Nr1i3

Functionⁱ

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	171	Important for TCPOBOP recognition	1
Siteⁱ	175	Important for TCPOBOP recognition	1
Siteⁱ	216	Important for TCPOBOP recognition	1
Siteⁱ	227	Important for TCPOBOP recognition	1
Siteⁱ	244	Important for TCPOBOP recognition	1
Siteⁱ	336	Important for TCPOBOP recognition	1

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	18 – 93	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	21 – 41	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	57 – 81	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 11891224
DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear receptor transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hormone receptor activity Source: InterPro
thyroid hormone receptor activity Source: InterPro
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
multicellular organism development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 11891224
positive regulation of transcription by RNA polymerase II Source: MGI
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 11891224

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor subfamily 1 group I member 3 Alternative name(s): Constitutive androstane receptor Short name: CAR Orphan nuclear receptor MB67
Gene namesⁱ	Name:Nr1i3 Synonyms:Car
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1346307 Nr1i3

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	171	F → W: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP. 1 Publication	1
Mutagenesisⁱ	175	N → F: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP. 1 Publication	1
Mutagenesisⁱ	216	L → F: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP. 1 Publication	1
Mutagenesisⁱ	227	F → W: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP. 1 Publication	1
Mutagenesisⁱ	234	Y → A: No effect on binding of coactivator NCOA2 in the presence of TCPOBOP. 1 Publication	1
Mutagenesisⁱ	244	F → A: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP. 1 Publication	1
Mutagenesisⁱ	336	Y → A: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP. 1 Publication	1
Mutagenesisⁱ	346	L → F: Dramatic increase in binding NCOA2. Little effect on binding of coactivator NCOA2 in the presence of TCPOBOP. 1 Publication	1

Chemistry databases

ChEMBLⁱ	CHEMBL3069
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	607

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053554	1 – 358	Nuclear receptor subfamily 1 group I member 3Add BLAST		358

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	48	Phosphothreonine; by PKCBy similarity		1

Post-translational modificationⁱ

Phosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	O35627
PRIDEⁱ	O35627

PTM databases

iPTMnetⁱ	O35627
PhosphoSitePlusⁱ	O35627

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in liver.

Gene expression databases

Bgeeⁱ	ENSMUSG00000005677 Expressed in 64 organ(s), highest expression level in cardiac ventricle
CleanExⁱ	MM_NR1I3
ExpressionAtlasⁱ	O35627 baseline and differential
Genevisibleⁱ	O35627 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90.4 Publications

GO - Molecular functionⁱ

transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198489, 13 interactors
STRINGⁱ	10090.ENSMUSP00000005820

Chemistry databases

BindingDBⁱ

O35627

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	118 – 134	Combined sources	17
Turnⁱ	135 – 137	Combined sources	3
Helixⁱ	138 – 144	Combined sources	7
Helixⁱ	149 – 152	Combined sources	4
Beta strandⁱ	160 – 162	Combined sources	3
Helixⁱ	164 – 187	Combined sources	24
Helixⁱ	190 – 193	Combined sources	4
Helixⁱ	197 – 216	Combined sources	20
Helixⁱ	217 – 219	Combined sources	3
Turnⁱ	222 – 225	Combined sources	4
Beta strandⁱ	226 – 229	Combined sources	4
Beta strandⁱ	232 – 234	Combined sources	3
Helixⁱ	236 – 241	Combined sources	6
Helixⁱ	246 – 260	Combined sources	15
Helixⁱ	266 – 277	Combined sources	12
Helixⁱ	288 – 308	Combined sources	21
Turnⁱ	309 – 312	Combined sources	4
Helixⁱ	318 – 335	Combined sources	18
Helixⁱ	337 – 343	Combined sources	7
Helixⁱ	345 – 349	Combined sources	5
Helixⁱ	351 – 357	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	O35627
SMRⁱ	O35627
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O35627

EvolutionaryTraceⁱ

O35627

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	119 – 358	NR LBDPROSITE-ProRule annotationAdd BLAST		240

