAtlasiO35664 baseline and differential
GenevisibleiO35664 MM

Interactioni

Subunit structurei

Heterodimer with IFNAR1. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200539, 2 interactors
IntActiO35664, 2 interactors
STRINGi10090.ENSMUSP00000023693

Structurei

3D structure databases

ProteinModelPortaliO35664
SMRiO35664
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHB9 Eukaryota
ENOG410YTXY LUCA
GeneTreeiENSGT00510000049322
HOGENOMiHOG000013219
HOVERGENiHBG052127
InParanoidiO35664
KOiK05131
OMAiRVGYICL
OrthoDBiEOG091G09YY
TreeFamiTF335897

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O35664-1) [UniParc]FASTAAdd to basket
Also known as: IFNaR2c

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSRCTVSAV GLLSLCLVVS ASLETITPSA FDGYPDEPCT INITIRNSRL
60 70 80 90 100
ILSWELENKS GPPANYTLWY TVMSKDENLT KVKNCSDTTK SSCDVTDKWL
110 120 130 140 150
EGMESYVVAI VIVHRGDLTV CRCSDYIVPA NAPLEPPEFE IVGFTDHINV
160 170 180 190 200
TMEFPPVTSK IIQEKMKTTP FVIKEQIGDS VRKKHEPKVN NVTGNFTFVL
210 220 230 240 250
RDLLPKTNYC VSLYFDDDPA IKSPLKCIVL QPGQESGLSE SAIVGITTSC
260 270 280 290 300
LVVMVFVSTI VMLKRIGYIC LKDNLPNVLN FRHFLTWIIP ERSPSEAIDR
310 320 330 340 350
LEIIPTNKKK RLWNYDYEDG SDSDEEVPTA SVTGYTMHGL TGKPLQQTSD
360 370 380 390 400
TSASPEDPLH EEDSGAEESD EAGAGAGAEP ELPTEAGAGP SEDPTGPYER
410 420 430 440 450
RKSVLEDSFP REDNSSMDEP GDNIIFNVNL NSVFLRVLHD EDASETLSLE
460 470 480 490 500
EDTILLDEGP QRTESDLRIA GGDRTQPPLP SLPSQDLWTE DGSSEKSDTS
510
DSDADVGDGY IMR
Length:513
Mass (Da):56,578
Last modified:July 27, 2011 - v2
Checksum:i7A645DA5F33C9EA0
GO
Isoform 2 (identifier: O35664-2) [UniParc]FASTAAdd to basket
Also known as: IFNaR2b

The sequence of this isoform differs from the canonical sequence as follows:
     237-247: GLSESAIVGIT → ELPPLFNLDNP
     248-513: Missing.

Note: Probable soluble receptor.
Show »
Length:247
Mass (Da):27,610
Checksum:i4957A16710C2D2D1
GO
Isoform 3 (identifier: O35664-3) [UniParc]FASTAAdd to basket
Also known as: IFNaR2a

The sequence of this isoform differs from the canonical sequence as follows:
     238-248: LSESAIVGITT → MARFLKFALLF
     249-513: Missing.

Note: Probable soluble receptor.
Show »
Length:248
Mass (Da):27,755
Checksum:i47D6008193F7BC3C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJ04H3BJ04_MOUSE
Interferon alpha/beta receptor 2
Ifnar2
117Annotation score:
H3BKB3H3BKB3_MOUSE
Interferon alpha/beta receptor 2
Ifnar2
48Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160K → Q in CAA70992 (PubMed:9322767).Curated1
Sequence conflicti276P → S in CAA70992 (PubMed:9322767).Curated1
Sequence conflicti339G → E in AAC53351 (PubMed:9295335).Curated1
Sequence conflicti429N → S in AAC53351 (PubMed:9295335).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050345237 – 247GLSESAIVGIT → ELPPLFNLDNP in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_050346238 – 248LSESAIVGITT → MARFLKFALLF in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_050347248 – 513Missing in isoform 2. 1 PublicationAdd BLAST266
Alternative sequenceiVSP_050348249 – 513Missing in isoform 3. 2 PublicationsAdd BLAST265

