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Protein

Fibroblast growth factor 15

Gene

Fgf15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1307965 betaKlotho-mediated ligand binding
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 15
Short name:
FGF-15
Gene namesi
Name:Fgf15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1096383 Fgf15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000898426 – 218Fibroblast growth factor 15Add BLAST193

Proteomic databases

PaxDbiO35622
PRIDEiO35622

PTM databases

PhosphoSitePlusiO35622

Expressioni

Tissue specificityi

Expressed in the developing brain.

Gene expression databases

BgeeiENSMUSG00000031073 Expressed in 108 organ(s), highest expression level in optic fissure
CleanExiMM_FGF15
ExpressionAtlasiO35622 baseline and differential
GenevisibleiO35622 MM

Interactioni

Subunit structurei

Interacts with MALRD1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033389

Structurei

3D structure databases

ProteinModelPortaliO35622
SMRiO35622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112572
HOVERGENiHBG051611
InParanoidiO35622
KOiK22603
OMAiYFLPMLP
OrthoDBiEOG091G0NAY
PhylomeDBiO35622
TreeFamiTF335872

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR035444 FGF15/19/21
IPR028303 FGF15/FGF19
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF74 PTHR11486:SF74, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PIRSFiPIRSF037961 FGF-19_FGF-21, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35622-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARKWNGRAV ARALVLATLW LAVSGRPLAQ QSQSVSDEDP LFLYGWGKIT
60 70 80 90 100
RLQYLYSAGP YVSNCFLRIR SDGSVDCEED QNERNLLEFR AVALKTIAIK
110 120 130 140 150
DVSSVRYLCM SADGKIYGLI RYSEEDCTFR EEMDCLGYNQ YRSMKHHLHI
160 170 180 190 200
IFIQAKPREQ LQDQKPSNFI PVFHRSFFET GDQLRSKMFS LPLESDSMDP
210
FRMVEDVDHL VKSPSFQK
Length:218
Mass (Da):25,236
Last modified:January 1, 1998 - v1
Checksum:iA96B0D771FE125A5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LIL5A0A140LIL5_MOUSE
Fibroblast growth factor 15
Fgf15
161Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007268 mRNA Translation: AAB63197.1
AK017829 mRNA Translation: BAB30961.1
BC021328 mRNA Translation: AAH21328.1
CCDSiCCDS22053.1
RefSeqiNP_032029.1, NM_008003.2
UniGeneiMm.3904

Genome annotation databases

EnsembliENSMUST00000033389; ENSMUSP00000033389; ENSMUSG00000031073
GeneIDi14170
KEGGimmu:14170
UCSCiuc009kqr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007268 mRNA Translation: AAB63197.1
AK017829 mRNA Translation: BAB30961.1
BC021328 mRNA Translation: AAH21328.1
CCDSiCCDS22053.1
RefSeqiNP_032029.1, NM_008003.2
UniGeneiMm.3904

3D structure databases

ProteinModelPortaliO35622
SMRiO35622
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033389

PTM databases

PhosphoSitePlusiO35622

Proteomic databases

PaxDbiO35622
PRIDEiO35622

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033389; ENSMUSP00000033389; ENSMUSG00000031073
GeneIDi14170
KEGGimmu:14170
UCSCiuc009kqr.1 mouse

Organism-specific databases

CTDi14170
MGIiMGI:1096383 Fgf15

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112572
HOVERGENiHBG051611
InParanoidiO35622
KOiK22603
OMAiYFLPMLP
OrthoDBiEOG091G0NAY
PhylomeDBiO35622
TreeFamiTF335872

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1307965 betaKlotho-mediated ligand binding
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

PROiPR:O35622
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031073 Expressed in 108 organ(s), highest expression level in optic fissure
CleanExiMM_FGF15
ExpressionAtlasiO35622 baseline and differential
GenevisibleiO35622 MM

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR035444 FGF15/19/21
IPR028303 FGF15/FGF19
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF74 PTHR11486:SF74, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PIRSFiPIRSF037961 FGF-19_FGF-21, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF15_MOUSE
AccessioniPrimary (citable) accession number: O35622
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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