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Protein

Annexin A8

Gene

Anxa8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi266Calcium; via carbonyl oxygenBy similarity1
Metal bindingi268Calcium; via carbonyl oxygenBy similarity1
Metal bindingi270Calcium; via carbonyl oxygenBy similarity1
Metal bindingi310CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Calcium/phospholipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A8
Alternative name(s):
Annexin VIII
Annexin-8
Gene namesi
Name:Anxa8
Synonyms:Anx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1201374 Anxa8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675041 – 327Annexin A8Add BLAST327

Proteomic databases

MaxQBiO35640
PaxDbiO35640
PeptideAtlasiO35640
PRIDEiO35640

PTM databases

iPTMnetiO35640
PhosphoSitePlusiO35640

Expressioni

Gene expression databases

BgeeiENSMUSG00000021950 Expressed in 161 organ(s), highest expression level in ear
CleanExiMM_ANXA8
ExpressionAtlasiO35640 baseline and differential
GenevisibleiO35640 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO35640
SMRiO35640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 90Annexin 1Add BLAST53
Repeati110 – 162Annexin 2Add BLAST53
Repeati195 – 247Annexin 3Add BLAST53
Repeati270 – 322Annexin 4Add BLAST53

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiO35640
KOiK17096
OMAiKGSPHFN
OrthoDBiEOG091G0H6H
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR009115 ANX8
PANTHERiPTHR10502:SF133 PTHR10502:SF133, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01808 ANNEXINVIII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35640-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWWKAWVEQ EGVSVKGSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK
60 70 80 90 100
RSNVQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYSYEAK
110 120 130 140 150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG STLEEDIQGD
160 170 180 190 200
TSGYLERILV CLLQGSRDDV SGFVDPGLVL QDAQALHEAG EKIMGTDEMK
210 220 230 240 250
FITILCTRSA THLMRVFEEY EKIANKCIED SIKSETHGSL EEAMLTVVKC
260 270 280 290 300
TRNVHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKGQFKKMYG
310 320
KTLSSMIMAD TSGYYKTALL NLVGTDL
Length:327
Mass (Da):36,724
Last modified:July 27, 2011 - v2
Checksum:i56DB9CFAFA8C2B21
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q921D0Q921D0_MOUSE
Annexin
Anxa8
301Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → T in CAA05364 (PubMed:9434938).Curated1
Sequence conflicti210A → L in CAA05364 (PubMed:9434938).Curated1
Sequence conflicti225N → D in CAA05364 (PubMed:9434938).Curated1
Sequence conflicti232I → F in CAA05364 (PubMed:9434938).Curated1
Sequence conflicti296K → R in CAA05364 (PubMed:9434938).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002390 mRNA Translation: CAA05364.1
BC030407 mRNA Translation: AAH30407.1
CCDSiCCDS26932.1
RefSeqiNP_001268774.1, NM_001281845.1
NP_038501.2, NM_013473.4
UniGeneiMm.3267

Genome annotation databases

EnsembliENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950
GeneIDi11752
KEGGimmu:11752
UCSCiuc007taj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002390 mRNA Translation: CAA05364.1
BC030407 mRNA Translation: AAH30407.1
CCDSiCCDS26932.1
RefSeqiNP_001268774.1, NM_001281845.1
NP_038501.2, NM_013473.4
UniGeneiMm.3267

3D structure databases

ProteinModelPortaliO35640
SMRiO35640
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO35640
PhosphoSitePlusiO35640

Proteomic databases

MaxQBiO35640
PaxDbiO35640
PeptideAtlasiO35640
PRIDEiO35640

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950
GeneIDi11752
KEGGimmu:11752
UCSCiuc007taj.2 mouse

Organism-specific databases

CTDi653145
MGIiMGI:1201374 Anxa8

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiO35640
KOiK17096
OMAiKGSPHFN
OrthoDBiEOG091G0H6H
TreeFamiTF105452

Miscellaneous databases

PROiPR:O35640
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021950 Expressed in 161 organ(s), highest expression level in ear
CleanExiMM_ANXA8
ExpressionAtlasiO35640 baseline and differential
GenevisibleiO35640 MM

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR009115 ANX8
PANTHERiPTHR10502:SF133 PTHR10502:SF133, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01808 ANNEXINVIII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANXA8_MOUSE
AccessioniPrimary (citable) accession number: O35640
Secondary accession number(s): Q8K2N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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