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Protein

Secretory carrier-associated membrane protein 3

Gene

Scamp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: MGI
  • protein transport Source: GO_Central
  • response to organic substance Source: MGI
  • response to retinoic acid Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 3
Short name:
Secretory carrier membrane protein 3
Gene namesi
Name:Scamp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1346346 Scamp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 168CytoplasmicSequence analysisAdd BLAST168
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 349CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912581 – 349Secretory carrier-associated membrane protein 3Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Modified residuei37PhosphothreonineBy similarity1
Modified residuei41PhosphotyrosineBy similarity1
Modified residuei53PhosphotyrosineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei78PhosphoserineCombined sources1
Modified residuei85PhosphotyrosineCombined sources1
Modified residuei87PhosphoserineBy similarity1
Cross-linki315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Post-translational modificationi

Monoubiquitinated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO35609
MaxQBiO35609
PaxDbiO35609
PRIDEiO35609

PTM databases

iPTMnetiO35609
PhosphoSitePlusiO35609
SwissPalmiO35609

Expressioni

Gene expression databases

BgeeiENSMUSG00000028049 Expressed in 290 organ(s), highest expression level in embryo
CleanExiMM_SCAMP3
ExpressionAtlasiO35609 baseline and differential
GenevisibleiO35609 MM

Interactioni

Subunit structurei

Interacts with NEDD4 and NEDD4L and TSG101 (By similarity). Interacts with RNF126.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204860, 1 interactor
IntActiO35609, 2 interactors
MINTiO35609
STRINGi10090.ENSMUSP00000029684

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiO35609
KOiK19995
OMAiFIFFAQD
TreeFamiTF313797

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35609-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQSRDTGNP FPDSGELDNP FQDPAVIQHR PSQQYATLDV YNPFENREPP
60 70 80 90 100
PAYEPPAPAP APLPPPSAPS VQSSRKLSPT EPRNYGSYST QASAAAATAE
110 120 130 140 150
LLKKQEELNR KAEELDRRER ELQHVALGGA GTRQNNWPPL PSFCPVKPCF
160 170 180 190 200
FQDISMEIPQ EFQKTVSTMY YLWMCSTLAL LLNFFACLAR FCVDTGSGSG
210 220 230 240 250
FGLSMLWLLL FTPCSFVCWY RPMYKAFRSD SSFNFFVFFF IFFVQDVFFV
260 270 280 290 300
LQAIGIPGWG FSGWVTALVV VGSKPAVAVL MLLVALLFTG IAVLGIVMLK
310 320 330 340
RIHSLYRQTG ASFQKAQQEF AAGVFSNPAV RTAAANAAAG AAENAFRAP
Length:349
Mass (Da):38,458
Last modified:July 27, 2011 - v3
Checksum:i4963A582F56A560D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UXS0Q3UXS0_MOUSE
Secretory carrier-associated membra...
Scamp3
350Annotation score:
E9Q855E9Q855_MOUSE
Secretory carrier-associated membra...
Scamp3
315Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11F → S in AAB62721 (PubMed:9378760).Curated1
Sequence conflicti11F → S in AAG22800 (PubMed:11050114).Curated1
Sequence conflicti48E → EQ in AAH02021 (PubMed:16141072).Curated1
Sequence conflicti61A → S in AAH02021 (PubMed:16141072).Curated1
Sequence conflicti111K → T in AAB62721 (PubMed:9378760).Curated1
Sequence conflicti284V → D in AAB62721 (PubMed:9378760).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005036 mRNA Translation: AAB62721.1
AF295403 mRNA Translation: AAG22800.1
AK160549 mRNA Translation: BAE35865.1
CH466547 Genomic DNA Translation: EDL15232.1
BC002021 mRNA Translation: AAH02021.1
CCDSiCCDS50959.1
RefSeqiNP_001296838.1, NM_001309909.1
NP_001296839.1, NM_001309910.1
NP_036016.2, NM_011886.3
UniGeneiMm.257052

Genome annotation databases

EnsembliENSMUST00000029684; ENSMUSP00000029684; ENSMUSG00000028049
GeneIDi24045
KEGGimmu:24045
UCSCiuc008pxw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005036 mRNA Translation: AAB62721.1
AF295403 mRNA Translation: AAG22800.1
AK160549 mRNA Translation: BAE35865.1
CH466547 Genomic DNA Translation: EDL15232.1
BC002021 mRNA Translation: AAH02021.1
CCDSiCCDS50959.1
RefSeqiNP_001296838.1, NM_001309909.1
NP_001296839.1, NM_001309910.1
NP_036016.2, NM_011886.3
UniGeneiMm.257052

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204860, 1 interactor
IntActiO35609, 2 interactors
MINTiO35609
STRINGi10090.ENSMUSP00000029684

PTM databases

iPTMnetiO35609
PhosphoSitePlusiO35609
SwissPalmiO35609

Proteomic databases

EPDiO35609
MaxQBiO35609
PaxDbiO35609
PRIDEiO35609

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029684; ENSMUSP00000029684; ENSMUSG00000028049
GeneIDi24045
KEGGimmu:24045
UCSCiuc008pxw.1 mouse

Organism-specific databases

CTDi10067
MGIiMGI:1346346 Scamp3

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiO35609
KOiK19995
OMAiFIFFAQD
TreeFamiTF313797

Miscellaneous databases

PROiPR:O35609
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028049 Expressed in 290 organ(s), highest expression level in embryo
CleanExiMM_SCAMP3
ExpressionAtlasiO35609 baseline and differential
GenevisibleiO35609 MM

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM3_MOUSE
AccessioniPrimary (citable) accession number: O35609
Secondary accession number(s): Q3TUV6, Q99M48, Q9ERM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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