UniProtKB - O35599 (OPSG_MOUSE)

BLAST

>sp|O35599|OPSG_MOUSE Medium-wave-sensitive opsin 1 OS=Mus musculus OX=10090 GN=Opn1mw PE=1 SV=1
MAQRLTGEQTLDHYEDSTHASIFTYTNSNSTKGPFEGPNYHIAPRWVYHLTSTWMILVVV
ASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPL
CVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAIWTA
PPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLA
IRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVAS
LPSYFAKSATIYNPIIYVFMNRQFRNCILHLFGKKVDDSSELSSTSKTEVSSVSSVSPA

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History
Entry version 131 (07 Nov 2018)
Sequence version 1 (01 Jan 1998)
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Protein

Medium-wave-sensitive opsin 1

Gene

Opn1mw

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

GO - Molecular functionⁱ

G protein-coupled photoreceptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding Source: UniProtKB
photoreceptor activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to light stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phototransduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytokinesis Source: MGI
protein-chromophore linkage Source: UniProtKB-KW
visual perception Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process	Sensory transduction, Vision
Ligand	Chromophore

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2187335 The retinoid cycle in cones (daylight vision) R-MMU-418594 G alpha (i) signalling events R-MMU-419771 Opsins

Reactomeⁱ

R-MMU-2187335 The retinoid cycle in cones (daylight vision)
R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Medium-wave-sensitive opsin 1 Alternative name(s): Green cone photoreceptor pigment Green-sensitive opsin Short name: M opsin Medium wavelength-sensitive cone opsin
Gene namesⁱ	Name:Opn1mw Synonyms:Gcp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:1097692 Opn1mw

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 47	ExtracellularSequence analysisAdd BLAST	47
Transmembraneⁱ	48 – 72	Helical; