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Protein

AP-1 complex subunit beta-1

Gene

Ap1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Molecular functioni

  • clathrin binding Source: InterPro
  • protein kinase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • clathrin coat assembly Source: MGI
  • determination of left/right symmetry Source: MGI
  • heart development Source: MGI
  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit beta-1
Alternative name(s):
Adaptor protein complex AP-1 subunit beta-1
Adaptor-related protein complex 1 subunit beta-1
Beta-1-adaptin
Beta-adaptin 1
Clathrin assembly protein complex 1 beta large chain
Golgi adaptor HA1/AP1 adaptin beta subunit
Gene namesi
Name:Ap1b1
Synonyms:Adtb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1096368 Ap1b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937391 – 943AP-1 complex subunit beta-1Add BLAST943

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318N6-acetyllysineBy similarity1
Modified residuei574Nitrated tyrosineCombined sources1

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

EPDiO35643
MaxQBiO35643
PaxDbiO35643
PeptideAtlasiO35643
PRIDEiO35643

PTM databases

iPTMnetiO35643
PhosphoSitePlusiO35643
SwissPalmiO35643

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000009090 Expressed in 281 organ(s), highest expression level in cerebellum
CleanExiMM_AP1B1
ExpressionAtlasiO35643 baseline and differential
GenevisibleiO35643 MM

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198122, 9 interactors
CORUMiO35643
IntActiO35643, 9 interactors
STRINGi10090.ENSMUSP00000009234

Structurei

3D structure databases

ProteinModelPortaliO35643
SMRiO35643
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi576 – 722Pro-rich (stalk region)Add BLAST147

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1061 Eukaryota
COG5096 LUCA
GeneTreeiENSGT00530000063138
HOGENOMiHOG000163270
HOVERGENiHBG050515
InParanoidiO35643
KOiK12392
OMAiGPNFVAP
OrthoDBiEOG091G019U
TreeFamiTF300318

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PF09066 B2-adapt-app_C, 1 hit
PIRSFiPIRSF002291 AP_complex_beta, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM00185 ARM, 2 hits
SM01020 B2-adapt-app_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35643-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL
60 70 80 90 100
FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP
110 120 130 140 150
LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD
160 170 180 190 200
INAQLVEDQG FLDTLKDLIS DSNPMVVANA VAALSEIAES HPSSNLLDLN
210 220 230 240 250
PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI CERVTPRLSH
260 270 280 290 300
ANSAVVLSAV KVLMKFMEML SKDLDYYATL LKKLAPPLVT LLSAEPELQY
310 320 330 340 350
VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN
360 370 380 390 400
IAQVLAELKE YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ
410 420 430 440 450
TKVNYVVQEA IVVIKDIFRK YPNKYESVIA TLCENLDSLD EPEARAAMIW
460 470 480 490 500
IVGEYAERID NADELLESFL EGFHDESTQV QLQLLTAIVK LFLKKPTETQ
510 520 530 540 550
ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV VLAEKPLISE
560 570 580 590 600
ETDLIEPTLL DELICYIGTL ASVYHKPPNA FVEGGRGVVH KSLPPRTASS
610 620 630 640 650
ESTESPETAP AGAPAGDQPD VIPAQGDLLG DLLNLDLGPP VSGPPLAASS
660 670 680 690 700
VQMGAVDLLG GGLDSLIGDS NFGAPSASVA AAPAPARLGA PISSGLSDLF
710 720 730 740 750
DLTSGVGTLS GSYVAPKAVW LPAMKAKGLE ISGTFTRQAG SISMDLQLTN
760 770 780 790 800
KALQVMTDFA IQFNRNSFGL APAAPLQVHV PLSPNQTVEI SLPLNTVGSV
810 820 830 840 850
LKMEPLNNLQ VAVKNNIDVF YFSTLYPLHV LFVEDGKMDR QMFLATWKDI
860 870 880 890 900
ANENEAQFQI RDCPLNTEAA SNKLQSSNIF TVAKRNVEGQ DMLYQSLKLT
910 920 930 940
NGIWVLAELR IQPGNPSFTL SLKCRAPEVS QHVYQAYETI LKN
Length:943
Mass (Da):103,935
Last modified:July 27, 2011 - v2
Checksum:i5DD1951EAAC20225
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SVG4Q5SVG4_MOUSE
AP complex subunit beta
Ap1b1
923Annotation score:
Q5SVG5Q5SVG5_MOUSE
AP complex subunit beta
Ap1b1
916Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227A → D in CAA69224 (PubMed:9271666).Curated1
Sequence conflicti288L → P in AAH08513 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07919 mRNA Translation: CAA69224.1
AK159273 mRNA Translation: BAE34952.1
CH466574 Genomic DNA Translation: EDL40509.1
BC008513 mRNA Translation: AAH08513.1
CCDSiCCDS36100.1
RefSeqiNP_031480.2, NM_007454.3
UniGeneiMm.274816

Genome annotation databases

EnsembliENSMUST00000009234; ENSMUSP00000009234; ENSMUSG00000009090
GeneIDi11764
KEGGimmu:11764
UCSCiuc007hvo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07919 mRNA Translation: CAA69224.1
AK159273 mRNA Translation: BAE34952.1
CH466574 Genomic DNA Translation: EDL40509.1
BC008513 mRNA Translation: AAH08513.1
CCDSiCCDS36100.1
RefSeqiNP_031480.2, NM_007454.3
UniGeneiMm.274816

3D structure databases

ProteinModelPortaliO35643
SMRiO35643
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198122, 9 interactors
CORUMiO35643
IntActiO35643, 9 interactors
STRINGi10090.ENSMUSP00000009234

PTM databases

iPTMnetiO35643
PhosphoSitePlusiO35643
SwissPalmiO35643

Proteomic databases

EPDiO35643
MaxQBiO35643
PaxDbiO35643
PeptideAtlasiO35643
PRIDEiO35643

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009234; ENSMUSP00000009234; ENSMUSG00000009090
GeneIDi11764
KEGGimmu:11764
UCSCiuc007hvo.2 mouse

Organism-specific databases

CTDi162
MGIiMGI:1096368 Ap1b1

Phylogenomic databases

eggNOGiKOG1061 Eukaryota
COG5096 LUCA
GeneTreeiENSGT00530000063138
HOGENOMiHOG000163270
HOVERGENiHBG050515
InParanoidiO35643
KOiK12392
OMAiGPNFVAP
OrthoDBiEOG091G019U
TreeFamiTF300318

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRSiAp1b1 mouse
PROiPR:O35643
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009090 Expressed in 281 organ(s), highest expression level in cerebellum
CleanExiMM_AP1B1
ExpressionAtlasiO35643 baseline and differential
GenevisibleiO35643 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PF09066 B2-adapt-app_C, 1 hit
PIRSFiPIRSF002291 AP_complex_beta, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM00185 ARM, 2 hits
SM01020 B2-adapt-app_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP1B1_MOUSE
AccessioniPrimary (citable) accession number: O35643
Secondary accession number(s): Q3TXG4, Q922E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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