Domainⁱ

Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	21 – 41	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	57 – 81	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136372
HOGENOMⁱ	HOG000220844
HOVERGENⁱ	HBG108655
InParanoidⁱ	O35627
KEGG Orthology (KO) More...KOⁱ	K08541
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DMU
TreeFamⁱ	TF316304

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001728 ThyrH_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER PR00546 THYROIDHORMR
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform CAR1 (identifier: O35627-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAMLTLETM ASEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS 
        60         70         80         90        100
KTIGPICPFA GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR 
       110        120        130        140        150
RARQAQRRAE KASLQLNQQQ KELVQILLGA HTRHVGPMFD QFVQFKPPAY 
       160        170        180        190        200
LFMHHRPFQP RGPVLPLLTH FADINTFMVQ QIIKFTKDLP LFRSLTMEDQ 
       210        220        230        240        250
ISLLKGAAVE ILHISLNTTF CLQTENFFCG PLCYKMEDAV HAGFQYEFLE 
       260        270        280        290        300
SILHFHKNLK GLHLQEPEYV LMAATALFSP DRPGVTQREE IDQLQEEMAL 
       310        320        330        340        350
ILNNHIMEQQ SRLQSRFLYA KLMGLLADLR SINNAYSYEL QRLEELSAMT 

PLLGEICS

Length:358

Mass (Da):40,913

Last modified:July 27, 2011 - v2

Checksum:ⁱA11C92B1EC2C06A7

GO

Isoform CAR2 (identifier: O35627-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
281-286: DRPGVT → GFCMQS
287-358: Missing.

« Hide

        10         20         30         40         50
MTAMLTLETM ASEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS 
        60         70         80         90        100
KTIGPICPFA GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR 
       110        120        130        140        150
RARQAQRRAE KASLQLNQQQ KELVQILLGA HTRHVGPMFD QFVQFKPPAY 
       160        170        180        190        200
LFMHHRPFQP RGPVLPLLTH FADINTFMVQ QIIKFTKDLP LFRSLTMEDQ 
       210        220        230        240        250
ISLLKGAAVE ILHISLNTTF CLQTENFFCG PLCYKMEDAV HAGFQYEFLE 
       260        270        280 
SILHFHKNLK GLHLQEPEYV LMAATALFSP GFCMQS

Note: Does not seem to act as a transactivator. Lacks the C-terminal portion of the ligand binding/dimerization domain.

Show »

Length:286

Mass (Da):32,544

Checksum:ⁱDAEF17A3369F529E

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5FW96	Q5FW96_MOUSE	Nuclear receptor subfamily 1 group ... Nuclear receptor subfamily 1 group I member 3 (Nuclear receptor subfamily 1, group I, member 3)	Nr1i3	357	Annotation score:
Q3UEP1	Q3UEP1_MOUSE	Nuclear receptor subfamily 1 group ... Nuclear receptor subfamily 1 group I member 3	Nr1i3	221	Annotation score:
M0QWI8	M0QWI8_MOUSE	Nuclear receptor subfamily 1 group ... Nuclear receptor subfamily 1 group I member 3	Nr1i3	95	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	138	M → L in AAC53349 (PubMed:9295294).Curated		1
Sequence conflictⁱ	138	M → L in AAC53350 (PubMed:9295294).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003671	281 – 286	DRPGVT → GFCMQS in isoform CAR2. 1 Publication		6
Alternative sequenceⁱVSP_003672	287 – 358	Missing in isoform CAR2. 1 PublicationAdd BLAST		72

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF009327 mRNA Translation: AAC53349.1 AF009328 mRNA Translation: AAC53350.1 AK133515 mRNA Translation: BAE21697.1 CH466520 Genomic DNA Translation: EDL39126.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15480.1 [O35627-1] CCDS56654.1 [O35627-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001229991.1, NM_001243062.1 [O35627-2] NP_001229992.1, NM_001243063.1 NP_033933.2, NM_009803.5 [O35627-1]
UniGeneⁱ	Mm.486506

Genome annotation databases

Ensemblⁱ	ENSMUST00000005820; ENSMUSP00000005820; ENSMUSG00000005677 [O35627-1] ENSMUST00000075469; ENSMUSP00000074915; ENSMUSG00000005677 [O35627-2]
GeneIDⁱ	12355
KEGGⁱ	mmu:12355
UCSC genome browser More...UCSCⁱ	uc007dnf.2 mouse [O35627-1] uc007dng.2 mouse [O35627-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35627	Nuclear receptor subfamily 1 group I member 3		MOUSE		221	UniRef100_O35627

