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Protein

Bone morphogenetic protein receptor type-2

Gene

Bmpr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).1 Publication

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei230ATPPROSITE-ProRule annotation1
Active sitei333Proton acceptorPROSITE-ProRule annotation1
Binding sitei351ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 217ATPPROSITE-ProRule annotation9
Nucleotide bindingi280 – 282ATPPROSITE-ProRule annotation3
Nucleotide bindingi337 – 338ATPPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • artery development Source: BHF-UCL
  • atrial septum morphogenesis Source: BHF-UCL
  • blood vessel remodeling Source: BHF-UCL
  • BMP signaling pathway Source: UniProtKB
  • brain development Source: Ensembl
  • cellular response to BMP stimulus Source: MGI
  • cellular response to starvation Source: Ensembl
  • chondrocyte development Source: MGI
  • endocardial cushion development Source: BHF-UCL
  • endochondral bone morphogenesis Source: AgBase
  • endothelial cell apoptotic process Source: MGI
  • endothelial cell proliferation Source: MGI
  • limb development Source: MGI
  • lung alveolus development Source: BHF-UCL
  • lymphangiogenesis Source: BHF-UCL
  • lymphatic endothelial cell differentiation Source: BHF-UCL
  • maternal placenta development Source: MGI
  • mesoderm formation Source: MGI
  • mitral valve morphogenesis Source: BHF-UCL
  • negative regulation of cell growth Source: MGI
  • negative regulation of cell proliferation involved in heart valve morphogenesis Source: BHF-UCL
  • negative regulation of chondrocyte proliferation Source: MGI
  • negative regulation of DNA biosynthetic process Source: MGI
  • negative regulation of systemic arterial blood pressure Source: MGI
  • negative regulation of vasoconstriction Source: BHF-UCL
  • outflow tract morphogenesis Source: BHF-UCL
  • outflow tract septum morphogenesis Source: BHF-UCL
  • pharyngeal arch artery morphogenesis Source: BHF-UCL
  • positive regulation of axon extension involved in axon guidance Source: UniProtKB
  • positive regulation of BMP signaling pathway Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of cartilage development Source: AgBase
  • positive regulation of endothelial cell migration Source: MGI
  • positive regulation of endothelial cell proliferation Source: MGI
  • positive regulation of epithelial cell migration Source: MGI
  • positive regulation of ossification Source: BHF-UCL
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • protein phosphorylation Source: MGI
  • proteoglycan biosynthetic process Source: AgBase
  • regulation of cell proliferation Source: MGI
  • regulation of lung blood pressure Source: BHF-UCL
  • retina vasculature development in camera-type eye Source: BHF-UCL
  • semi-lunar valve development Source: BHF-UCL
  • transcription by RNA polymerase II Source: MGI
  • transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI
  • tricuspid valve morphogenesis Source: BHF-UCL
  • venous blood vessel development Source: BHF-UCL
  • ventricular septum morphogenesis Source: BHF-UCL

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 3474
ReactomeiR-MMU-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-2 (EC:2.7.11.30)
Short name:
BMP type-2 receptor
Short name:
BMPR-2
Alternative name(s):
BRK-3
Bone morphogenetic protein receptor type II
Short name:
BMP type II receptor
Short name:
BMPR-II
Gene namesi
Name:Bmpr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1095407 Bmpr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 150ExtracellularSequence analysisAdd BLAST124
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 1038CytoplasmicSequence analysisAdd BLAST867

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002441627 – 1038Bone morphogenetic protein receptor type-2Add BLAST1012

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 66By similarity
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi60 ↔ 84By similarity
Disulfide bondi94 ↔ 117By similarity
Disulfide bondi99 ↔ 116By similarity
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 123By similarity
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei379PhosphothreonineBy similarity1
Modified residuei586PhosphoserineBy similarity1
Modified residuei680PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei843PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35607
PaxDbiO35607
PeptideAtlasiO35607
PRIDEiO35607

PTM databases

iPTMnetiO35607
PhosphoSitePlusiO35607
SwissPalmiO35607

Expressioni

Gene expression databases

BgeeiENSMUSG00000067336
GenevisibleiO35607 MM

Interactioni

Subunit structurei

Interacts with GDF5.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Prkg1P0C6054EBI-527224,EBI-6991999

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198373, 4 interactors
ELMiO35607
IntActiO35607, 4 interactors
MINTiO35607
STRINGi10090.ENSMUSP00000084701

Structurei

3D structure databases

ProteinModelPortaliO35607
SMRiO35607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 504Protein kinasePROSITE-ProRule annotationAdd BLAST302

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 194Poly-Ala4
Compositional biasi547 – 550Poly-Ser4
Compositional biasi610 – 618Poly-Thr9
Compositional biasi901 – 908Poly-Asn8

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653 Eukaryota
ENOG410XS2Z LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000043088
HOVERGENiHBG050705
InParanoidiO35607
KOiK04671
OMAiSTEPLDC
OrthoDBiEOG091G03YO
PhylomeDBiO35607
TreeFamiTF314724

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR015770 BMPR2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PTHR23255:SF63 PTHR23255:SF63, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR
60 70 80 90 100
ISHENGTILC SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV
110 120 130 140 150
VTTTPPSIQN GTYRFCCCST DLCNVNFTEN FPPPDTTPLS PPHSFNRDET
160 170 180 190 200
IIIALASVSV LAVLIVALCF GYRMLTGDRK QGLHSMNMME AAAAEPSLDL
210 220 230 240 250
DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP
260 270 280 290 300
LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS
310 320 330 340 350
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS
360 370 380 390 400
DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA
410 420 430 440 450
LKQVDMYALG LIYWEVFMRC TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ
460 470 480 490 500
VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER
510 520 530 540 550
MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI GPYPDYSSSS
560 570 580 590 600
YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS
610 620 630 640 650
PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG
660 670 680 690 700
PTPVCLQLTE EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS
710 720 730 740 750
STSSSLLYPL IKLAVEVTGQ QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN
760 770 780 790 800
LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN LKQVETGVAK MNTINAAEPH
810 820 830 840 850
VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA HRSQEMLQNQ
860 870 880 890 900
FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT
910 920 930 940 950
NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD
960 970 980 990 1000
GSSIQIGEST QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV
1010 1020 1030
NNNGSDRAVH SKSSTAVYLA EGGTATTTVS KDIGMNCL
Length:1,038
Mass (Da):115,020
Last modified:January 1, 1998 - v1
Checksum:i4106945DC63250E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003942 mRNA Translation: AAB63042.1
U78048 mRNA Translation: AAB87638.1
CCDSiCCDS35588.1
PIRiJC5527
RefSeqiNP_031587.1, NM_007561.4
UniGeneiMm.391654
Mm.7106

Genome annotation databases

EnsembliENSMUST00000087435; ENSMUSP00000084701; ENSMUSG00000067336
GeneIDi12168
KEGGimmu:12168
UCSCiuc007bdz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBMPR2_MOUSE
AccessioniPrimary (citable) accession number: O35607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: July 18, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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