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Protein

Cohesin subunit SA-2

Gene

Stag2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Meiosis, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2467813 Separation of Sister Chromatids
R-MMU-2468052 Establishment of Sister Chromatid Cohesion
R-MMU-2470946 Cohesin Loading onto Chromatin
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Cohesin subunit SA-2
Alternative name(s):
SCC3 homolog 2
Stromal antigen 2
Gene namesi
Name:Stag2
Synonyms:Sa2, Sap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1098583 Stag2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201861 – 1231Cohesin subunit SA-2Add BLAST1231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei607N6-acetyllysineBy similarity1
Modified residuei1058PhosphoserineCombined sources1
Modified residuei1061PhosphoserineCombined sources1
Modified residuei1064PhosphoserineCombined sources1
Modified residuei1065PhosphoserineCombined sources1
Modified residuei1112PhosphothreonineBy similarity1
Modified residuei1177PhosphoserineBy similarity1
Modified residuei1178PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35638
MaxQBiO35638
PaxDbiO35638
PeptideAtlasiO35638
PRIDEiO35638

PTM databases

iPTMnetiO35638
PhosphoSitePlusiO35638

Expressioni

Gene expression databases

BgeeiENSMUSG00000025862 Expressed in 297 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_STAG2
ExpressionAtlasiO35638 baseline and differential
GenevisibleiO35638 MM

Interactioni

Subunit structurei

Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi203518, 17 interactors
DIPiDIP-56691N
IntActiO35638, 18 interactors
MINTiO35638
STRINGi10090.ENSMUSP00000063250

Structurei

3D structure databases

ProteinModelPortaliO35638
SMRiO35638
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini293 – 378SCDPROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1096 – 1101Poly-Ser6

Sequence similaritiesi

Belongs to the SCC3 family.Curated

Phylogenomic databases

eggNOGiKOG2011 Eukaryota
COG5537 LUCA
GeneTreeiENSGT00390000014094
HOGENOMiHOG000231375
HOVERGENiHBG057636
InParanoidiO35638
KOiK06671
OMAiICDLLII
TreeFamiTF314604

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039662 Cohesin_Scc3/SA
IPR020839 SCD
IPR013721 STAG
PANTHERiPTHR11199 PTHR11199, 1 hit
PfamiView protein in Pfam
PF08514 STAG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51425 SCD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O35638-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIAAPEIPTD FNLLQESETH FSSDTDFEDI EGKNQKQGKG KTCKKGKKGP
60 70 80 90 100
AEKGKSGNGG GKPPSGSNRM NGHHQQNGVE NMMLFEVVKM GKSAMQSVVD
110 120 130 140 150
DWIESYKHDR DIALLDLINF FIQCSGCKGV VTAEMFRHMQ NSEIIRKMTE
160 170 180 190 200
EFDEDSGDYP LTMAGPQWKK FKSSFCEFIG VLVRQCQYSI IYDEYMMDTV
210 220 230 240 250
ISLLTGLSDS QVRAFRHTST LAAMKLMTAL VNVALNLSIN MDNTQRQYEA
260 270 280 290 300
ERNKMIGKRA NERLELLLQK RKELQENQDE IENMMNAIFK GVFVHRYRDA
310 320 330 340 350
IAEIRAICIE EIGIWMKMYS DAFLNDSYLK YVGWTMHDKQ GEVRLKCLTA
360 370 380 390 400
LQGLYYNKEL NSKLELFTSR FKDRIVSMTL DKEYDVAVQA IKLLTLVLQS
410 420 430 440 450
SEEVLTAEDC ENVYHLVYSA HRPVAVAAGE FLYKKLFSRR DPEEDGLMKR
460 470 480 490 500
RGRQGPNANL VKTLVFFFLE SELHEHAAYL VDSMWDCATE LLKDWECMNS
510 520 530 540 550
LLLEEPLSGE EALTDRQESA LIEIMLCTIR QAAECHPPVG RGTGKRVLTA
560 570 580 590 600
KEKKTQLDDR TRITELFAVA LPQLLAKYSV DAEKVTNLLQ LPQYFDLEIY
610 620 630 640 650
TTGRLEKHLD ALLRQIRNIV EKHTDTDVLE ACSKTYHALC NEEFTIFNRV
660 670 680 690 700
DISRSQLIDE LADKFNRLLE DFLQEGEEPD EDDAYQVLST LKRITAFHNA
710 720 730 740 750
HDLSKWDLFA CNYKLLKTGI ENGDMPEQIV IHALQCAHYV ILWQLAKITE
760 770 780 790 800
STSTKEDLLR LKKQMRVFCQ ICQHYLTNVN TTVKEQAFTI LCDILMIFSH
810 820 830 840 850
QIMSGGRDML EPLVYTPDSS LQSELLSFIL DHVFIEQDDD SNSADGQQED
860 870 880 890 900
EASKIEALHK RRNLLAAFCK LIVYTVVEMN TAADIFKQYM KYYNDYGDII
910 920 930 940 950
KETMSKTRQI DKIQCAKTLI LSLQQLFNEM IQENGYNFDR SSSTFSGIKE
960 970 980 990 1000
LARRFALTFG LDQLKTREAI AMLHKDGIEF AFKEPNPQGE SHPPLNLAFL
1010 1020 1030 1040 1050
DILSEFSSKL LRQDKRTVYV YLEKFMTFQM SLRREDVWLP LMSYRNSLLA
1060 1070 1080 1090 1100
GGDDDTMSVI SGMSSRGSTV RSKKSKPSTG KRKVVEGMQL ALPEESSSSD
1110 1120 1130 1140 1150
SMWLSREQTL HTPVMMQTPQ LTSTIMREPK RLRPEDSFMS VYPMQAEHHQ
1160 1170 1180 1190 1200
TPLDYNRRGT SLMEDDEEPI VEDVMMSSEG RIEDLNEGMD FDTMDIDLPP
1210 1220 1230
SKNRRERTEL KPDFFDPASI MDESVLGVSM F
Length:1,231
Mass (Da):141,281
Last modified:July 27, 2011 - v3
Checksum:iAD7ECB66E18C080B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AFF6A2AFF6_MOUSE
Cohesin subunit SA-2
Stag2
1,268Annotation score:
A2AFF3A2AFF3_MOUSE
Cohesin subunit SA-2
Stag2
40Annotation score:
B7ZCD2B7ZCD2_MOUSE
Cohesin subunit SA-2
Stag2
41Annotation score:
A0A1B0GXA7A0A1B0GXA7_MOUSE
Cohesin subunit SA-2
Stag2
145Annotation score:

Sequence cautioni

The sequence BC066041 differs from that shown. Reason: Frameshift at position 54.Curated
The sequence BC066041 differs from that shown. Reason: Frameshift at position 53.Curated
The sequence CAA05638 differs from that shown. Reason: Frameshift at position 22.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8P → Q in CAA05638 (Ref. 1) Curated1
Sequence conflicti34N → I in CAA05638 (Ref. 1) Curated1
Sequence conflicti299D → Y in CAA05638 (Ref. 1) Curated1
Sequence conflicti607 – 608KH → ND in CAA05638 (Ref. 1) Curated2
Sequence conflicti881T → S in CAA05638 (Ref. 1) Curated1
Sequence conflicti951L → F in CAA05638 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002636 mRNA Translation: CAA05638.1 Frameshift.
AL672089 Genomic DNA No translation available.
BC066041 mRNA No translation available.
CCDSiCCDS40952.1
PIRiT30194
RefSeqiNP_001071180.1, NM_001077712.2
NP_067440.3, NM_021465.4
XP_011249291.1, XM_011250989.2
XP_017173935.1, XM_017318446.1
UniGeneiMm.290422

Genome annotation databases

EnsembliENSMUST00000069619; ENSMUSP00000063250; ENSMUSG00000025862
ENSMUST00000115072; ENSMUSP00000110724; ENSMUSG00000025862
GeneIDi20843
KEGGimmu:20843
UCSCiuc009tax.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002636 mRNA Translation: CAA05638.1 Frameshift.
AL672089 Genomic DNA No translation available.
BC066041 mRNA No translation available.
CCDSiCCDS40952.1
PIRiT30194
RefSeqiNP_001071180.1, NM_001077712.2
NP_067440.3, NM_021465.4
XP_011249291.1, XM_011250989.2
XP_017173935.1, XM_017318446.1
UniGeneiMm.290422

3D structure databases

ProteinModelPortaliO35638
SMRiO35638
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203518, 17 interactors
DIPiDIP-56691N
IntActiO35638, 18 interactors
MINTiO35638
STRINGi10090.ENSMUSP00000063250

PTM databases

iPTMnetiO35638
PhosphoSitePlusiO35638

Proteomic databases

EPDiO35638
MaxQBiO35638
PaxDbiO35638
PeptideAtlasiO35638
PRIDEiO35638

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069619; ENSMUSP00000063250; ENSMUSG00000025862
ENSMUST00000115072; ENSMUSP00000110724; ENSMUSG00000025862
GeneIDi20843
KEGGimmu:20843
UCSCiuc009tax.2 mouse

Organism-specific databases

CTDi10735
MGIiMGI:1098583 Stag2

Phylogenomic databases

eggNOGiKOG2011 Eukaryota
COG5537 LUCA
GeneTreeiENSGT00390000014094
HOGENOMiHOG000231375
HOVERGENiHBG057636
InParanoidiO35638
KOiK06671
OMAiICDLLII
TreeFamiTF314604

Enzyme and pathway databases

ReactomeiR-MMU-2467813 Separation of Sister Chromatids
R-MMU-2468052 Establishment of Sister Chromatid Cohesion
R-MMU-2470946 Cohesin Loading onto Chromatin
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

PROiPR:O35638
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025862 Expressed in 297 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_STAG2
ExpressionAtlasiO35638 baseline and differential
GenevisibleiO35638 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039662 Cohesin_Scc3/SA
IPR020839 SCD
IPR013721 STAG
PANTHERiPTHR11199 PTHR11199, 1 hit
PfamiView protein in Pfam
PF08514 STAG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51425 SCD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTAG2_MOUSE
AccessioniPrimary (citable) accession number: O35638
Secondary accession number(s): A2AFF5, Q6NZN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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