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Protein

Calpain-6

Gene

Capn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.2 Publications

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • microtubule binding Source: UniProtKB

GO - Biological processi

  • microtubule bundle formation Source: UniProtKB
  • proteolysis Source: GO_Central
  • regulation of cytoskeleton organization Source: UniProtKB

Enzyme and pathway databases

BRENDAi3.4.22.B26 3474
ReactomeiR-MMU-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.971

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-6
Gene namesi
Name:Capn6
Synonyms:Capa6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1100850 Capn6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077181 – 641Calpain-6Add BLAST641

Proteomic databases

MaxQBiO35646
PaxDbiO35646
PeptideAtlasiO35646
PRIDEiO35646

PTM databases

iPTMnetiO35646
PhosphoSitePlusiO35646

Expressioni

Developmental stagei

At E10.5 expressed in the mandibular arches, heart and limb buds.1 Publication

Inductioni

Up-regulated during the osteoclasogenic process. Inhibited by dexamethaxone during the osteoclasogenic process.1 Publication

Gene expression databases

BgeeiENSMUSG00000067276
CleanExiMM_CAPN6
GenevisibleiO35646 MM

Interactioni

Subunit structurei

Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198475, 2 interactors
IntActiO35646, 1 interactor
MINTiO35646
STRINGi10090.ENSMUSP00000084573

Structurei

3D structure databases

ProteinModelPortaliO35646
SMRiO35646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 343Calpain catalyticPROSITE-ProRule annotationAdd BLAST318
Domaini518 – 620C2Add BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 495Domain IIIAdd BLAST152

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000232036
HOVERGENiHBG001095
InParanoidiO35646
KOiK08575
OMAiEQEWDPR
OrthoDBiEOG091G030A
TreeFamiTF314748

Family and domain databases

CDDicd04046 C2_Calpain, 1 hit
cd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR033884 C2_Calpain
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR029540 CAPN6
IPR038765 Papain_like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF381 PTHR10183:SF381, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

Sequencei

Sequence statusi: Complete.

O35646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPLKLFKN QKYQELKQEC MKDGRLFCDP TFLPENDSLF FNRLLPGKVV
60 70 80 90 100
WKRPQDISDD PHLIVGNISN HQLIQGRLGN KAMISAFSCL AVQESHWTKA
110 120 130 140 150
IPNHKDQEWD PRKPEKYAGI FHFRFWHFGE WTEVVIDDLL PTINGDLVFS
160 170 180 190 200
FSTSMNEFWN ALLEKAYAKL LGCYEALDGL TITDIIMDFT GTLAEIIDMQ
210 220 230 240 250
KGRYTDLVEE KYKLFGELYK TFTKGGLICC SIESPSQEEQ EVETDWGLLK
260 270 280 290 300
GYTYTMTDIR KLRLGERLVE VFSTEKLYMV RLRNPLGRQE WSGPWSEISE
310 320 330 340 350
EWQQLTVTDR KNLGLVMSDD GEFWMSLEDF CHNFHKLNVC RNVNNPVFGR
360 370 380 390 400
KELESVVGCW TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM
410 420 430 440 450
SLQQKDLRTY RRMGRPDNYI IGFELFKVEM NRRFRLHHLY IQERAGTSTY
460 470 480 490 500
IDTRTVFLSK YLKKGSYVLV PTMFQHGRTS EFLLRIFSEV PVQLRELTLD
510 520 530 540 550
MPKMSCWNLA RGYPKVVTQI TVHSAEGLEK KYANETVNPY LIIKCGKEEV
560 570 580 590 600
RSPVQKNTVH AIFDTQAIFY RRTTDIPIII QVWNSRKFCD QFLGQVTLDA
610 620 630 640
DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L
Length:641
Mass (Da):74,543
Last modified:July 27, 2011 - v2
Checksum:i3F7D8DBC615B57A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti568I → V in CAA73161 (PubMed:9503024).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12582 mRNA Translation: CAA73161.1
AK145116 mRNA Translation: BAE26243.1
BX530055 Genomic DNA No translation available.
CCDSiCCDS30455.1
RefSeqiNP_031629.3, NM_007603.3
UniGeneiMm.30290

Genome annotation databases

EnsembliENSMUST00000087316; ENSMUSP00000084573; ENSMUSG00000067276
GeneIDi12338
KEGGimmu:12338
UCSCiuc009umk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCAN6_MOUSE
AccessioniPrimary (citable) accession number: O35646
Secondary accession number(s): Q3UM55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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