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Protein

Annexin A3

Gene

Anxa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of phospholipase A2, also possesses anti-coagulant properties.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPhospholipase A2 inhibitor
LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A3
Alternative name(s):
35-alpha calcimedin
Annexin III
Annexin-3
Lipocortin III
Placental anticoagulant protein III
Short name:
PAP-III
Gene namesi
Name:Anxa3
Synonyms:Anx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1201378 Anxa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674782 – 323Annexin A3Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei177N6-acetyllysineCombined sources1
Modified residuei267PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35639
MaxQBiO35639
PaxDbiO35639
PeptideAtlasiO35639
PRIDEiO35639

2D gel databases

COMPLUYEAST-2DPAGEiO35639
REPRODUCTION-2DPAGEiO35639

PTM databases

iPTMnetiO35639
PhosphoSitePlusiO35639

Expressioni

Gene expression databases

BgeeiENSMUSG00000029484 Expressed in 263 organ(s), highest expression level in right lung lobe
CleanExiMM_ANXA3
ExpressionAtlasiO35639 baseline and differential
GenevisibleiO35639 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198109, 2 interactors
IntActiO35639, 3 interactors
MINTiO35639
STRINGi10090.ENSMUSP00000031447

Structurei

3D structure databases

ProteinModelPortaliO35639
SMRiO35639
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 87Annexin 1Add BLAST61
Repeati99 – 159Annexin 2Add BLAST61
Repeati183 – 243Annexin 3Add BLAST61
Repeati258 – 318Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiO35639
KOiK17089
OMAiLWVGHRG
OrthoDBiEOG091G0H6H
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002390 ANX3
PANTHERiPTHR10502:SF25 PTHR10502:SF25, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00199 ANNEXINIII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O35639-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASIWVGPRG TIKDYPGFSP SVDAEAIRKA IRGLGTDEKT LINILTERSN
60 70 80 90 100
AQRQLIVKQY QAAYEQELKD DLKGDLSGHF EHVMVALVTA PALFDAKQLK
110 120 130 140 150
KSMKGTGTDE DALIEILTTR SSRQMKEISQ AYYTVYKKSL GDDISSETSG
160 170 180 190 200
DFRKALLTLA DGRRDESLKV DEHLAKKDAQ ILYNAGENKW GTDEDKFTEV
210 220 230 240 250
LCLRSFPQLK LTFDEYRNIS QKDIEDSIKG ELSGHFEDLL LAIVHCARNT
260 270 280 290 300
PAFLAERLHQ ALKGAGTDEF TLNRIMVSRS EIDLLDIRHE FKKHYGYSLY
310 320
SAIQSDTSGD YRTVLLKICG EDD
Length:323
Mass (Da):36,384
Last modified:July 27, 2011 - v4
Checksum:iE869F181A8AC60B9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TET3Q3TET3_MOUSE
Annexin
Anxa3
180Annotation score:
A0A0G2JDV9A0A0G2JDV9_MOUSE
Annexin
Anxa3
78Annotation score:
A0A0G2JGL7A0A0G2JGL7_MOUSE
Annexin A3
Anxa3
84Annotation score:
A0A0G2JFB3A0A0G2JFB3_MOUSE
Annexin A3
Anxa3
32Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97 – 98KQ → NE in CAA04887 (PubMed:9511742).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001633 mRNA Translation: CAA04887.1
AK150922 mRNA Translation: BAE29960.1
AK150951 mRNA Translation: BAE29984.1
AK151771 mRNA Translation: BAE30677.1
AK152863 mRNA Translation: BAE31554.1
AK168396 mRNA Translation: BAE40320.1
AK168507 mRNA Translation: BAE40390.1
BC090634 mRNA Translation: AAH90634.1
CCDSiCCDS51568.1
RefSeqiNP_038498.2, NM_013470.2
UniGeneiMm.7214

Genome annotation databases

EnsembliENSMUST00000031447; ENSMUSP00000031447; ENSMUSG00000029484
GeneIDi11745
KEGGimmu:11745
UCSCiuc008yfm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001633 mRNA Translation: CAA04887.1
AK150922 mRNA Translation: BAE29960.1
AK150951 mRNA Translation: BAE29984.1
AK151771 mRNA Translation: BAE30677.1
AK152863 mRNA Translation: BAE31554.1
AK168396 mRNA Translation: BAE40320.1
AK168507 mRNA Translation: BAE40390.1
BC090634 mRNA Translation: AAH90634.1
CCDSiCCDS51568.1
RefSeqiNP_038498.2, NM_013470.2
UniGeneiMm.7214

3D structure databases

ProteinModelPortaliO35639
SMRiO35639
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198109, 2 interactors
IntActiO35639, 3 interactors
MINTiO35639
STRINGi10090.ENSMUSP00000031447

PTM databases

iPTMnetiO35639
PhosphoSitePlusiO35639

2D gel databases

COMPLUYEAST-2DPAGEiO35639
REPRODUCTION-2DPAGEiO35639

Proteomic databases

EPDiO35639
MaxQBiO35639
PaxDbiO35639
PeptideAtlasiO35639
PRIDEiO35639

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031447; ENSMUSP00000031447; ENSMUSG00000029484
GeneIDi11745
KEGGimmu:11745
UCSCiuc008yfm.2 mouse

Organism-specific databases

CTDi306
MGIiMGI:1201378 Anxa3

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiO35639
KOiK17089
OMAiLWVGHRG
OrthoDBiEOG091G0H6H
TreeFamiTF105452

Miscellaneous databases

PROiPR:O35639
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029484 Expressed in 263 organ(s), highest expression level in right lung lobe
CleanExiMM_ANXA3
ExpressionAtlasiO35639 baseline and differential
GenevisibleiO35639 MM

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002390 ANX3
PANTHERiPTHR10502:SF25 PTHR10502:SF25, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00199 ANNEXINIII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANXA3_MOUSE
AccessioniPrimary (citable) accession number: O35639
Secondary accession number(s): Q3UBI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 138 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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