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Protein

Angiopoietin-2

Gene

Angpt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi429CalciumBy similarity1
Metal bindingi431CalciumBy similarity1
Metal bindingi433Calcium; via carbonyl oxygenBy similarity1
Metal bindingi435Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-210993 Tie2 Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-2
Short name:
ANG-2
Gene namesi
Name:Angpt2
Synonyms:Agpt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1202890 Angpt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000911419 – 496Angiopoietin-2Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi284 ↔ 313PROSITE-ProRule annotation
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi433 ↔ 435PROSITE-ProRule annotation
Disulfide bondi437 ↔ 450PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO35608
PaxDbiO35608
PRIDEiO35608

PTM databases

iPTMnetiO35608
PhosphoSitePlusiO35608

Expressioni

Tissue specificityi

Expressed only at sites of vascular remodeling.

Gene expression databases

BgeeiENSMUSG00000031465 Expressed in 197 organ(s), highest expression level in decidua
CleanExiMM_ANGPT2
ExpressionAtlasiO35608 baseline and differential
GenevisibleiO35608 MM

Interactioni

Subunit structurei

Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35608, 1 interactor
STRINGi10090.ENSMUSP00000033846

Structurei

3D structure databases

ProteinModelPortaliO35608
SMRiO35608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini275 – 495Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili159 – 256Sequence analysisAdd BLAST98

Domaini

The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.By similarity

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000037128
HOVERGENiHBG001644
InParanoidiO35608
KOiK05466
OMAiDLMETVH
OrthoDBiEOG091G03M1
PhylomeDBiO35608
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR028844 Ang-2
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF199 PTHR19143:SF199, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35608-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWQIIFLTFG WDLVLASAYS NFRKSVDSTG RRQYQVQNGP CSYTFLLPET
60 70 80 90 100
DSCRSSSSPY MSNAVQRDAP LDYDDSVQRL QVLENILENN TQWLMKLENY
110 120 130 140 150
IQDNMKKEMV EIQQNVVQNQ TAVMIEIGTS LLNQTAAQTR KLTDVEAQVL
160 170 180 190 200
NQTTRLELQL LQHSISTNKL EKQILDQTSE INKLQNKNSF LEQKVLDMEG
210 220 230 240 250
KHSEQLQSMK EQKDELQVLV SKQSSVIDEL EKKLVTATVN NSLLQKQQHD
260 270 280 290 300
LMETVNSLLT MMSSPNSKSS VAIRKEEQTT FRDCAEIFKS GLTTSGIYTL
310 320 330 340 350
TFPNSTEEIK AYCDMDVGGG GWTVIQHRED GSVDFQRTWK EYKEGFGSPL
360 370 380 390 400
GEYWLGNEFV SQLTGQHRYV LKIQLKDWEG NEAHSLYDHF YLAGEESNYR
410 420 430 440 450
IHLTGLTGTA GKISSISQPG SDFSTKDSDN DKCICKCSQM LSGGWWFDAC
460 470 480 490
GPSNLNGQYY PQKQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
Length:496
Mass (Da):56,576
Last modified:April 26, 2004 - v2
Checksum:iE7563B498A0EF331
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti348S → N in AAB63189 (PubMed:9204896).Curated1
Sequence conflicti411G → A in AAB63189 (PubMed:9204896).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004326 mRNA Translation: AAB63189.1
AK019860 mRNA Translation: BAB31887.1
AK048622 mRNA Translation: BAC33396.1
AK156132 mRNA Translation: BAE33599.1
BC027216 mRNA Translation: AAH27216.1
CCDSiCCDS22125.1
RefSeqiNP_031452.2, NM_007426.4
UniGeneiMm.439874

Genome annotation databases

EnsembliENSMUST00000033846; ENSMUSP00000033846; ENSMUSG00000031465
GeneIDi11601
KEGGimmu:11601
UCSCiuc009kzu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004326 mRNA Translation: AAB63189.1
AK019860 mRNA Translation: BAB31887.1
AK048622 mRNA Translation: BAC33396.1
AK156132 mRNA Translation: BAE33599.1
BC027216 mRNA Translation: AAH27216.1
CCDSiCCDS22125.1
RefSeqiNP_031452.2, NM_007426.4
UniGeneiMm.439874

3D structure databases

ProteinModelPortaliO35608
SMRiO35608
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35608, 1 interactor
STRINGi10090.ENSMUSP00000033846

PTM databases

iPTMnetiO35608
PhosphoSitePlusiO35608

Proteomic databases

MaxQBiO35608
PaxDbiO35608
PRIDEiO35608

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033846; ENSMUSP00000033846; ENSMUSG00000031465
GeneIDi11601
KEGGimmu:11601
UCSCiuc009kzu.2 mouse

Organism-specific databases

CTDi285
MGIiMGI:1202890 Angpt2

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000037128
HOVERGENiHBG001644
InParanoidiO35608
KOiK05466
OMAiDLMETVH
OrthoDBiEOG091G03M1
PhylomeDBiO35608
TreeFamiTF336658

Enzyme and pathway databases

ReactomeiR-MMU-210993 Tie2 Signaling

Miscellaneous databases

PROiPR:O35608
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031465 Expressed in 197 organ(s), highest expression level in decidua
CleanExiMM_ANGPT2
ExpressionAtlasiO35608 baseline and differential
GenevisibleiO35608 MM

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR028844 Ang-2
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF199 PTHR19143:SF199, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANGP2_MOUSE
AccessioniPrimary (citable) accession number: O35608
Secondary accession number(s): Q3U1A1, Q9D2D2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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