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Protein

Zinc finger protein ZFPM1

Gene

Zfpm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri249 – 282CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri303 – 327C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri333 – 355C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 384C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri584 – 617CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri690 – 723CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri830 – 863CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri868 – 891C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri957 – 990CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein ZFPM1
Alternative name(s):
Friend of GATA protein 1
Short name:
FOG-1
Short name:
Friend of GATA 1
Zinc finger protein multitype 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfpm1
Synonyms:Fog, Fog1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1095400 Zfpm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi254V → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi255F → A: Impairs interaction with GATA1. 1 Publication1
Mutagenesisi256P → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi258K → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi259D → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi261G → A: Slightly affects the interaction with GATA1. 1 Publication1
Mutagenesisi262I → A: Impairs interaction with GATA1. 1 Publication1
Mutagenesisi263W → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi265R → A: Slightly affects the interaction with GATA1. 1 Publication1
Mutagenesisi266S → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi267E → A: Slightly affects the interaction with GATA1. 1 Publication1
Mutagenesisi268R → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi269N → A: Impairs interaction with GATA1. 1 Publication1
Mutagenesisi271Q → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi274L → A: Slightly affects the interaction with GATA1. 1 Publication1
Mutagenesisi275L → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi276Y → A: Slightly affects the interaction with GATA1. 1 Publication1
Mutagenesisi277Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-612; A-718 and/or A-985. 1 Publication1
Mutagenesisi280S → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi281R → A: Does not affect the interaction with GATA1. 1 Publication1
Mutagenesisi334V → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi336L → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi339L → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi340S → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi343T → A: Impairs interaction with TACC3. 1 Publication1
Mutagenesisi344T → A: Abolishes interaction with TACC3. 1 Publication1
Mutagenesisi345K → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi346A → D: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi347N → A: Abolishes interaction with TACC3. 1 Publication1
Mutagenesisi349E → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi350R → A: Abolishes interaction with TACC3. 1 Publication1
Mutagenesisi352L → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi353K → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi354V → A: Abolishes interaction with TACC3. 1 Publication1
Mutagenesisi356T → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi357D → A: No effect on interaction with TACC3. 1 Publication1
Mutagenesisi612Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-718 and/or A-985. 1 Publication1
Mutagenesisi698C → A: Abolishes interaction with GATA1. 1 Publication1
Mutagenesisi706S → R: Able to partially restore the interaction with the G-205 GATA1 mutant, which is usually unable to interact with ZFPM1. 1 Publication1
Mutagenesisi718Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-985. 1 Publication1
Mutagenesisi719C → A: Abolishes interaction with GATA1. 1 Publication1
Mutagenesisi719C → H: Transforms the C2HC-type zinc finger into a C2H2-type, leading to abolition of interaction with GATA1. 1 Publication1
Mutagenesisi811 – 814PIDL → AIAA: Abolishes interaction with CTBP2. 1 Publication4
Mutagenesisi813 – 814DL → AS: Abolishes interaction with CTBP2; it however does not abolish the corepressor activity in erythropoiesis. 1 Publication2
Mutagenesisi985Y → A: Slightly affects the interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-718. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002210421 – 995Zinc finger protein ZFPM1Add BLAST995

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99PhosphoserineBy similarity1
Modified residuei143PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei397PhosphoserineBy similarity1
Modified residuei497PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei651PhosphoserineBy similarity1
Modified residuei684PhosphoserineBy similarity1
Modified residuei803PhosphoserineBy similarity1
Modified residuei822PhosphoserineCombined sources1
Modified residuei925PhosphoserineCombined sources1
Modified residuei927PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O35615

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O35615

PeptideAtlas

More...
PeptideAtlasi
O35615

PRoteomics IDEntifications database

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PRIDEi
O35615

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O35615

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O35615

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in hematopoietic tissues. Expressed in the spleen, a primary site of hematopoiesis in the adult mouse, as well as in the liver and testis, but not in the heart, brain, lung, kidney, or skeletal muscle. Among hematopoietic cell lines, it is strongly expressed in erythroid and megakaryocytic cell lines. Expressed at low level in several lymphoid and early myeloid cell lines. Not expressed in mast cell and macrophage lines. Expressed in the heart, where it colocalizes with GATA4, GATA5 and GATA6.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First expressed in two extraembryonic mesodermal derivatives, the yolk sac and the allantois in E8.5 embryos. Localized to the embryonic red blood cells within the yolk sac blood islands.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049577 Expressed in 230 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
MM_ZFPM1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O35615 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the N-terminal zinc-finger of GATA1, GATA2 and GATA3. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity in erythropoiesis. Interacts with TACC3.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204687, 11 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O35615

Database of interacting proteins

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DIPi
DIP-48414N

Protein interaction database and analysis system

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IntActi
O35615, 13 interactors

Molecular INTeraction database

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MINTi
O35615

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058037

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1995
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SRKNMR-A328-360[»]
2MPLNMR-A100-226[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O35615

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O35615

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O35615

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni343 – 354Interaction with TACC31 PublicationAdd BLAST12
Regioni811 – 817Interaction with CTBP27

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CCHC FOG-type zinc fingers 1, 2, 3 and 5 bind directly to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri249 – 282CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri303 – 327C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri333 – 355C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 384C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri584 – 617CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri690 – 723CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri830 – 863CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri868 – 891C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri957 – 990CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063823

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112626

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG101018

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O35615

KEGG Orthology (KO)

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KOi
K17441

Identification of Orthologs from Complete Genome Data

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OMAi
DVNEEHY

Database of Orthologous Groups

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OrthoDBi
76702at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O35615

TreeFam database of animal gene trees

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TreeFami
TF331342

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

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PANTHERi
PTHR12958 PTHR12958, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00096 zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O35615-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKQSNPR QIKRSLRDME AGEEAKAMDS SPKEQEAPDP EAPAIEEPPS
60 70 80 90 100
PPREDVSPPA VPAPPESPED PEDMEGQELE MRPQDEEKEE KEEEAAMASP
110 120 130 140 150
WSGPEELELA LQDGQRCVRA RLSLTEGLSW GPFYGSIQTR ALSPEREEPG
160 170 180 190 200
PAVTLMVDES CWLRMLPQVL TEEAANSEIY RKDDALWCRV TKVVPSGGLL
210 220 230 240 250
YVRLVTEPHG APRHPVQEPV EPGGLAPVHT DIQLLPQQAG MASILATAVI
260 270 280 290 300
NKDVFPCKDC GIWYRSERNL QAHLLYYCAS RQRAGSPVSA TEEKPKETYP
310 320 330 340 350
NERVCPFPQC RKSCPSASSL EIHMRSHSGE RPFVCLICLS AFTTKANCER
360 370 380 390 400
HLKVHTDTLS GVCHNCGFIS TTRDILYSHL VTNHMVCQPG SKGEIYSPGA
410 420 430 440 450
GHPAAKLPPD SLAGFQQHSL MHSPLVPADK APTPSSGLDS KAEVTNGETR
460 470 480 490 500
VPPQNGGSSE SPAAPRTIKV EAAEEPEATR ASGPGEPGPQ APSRTPSPHS
510 520 530 540 550
PNPVRVKTEL SSPTPGSSPG PGELTMAGTL FLPQYVFSPD AGTTTVPTAP
560 570 580 590 600
QASEILAKMS ELVHNRLQQG AGSSGAAGTP TGLFSGTKGA TCFECEITFN
610 620 630 640 650
NINNFYVHKR LYCSGRRAPE DPPTVRRPKA ATGPARAPAG AAAEPDPSRS
660 670 680 690 700
SPGPGPREEE ASGTTTPEAE AAGRGSEGSQ SPGSSVDDAE DDPSRTLCEA
710 720 730 740 750
CNIRFSRHET YTVHKRYYCA SRHDPPPRRP PAPTTAPGPA APALTAPPVR
760 770 780 790 800
TRRRRKLYEL PAAGAPPPAA GPAPVPVVPS PTAELPSSPR PGSASAGPAP
810 820 830 840 850
ALSPSPVPDG PIDLSKRPRR QSPDAPTALP ALADYHECTA CRVSFHSLEA
860 870 880 890 900
YLAHKKYSCP AAPLRTTALC PYCPPNGRVR GDLVEHLRQA HGLQVAKPAA
910 920 930 940 950
SPGAEPRTPA ERAPRDSPDG RAPRSPSPAP ENTPSDPADQ GARTPSKGPP
960 970 980 990
APAPAPGGGG GHRYCRLCNI RFSSLSTFIA HKKYYCSSHA AEHVK
Length:995
Mass (Da):105,984
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i293255B28151ECB8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF006492 mRNA Translation: AAC53292.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS22733.1

NCBI Reference Sequences

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RefSeqi
NP_033595.1, NM_009569.4
XP_006530914.1, XM_006530851.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.3105
Mm.390068

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000054052; ENSMUSP00000058037; ENSMUSG00000049577

Database of genes from NCBI RefSeq genomes

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GeneIDi
22761

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:22761

UCSC genome browser

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UCSCi
uc009nsj.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006492 mRNA Translation: AAC53292.1
CCDSiCCDS22733.1
RefSeqiNP_033595.1, NM_009569.4
XP_006530914.1, XM_006530851.3
UniGeneiMm.3105
Mm.390068

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SRKNMR-A328-360[»]
2MPLNMR-A100-226[»]
ProteinModelPortaliO35615
SMRiO35615
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204687, 11 interactors
CORUMiO35615
DIPiDIP-48414N
IntActiO35615, 13 interactors
MINTiO35615
STRINGi10090.ENSMUSP00000058037

PTM databases

iPTMnetiO35615
PhosphoSitePlusiO35615

Proteomic databases

MaxQBiO35615
PaxDbiO35615
PeptideAtlasiO35615
PRIDEiO35615

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054052; ENSMUSP00000058037; ENSMUSG00000049577
GeneIDi22761
KEGGimmu:22761
UCSCiuc009nsj.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
161882
MGIiMGI:1095400 Zfpm1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
HOGENOMiHOG000112626
HOVERGENiHBG101018
InParanoidiO35615
KOiK17441
OMAiDVNEEHY
OrthoDBi76702at2759
PhylomeDBiO35615
TreeFamiTF331342

Enzyme and pathway databases

ReactomeiR-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Apaf1 mouse
EvolutionaryTraceiO35615

Protein Ontology

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PROi
PR:O35615

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049577 Expressed in 230 organ(s), highest expression level in blood
CleanExiMM_ZFPM1
GenevisibleiO35615 MM

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOG1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35615
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 1, 1998
Last modified: January 16, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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