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Protein

BET1 homolog

Gene

Bet1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport

Names & Taxonomyi

Protein namesi
Recommended name:
BET1 homolog
Short name:
mBET1
Alternative name(s):
Golgi vesicular membrane-trafficking protein p18
Gene namesi
Name:Bet1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1343104 Bet1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 94CytoplasmicSequence analysisAdd BLAST94
Transmembranei95 – 115Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini116 – 118VesicularSequence analysis3

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002068851 – 118BET1 homologAdd BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35623
MaxQBiO35623
PaxDbiO35623
PeptideAtlasiO35623
PRIDEiO35623
TopDownProteomicsiO35623

PTM databases

iPTMnetiO35623
PhosphoSitePlusiO35623
SwissPalmiO35623

Expressioni

Gene expression databases

BgeeiENSMUSG00000032757 Expressed in 275 organ(s), highest expression level in decidua
GenevisibleiO35623 MM

Interactioni

Subunit structurei

Interacts with STX17.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198337, 1 interactor
STRINGi10090.ENSMUSP00000044877

Structurei

3D structure databases

ProteinModelPortaliO35623
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 88t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the BET1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3385 Eukaryota
ENOG4111W10 LUCA
GeneTreeiENSGT00570000079186
HOGENOMiHOG000290697
HOVERGENiHBG029661
InParanoidiO35623
KOiK08504
OMAiKLLCYML
OrthoDBiEOG091G16Y8
PhylomeDBiO35623
TreeFamiTF323307

Family and domain databases

CDDicd15853 SNARE_Bet1, 1 hit
InterProiView protein in InterPro
IPR039897 BET1
IPR039899 BET1_SNARE
IPR000727 T_SNARE_dom
PANTHERiPTHR12791 PTHR12791, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

O35623-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRAGLGDGA PPGSYGNYGY ANTGYNACEE ENDRLTESLR SKVTAIKSLS
60 70 80 90 100
IEIGHEVKNQ NKLLAEMDSQ FDSTTGFLGK TMGRLKILSR GSQTKLLCYM
110
MLFSLFVFFV IYWIIKLR
Length:118
Mass (Da):13,274
Last modified:January 1, 1998 - v1
Checksum:iCB81C325119BA152
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007552 mRNA Translation: AAB62942.1
BC005572 mRNA Translation: AAH05572.1
CCDSiCCDS19895.1
RefSeqiNP_033878.1, NM_009748.2
UniGeneiMm.286457

Genome annotation databases

EnsembliENSMUST00000049166; ENSMUSP00000044877; ENSMUSG00000032757
GeneIDi12068
KEGGimmu:12068
UCSCiuc009avk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007552 mRNA Translation: AAB62942.1
BC005572 mRNA Translation: AAH05572.1
CCDSiCCDS19895.1
RefSeqiNP_033878.1, NM_009748.2
UniGeneiMm.286457

3D structure databases

ProteinModelPortaliO35623
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198337, 1 interactor
STRINGi10090.ENSMUSP00000044877

PTM databases

iPTMnetiO35623
PhosphoSitePlusiO35623
SwissPalmiO35623

Proteomic databases

EPDiO35623
MaxQBiO35623
PaxDbiO35623
PeptideAtlasiO35623
PRIDEiO35623
TopDownProteomicsiO35623

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049166; ENSMUSP00000044877; ENSMUSG00000032757
GeneIDi12068
KEGGimmu:12068
UCSCiuc009avk.1 mouse

Organism-specific databases

CTDi10282
MGIiMGI:1343104 Bet1

Phylogenomic databases

eggNOGiKOG3385 Eukaryota
ENOG4111W10 LUCA
GeneTreeiENSGT00570000079186
HOGENOMiHOG000290697
HOVERGENiHBG029661
InParanoidiO35623
KOiK08504
OMAiKLLCYML
OrthoDBiEOG091G16Y8
PhylomeDBiO35623
TreeFamiTF323307

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRSiBet1 mouse
PROiPR:O35623
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032757 Expressed in 275 organ(s), highest expression level in decidua
GenevisibleiO35623 MM

Family and domain databases

CDDicd15853 SNARE_Bet1, 1 hit
InterProiView protein in InterPro
IPR039897 BET1
IPR039899 BET1_SNARE
IPR000727 T_SNARE_dom
PANTHERiPTHR12791 PTHR12791, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBET1_MOUSE
AccessioniPrimary (citable) accession number: O35623
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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