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09813 mRNA Translation: CAA70943.1
Y09864 mRNA Translation: CAA70991.1
Y09865 mRNA Translation: CAA70992.1
AF013274 mRNA Translation: AAC53351.1
AF013486 mRNA Translation: AAC53352.1
AF367979 Genomic DNA Translation: AAK73024.1
AK139169 mRNA Translation: BAE23909.1
AK151474 mRNA Translation: BAE30430.1
AK152878 mRNA Translation: BAE31563.1
AK153317 mRNA Translation: BAE31897.1
CH466602 Genomic DNA Translation: EDL03831.1
BC071225 mRNA Translation: AAH71225.1
CCDSiCCDS28325.1 [O35664-1]
CCDS49910.1 [O35664-3]
CCDS84262.1 [O35664-2]
RefSeqiNP_001103968.1, NM_001110498.1 [O35664-3]
NP_001334187.1, NM_001347258.1 [O35664-2]
NP_034639.2, NM_010509.2 [O35664-1]
UniGeneiMm.6834

Genome annotation databases

EnsembliENSMUST00000023693; ENSMUSP00000023693; ENSMUSG00000022971 [O35664-1]
ENSMUST00000089042; ENSMUSP00000086443; ENSMUSG00000022971 [O35664-2]
ENSMUST00000117836; ENSMUSP00000113358; ENSMUSG00000022971 [O35664-3]
GeneIDi15976
KEGGimmu:15976
UCSCiuc007zxh.2 mouse [O35664-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09813 mRNA Translation: CAA70943.1
Y09864 mRNA Translation: CAA70991.1
Y09865 mRNA Translation: CAA70992.1
AF013274 mRNA Translation: AAC53351.1
AF013486 mRNA Translation: AAC53352.1
AF367979 Genomic DNA Translation: AAK73024.1
AK139169 mRNA Translation: BAE23909.1
AK151474 mRNA Translation: BAE30430.1
AK152878 mRNA Translation: BAE31563.1
AK153317 mRNA Translation: BAE31897.1
CH466602 Genomic DNA Translation: EDL03831.1
BC071225 mRNA Translation: AAH71225.1
CCDSiCCDS28325.1 [O35664-1]
CCDS49910.1 [O35664-3]
CCDS84262.1 [O35664-2]
RefSeqiNP_001103968.1, NM_001110498.1 [O35664-3]
NP_001334187.1, NM_001347258.1 [O35664-2]
NP_034639.2, NM_010509.2 [O35664-1]
UniGeneiMm.6834

3D structure databases

ProteinModelPortaliO35664
SMRiO35664
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200539, 2 interactors
IntActiO35664, 2 interactors
STRINGi10090.ENSMUSP00000023693

PTM databases

iPTMnetiO35664
PhosphoSitePlusiO35664

Proteomic databases

MaxQBiO35664
PaxDbiO35664
PeptideAtlasiO35664
PRIDEiO35664

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023693; ENSMUSP00000023693; ENSMUSG00000022971 [O35664-1]
ENSMUST00000089042; ENSMUSP00000086443; ENSMUSG00000022971 [O35664-2]
ENSMUST00000117836; ENSMUSP00000113358; ENSMUSG00000022971 [O35664-3]
GeneIDi15976
KEGGimmu:15976
UCSCiuc007zxh.2 mouse [O35664-1]

Organism-specific databases

CTDi3455
MGIiMGI:1098243 Ifnar2

Phylogenomic databases

eggNOGiENOG410IHB9 Eukaryota
ENOG410YTXY LUCA
GeneTreeiENSGT00510000049322
HOGENOMiHOG000013219
HOVERGENiHBG052127
InParanoidiO35664
KOiK05131
OMAiRVGYICL
OrthoDBiEOG091G09YY
TreeFamiTF335897

Enzyme and pathway databases

ReactomeiR-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

Miscellaneous databases

ChiTaRSiIfnar2 mouse
PROiPR:O35664
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022971 Expressed in 258 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_IFNAR2
ExpressionAtlasiO35664 baseline and differential
GenevisibleiO35664 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiINAR2_MOUSE
AccessioniPrimary (citable) accession number: O35664
Secondary accession number(s): O35238
, O35663, O35983, Q923Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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