Angpt2

Functionⁱ

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	429	CalciumBy similarity	1
Metal bindingⁱ	431	CalciumBy similarity	1
Metal bindingⁱ	433	Calcium; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	435	Calcium; via carbonyl oxygenBy similarity	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
receptor tyrosine kinase binding Source: MGI
vascular endothelial growth factor receptor binding
Source: MGI
Traceable author statementⁱ
- 10051567

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 16778080
animal organ regeneration Source: Ensembl
blood vessel morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 15579434
blood vessel remodeling
Source: DFLAT
Traceable author statementⁱ
- 20299672
cellular response to growth factor stimulus Source: Ensembl
endoderm development
Source: MGI
Traceable author statementⁱ
- 10051567
germ cell development Source: Ensembl
glomerulus vasculature development Source: MGI
hemopoiesis
Source: DFLAT
Traceable author statementⁱ
- 20299672
maternal process involved in female pregnancy Source: Ensembl
negative regulation of angiogenesis
Source: MGI
Inferred from direct assayⁱ
- 9204896
negative regulation of blood vessel endothelial cell migration Source: MGI
negative regulation of cell-substrate adhesion
Source: MGI
Inferred from direct assayⁱ
- 9846489
negative regulation of positive chemotaxis Source: MGI
positive regulation of angiogenesis Source: MGI
regulation of angiogenesis
Source: DFLAT
Traceable author statementⁱ
- 20299672
response to activity Source: Ensembl
response to glucose Source: Ensembl
response to hypoxia Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to organic cyclic compound Source: Ensembl
response to radiation Source: Ensembl
Tie signaling pathway Source: MGI
transmembrane receptor protein tyrosine kinase signaling pathway
Source: MGI
Traceable author statementⁱ
- 8384837

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Angiogenesis, Differentiation
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-210993 Tie2 Signaling

Reactomeⁱ

R-MMU-210993 Tie2 Signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Angiopoietin-2 Short name: ANG-2
Gene namesⁱ	Name:Angpt2 Synonyms:Agpt2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:1202890 Angpt2

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000009114	19 – 496	Angiopoietin-2Add BLAST		478

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	89	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	119	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	133	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	151	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	240	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	284 ↔ 313	PROSITE-ProRule annotation
Glycosylationⁱ	304	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	433 ↔ 435	PROSITE-ProRule annotation
Disulfide bondⁱ	437 ↔ 450	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O35608
PaxDbⁱ	O35608
PRIDEⁱ	O35608

PTM databases

iPTMnetⁱ	O35608
PhosphoSitePlusⁱ	O35608

Expressionⁱ

Tissue specificityⁱ

Expressed only at sites of vascular remodeling.

Gene expression databases

Bgeeⁱ	ENSMUSG00000031465 Expressed in 197 organ(s), highest expression level in decidua
CleanExⁱ	MM_ANGPT2
ExpressionAtlasⁱ	O35608 baseline and differential
Genevisibleⁱ	O35608 MM

Interactionⁱ

Subunit structureⁱ

Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.By similarity

GO - Molecular functionⁱ

receptor tyrosine kinase binding Source: MGI
vascular endothelial growth factor receptor binding
Source: MGI
Traceable author statementⁱ
- 10051567

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	O35608, 1 interactor
STRINGⁱ	10090.ENSMUSP00000033846

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O35608
SMRⁱ	O35608
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	275 – 495	Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST		221

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	159 – 256	Sequence analysisAdd BLAST		98

Domainⁱ

The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.By similarity

Keywords - Domainⁱ

Coiled coil, Signal

Phylogenomic databases

eggNOGⁱ	KOG2579 Eukaryota ENOG410ZYS4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150824
HOGENOMⁱ	HOG000037128
HOVERGENⁱ	HBG001644
InParanoidⁱ	O35608
KEGG Orthology (KO) More...KOⁱ	K05466
OMAⁱ	DLMETVH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03M1
PhylomeDBⁱ	O35608
TreeFamⁱ	TF336658

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00087 FReD, 1 hit
Gene3Dⁱ	3.90.215.10, 1 hit 4.10.530.10, 1 hit
InterProⁱ	View protein in InterPro IPR028844 Ang-2 IPR036056 Fibrinogen-like_C IPR014716 Fibrinogen_a/b/g_C_1 IPR014715 Fibrinogen_a/b/g_C_2 IPR002181 Fibrinogen_a/b/g_C_dom IPR020837 Fibrinogen_CS
PANTHERⁱ	PTHR19143:SF199 PTHR19143:SF199, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00147 Fibrinogen_C, 1 hit
SMARTⁱ	View protein in SMART SM00186 FBG, 1 hit
SUPFAMⁱ	SSF56496 SSF56496, 1 hit
PROSITEⁱ	View protein in PROSITE PS00514 FIBRINOGEN_C_1, 1 hit PS51406 FIBRINOGEN_C_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O35608-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWQIIFLTFG WDLVLASAYS NFRKSVDSTG RRQYQVQNGP CSYTFLLPET 
        60         70         80         90        100
DSCRSSSSPY MSNAVQRDAP LDYDDSVQRL QVLENILENN TQWLMKLENY 
       110        120        130        140        150
IQDNMKKEMV EIQQNVVQNQ TAVMIEIGTS LLNQTAAQTR KLTDVEAQVL 
       160        170        180        190        200
NQTTRLELQL LQHSISTNKL EKQILDQTSE INKLQNKNSF LEQKVLDMEG 
       210        220        230        240        250
KHSEQLQSMK EQKDELQVLV SKQSSVIDEL EKKLVTATVN NSLLQKQQHD 
       260        270        280        290        300
LMETVNSLLT MMSSPNSKSS VAIRKEEQTT FRDCAEIFKS GLTTSGIYTL 
       310        320        330        340        350
TFPNSTEEIK AYCDMDVGGG GWTVIQHRED GSVDFQRTWK EYKEGFGSPL 
       360        370        380        390        400
GEYWLGNEFV SQLTGQHRYV LKIQLKDWEG NEAHSLYDHF YLAGEESNYR 
       410        420        430        440        450
IHLTGLTGTA GKISSISQPG SDFSTKDSDN DKCICKCSQM LSGGWWFDAC 
       460        470        480        490 
GPSNLNGQYY PQKQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF

Length:496

Mass (Da):56,576

Last modified:April 26, 2004 - v2

Checksum:ⁱE7563B498A0EF331

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	348	S → N in AAB63189 (PubMed:9204896).Curated		1
Sequence conflictⁱ	411	G → A in AAB63189 (PubMed:9204896).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF004326 mRNA Translation: AAB63189.1 AK019860 mRNA Translation: BAB31887.1 AK048622 mRNA Translation: BAC33396.1 AK156132 mRNA Translation: BAE33599.1 BC027216 mRNA Translation: AAH27216.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22125.1
NCBI Reference Sequences More...RefSeqⁱ	NP_031452.2, NM_007426.4
UniGeneⁱ	Mm.439874

Genome annotation databases

Ensemblⁱ	ENSMUST00000033846; ENSMUSP00000033846; ENSMUSG00000031465
GeneIDⁱ	11601
KEGGⁱ	mmu:11601
UCSC genome browser More...UCSCⁱ	uc009kzu.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35608	Angiopoietin 2		MOUSE		496	UniRef100_O35608

Protein	Similar proteins		Species	Score	Length	Source
O35608	Angiopoietin-2		RAT		496	UniRef90_O35608
Angiopoietin 2		MOUSE		496
Angiopoietin-2-like isoform 1		CRIGR		539
angiopoietin-2		MESAU		495
UPI00038C3547		MICOH		496
+8

Protein	Similar proteins		Species	Score	Length	Source
O35608	Angiopoietin-2	)	HUMAN		496	UniRef50_O15123
Angiopoietin-2		BOVIN		496
Angiopoietin-2		PIG		496
Angiopoietin-2		CANLF		495
Angiopoietin-2		RAT		496
+250

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF004326 mRNA Translation: AAB63189.1 AK019860 mRNA Translation: BAB31887.1 AK048622 mRNA Translation: BAC33396.1 AK156132 mRNA Translation: BAE33599.1 BC027216 mRNA Translation: AAH27216.1
CCDSⁱ	CCDS22125.1
RefSeqⁱ	NP_031452.2, NM_007426.4
UniGeneⁱ	Mm.439874

3D structure databases

ProteinModelPortalⁱ	O35608
SMRⁱ	O35608
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O35608, 1 interactor
STRINGⁱ	10090.ENSMUSP00000033846

PTM databases

iPTMnetⁱ	O35608
PhosphoSitePlusⁱ	O35608

Proteomic databases

MaxQBⁱ	O35608
PaxDbⁱ	O35608
PRIDEⁱ	O35608

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033846; ENSMUSP00000033846; ENSMUSG00000031465
GeneIDⁱ	11601
KEGGⁱ	mmu:11601
UCSCⁱ	uc009kzu.2 mouse

Organism-specific databases

CTDⁱ	285
MGIⁱ	MGI:1202890 Angpt2

Phylogenomic databases

eggNOGⁱ	KOG2579 Eukaryota ENOG410ZYS4 LUCA
GeneTreeⁱ	ENSGT00930000150824
HOGENOMⁱ	HOG000037128
HOVERGENⁱ	HBG001644
InParanoidⁱ	O35608
KOⁱ	K05466
OMAⁱ	DLMETVH
OrthoDBⁱ	EOG091G03M1
PhylomeDBⁱ	O35608
TreeFamⁱ	TF336658

Enzyme and pathway databases

Reactomeⁱ	R-MMU-210993 Tie2 Signaling

Reactomeⁱ

R-MMU-210993 Tie2 Signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O35608
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031465 Expressed in 197 organ(s), highest expression level in decidua
CleanExⁱ	MM_ANGPT2
ExpressionAtlasⁱ	O35608 baseline and differential
Genevisibleⁱ	O35608 MM

Family and domain databases

CDDⁱ	cd00087 FReD, 1 hit
Gene3Dⁱ	3.90.215.10, 1 hit 4.10.530.10, 1 hit
InterProⁱ	View protein in InterPro IPR028844 Ang-2 IPR036056 Fibrinogen-like_C IPR014716 Fibrinogen_a/b/g_C_1 IPR014715 Fibrinogen_a/b/g_C_2 IPR002181 Fibrinogen_a/b/g_C_dom IPR020837 Fibrinogen_CS
PANTHERⁱ	PTHR19143:SF199 PTHR19143:SF199, 1 hit
Pfamⁱ	View protein in Pfam PF00147 Fibrinogen_C, 1 hit
SMARTⁱ	View protein in SMART SM00186 FBG, 1 hit
SUPFAMⁱ	SSF56496 SSF56496, 1 hit
PROSITEⁱ	View protein in PROSITE PS00514 FIBRINOGEN_C_1, 1 hit PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANGP2_MOUSE
Accessionⁱ	O35608Primary (citable) accession number: O35608 Secondary accession number(s): Q3U1A1, Q9D2D2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	April 26, 2004
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O35608 (ANGP2_MOUSE)

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Angiopoietin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