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Protein

Glutathione S-transferase Mu 6

Gene

Gstm6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 6 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 6
Glutathione-S-transferase class M5
Gene namesi
Name:Gstm6
Synonyms:Gstm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1309467 Gstm6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858301 – 218Glutathione S-transferase Mu 6Add BLAST218

Proteomic databases

PaxDbiO35660
PRIDEiO35660

PTM databases

iPTMnetiO35660
PhosphoSitePlusiO35660

Expressioni

Tissue specificityi

Expressed in liver, stomach and small intestine. Not expressed in spleen, kidney, colon, heart, muscle, brain or lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000068762
CleanExiMM_GSTM5
MM_GSTM6
ExpressionAtlasiO35660 baseline and differential
GenevisibleiO35660 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102296

Structurei

3D structure databases

ProteinModelPortaliO35660
SMRiO35660
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88GST N-terminalAdd BLAST88
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni46 – 50Glutathione bindingBy similarity5
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J Eukaryota
ENOG4110YU0 LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115735
HOVERGENiHBG106842
InParanoidiO35660
KOiK00799

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003081 GST_mu
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01267 GSTRNSFRASEM
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

O35660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVTLGYWDI RGLGHAIRLL LEYTETGYEE KRYAMGDAPD YDRSQWLNDK
60 70 80 90 100
FKLDLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDIL
110 120 130 140 150
EKQVMDTRIQ MGMLCYSADF EKRKPEFLKG LPDQLKLYSE FLGKQPWFAG
160 170 180 190 200
DKITFADFLV YDVLDQHRMF EPTCLDAFPN LKDFMARFEG LRKISAYMKT
210
SRFLPSPVYL KQATWGNE
Length:218
Mass (Da):25,621
Last modified:April 29, 2015 - v4
Checksum:iDEA0AF7056F88638
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31K → R in CAA04060 (PubMed:9480867).Curated1
Sequence conflicti31K → R in CAA04061 (PubMed:9480867).Curated1
Sequence conflicti54D → G in CAA04060 (PubMed:9480867).Curated1
Sequence conflicti102 – 103KQ → NR in CAA04061 (PubMed:9480867).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000413 mRNA Translation: CAA04061.1
AJ000412 Genomic DNA Translation: CAA04060.1
AC079042 Genomic DNA No translation available.
BC031818 mRNA Translation: AAH31818.1
CCDSiCCDS38596.1
RefSeqiNP_032210.3, NM_008184.3
UniGeneiMm.458154

Genome annotation databases

EnsembliENSMUST00000106685; ENSMUSP00000102296; ENSMUSG00000068762
GeneIDi14867
KEGGimmu:14867

Similar proteinsi

Entry informationi

Entry nameiGSTM6_MOUSE
AccessioniPrimary (citable) accession number: O35660
Secondary accession number(s): O35661, Q8K0C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: April 29, 2015
Last modified: May 23, 2018
This is version 131 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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