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Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:9568699). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (By similarity). Plays a role in regulating insulin secretion in response to GLP-1 (PubMed:9568699).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:Glp1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:99571 Glp1r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 139ExtracellularCuratedAdd BLAST118
Transmembranei140 – 164Helical; Name=1By similarityAdd BLAST25
Topological domaini165 – 175CytoplasmicCuratedAdd BLAST11
Transmembranei176 – 201Helical; Name=2By similarityAdd BLAST26
Topological domaini202 – 227ExtracellularCuratedAdd BLAST26
Transmembranei228 – 251Helical; Name=3By similarityAdd BLAST24
Topological domaini252 – 265CytoplasmicCuratedAdd BLAST14
Transmembranei266 – 290Helical; Name=4By similarityAdd BLAST25
Topological domaini291 – 305ExtracellularCuratedAdd BLAST15
Transmembranei306 – 328Helical; Name=5By similarityAdd BLAST23
Topological domaini329 – 348CytoplasmicCuratedAdd BLAST20
Transmembranei349 – 370Helical; Name=6By similarityAdd BLAST22
Topological domaini371 – 383ExtracellularCuratedAdd BLAST13
Transmembranei384 – 404Helical; Name=7By similarityAdd BLAST21
Topological domaini405 – 463CytoplasmicCuratedAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075290

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001283622 – 463Glucagon-like peptide 1 receptorAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 71By similarity
Disulfide bondi62 ↔ 104By similarity
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 126By similarity
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi226 ↔ 296By similarity
Modified residuei341ADP-ribosylcysteineBy similarity1
Modified residuei348ADP-ribosylarginineBy similarity1

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35659
PRIDEiO35659

PTM databases

iPTMnetiO35659
PhosphoSitePlusiO35659

Expressioni

Tissue specificityi

Detected in pancreatic islets (at protein level). Detected in pancreatic islets and lungs.1 Publication

Gene expression databases

BgeeiENSMUSG00000024027
CleanExiMM_GLP1R
GenevisibleiO35659 MM

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei121Interaction with the endogenous ligand GLP-1By similarity1
Sitei128Interaction with the endogenous ligand GLP-1By similarity1

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110221

Chemistry databases

BindingDBiO35659

Structurei

3D structure databases

ProteinModelPortaliO35659
SMRiO35659
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni352 – 355Important for allosteric inhibitor bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiO35659
KOiK04581
OMAiRNSNMNY
OrthoDBiEOG091G0NF8
TreeFamiTF315710

Family and domain databases

CDDicd15268 7tmB1_GLP1R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003290 GPCR_2_GLP1/glucagon_rcpt
IPR003292 GPCR_2_GLP1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF245 PTHR12011:SF245, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01353 GLUCAGNFAMLY
PR01355 GLUCAGNLIKER
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTPSLLRL ALLLLGAVGR AGPRPQGTTV SLSETVQKWR EYRRQCQRFL
60 70 80 90 100
TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV
110 120 130 140 150
YRFCTAEGLW LHKDNSSLPW RDLSECEESK RGERNFPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILVGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLIFIRVICI VVSKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI
410 420 430 440 450
LYCFVNNEVQ MEFRKCWERW RLEHLNIQRD CSMKPLKCPT SSVSSGATVG
460
SSVYAATCQS SYS
Length:463
Mass (Da):53,028
Last modified:October 16, 2013 - v2
Checksum:iFBA3D9D79A30E9C3
GO

Sequence cautioni

The sequence CAA04930 differs from that shown. Reason: Frameshift at position 450.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001692 mRNA Translation: CAA04930.1 Frameshift.
DQ093397 mRNA Translation: AAZ83365.1
AY293742 mRNA Translation: AAQ54583.1
AC165951 Genomic DNA No translation available.
BC139464 mRNA Translation: AAI39465.1
BC139466 mRNA Translation: AAI39467.1
CCDSiCCDS37542.1
RefSeqiNP_067307.2, NM_021332.2
UniGeneiMm.390969

Genome annotation databases

EnsembliENSMUST00000114574; ENSMUSP00000110221; ENSMUSG00000024027
GeneIDi14652
KEGGimmu:14652
UCSCiuc008bud.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGLP1R_MOUSE
AccessioniPrimary (citable) accession number: O35659
Secondary accession number(s): Q1JQR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: June 20, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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