Protein	Similar proteins		Species	Score	Length	Source
O35627	Nuclear receptor subfamily 1 group I member 3		RAT		358	UniRef90_O35627
Nuclear receptor subfamily 1 group I member 3		MOUSE		221
UPI000A308380		MUSPA		367
UPI000A314DB0		MUSCR		358
Constitutive androstane receptor splicing variant 2		RAT		316
+14

Protein	Similar proteins		Species	Score	Length	Source
O35627	Nuclear receptor subfamily 1 group I member 3	)	HUMAN		352	UniRef50_Q14994
Nuclear receptor subfamily 1 group I member 3		PANTR		348
Nuclear receptor subfamily 1 group I member 3		RAT		358
Nuclear receptor subfamily 1 group I member 3		PUSSI		348
Nuclear receptor subfamily 1 group I member 3		CALUR		348
+196
O35627-2	Isoform 13 of Nuclear receptor subfamily 1 group I member 3		HUMAN		340	UniRef50_Q14994-13
NR1I3 isoform 12		PONAB		340
NR1I3 isoform 11		PANTR		340
Uncharacterized protein		AOTNA		338
Uncharacterized protein		COLAP		315
+113

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF009327 mRNA Translation: AAC53349.1 AF009328 mRNA Translation: AAC53350.1 AK133515 mRNA Translation: BAE21697.1 CH466520 Genomic DNA Translation: EDL39126.1
CCDSⁱ	CCDS15480.1 [O35627-1] CCDS56654.1 [O35627-2]
RefSeqⁱ	NP_001229991.1, NM_001243062.1 [O35627-2] NP_001229992.1, NM_001243063.1 NP_033933.2, NM_009803.5 [O35627-1]
UniGeneⁱ	Mm.486506

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1XLS	X-ray	2.96	E/F/G/H	117-358	[»]
	1XNX	X-ray	2.90	A/B	109-358	[»]
ProteinModelPortalⁱ	O35627
SMRⁱ	O35627
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198489, 13 interactors
STRINGⁱ	10090.ENSMUSP00000005820

Chemistry databases

BindingDBⁱ	O35627
ChEMBLⁱ	CHEMBL3069
GuidetoPHARMACOLOGYⁱ	607

PTM databases

iPTMnetⁱ	O35627
PhosphoSitePlusⁱ	O35627

Proteomic databases

PaxDbⁱ	O35627
PRIDEⁱ	O35627

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000005820; ENSMUSP00000005820; ENSMUSG00000005677 [O35627-1] ENSMUST00000075469; ENSMUSP00000074915; ENSMUSG00000005677 [O35627-2]
GeneIDⁱ	12355
KEGGⁱ	mmu:12355
UCSCⁱ	uc007dnf.2 mouse [O35627-1] uc007dng.2 mouse [O35627-2]

Organism-specific databases

CTDⁱ	9970
MGIⁱ	MGI:1346307 Nr1i3

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00870000136372
HOGENOMⁱ	HOG000220844
HOVERGENⁱ	HBG108655
InParanoidⁱ	O35627
KOⁱ	K08541
OrthoDBⁱ	EOG091G0DMU
TreeFamⁱ	TF316304

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSⁱ	Nr1i3 mouse
EvolutionaryTraceⁱ	O35627
Protein Ontology More...PROⁱ	PR:O35627
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005677 Expressed in 64 organ(s), highest expression level in cardiac ventricle
CleanExⁱ	MM_NR1I3
ExpressionAtlasⁱ	O35627 baseline and differential
Genevisibleⁱ	O35627 MM

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001728 ThyrH_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER PR00546 THYROIDHORMR
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NR1I3_MOUSE
Accessionⁱ	O35627Primary (citable) accession number: O35627 Secondary accession number(s): O35628, Q3V008
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O35627 (NR1I3_MOUSE)

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Nuclear receptor subfamily 1 group I member 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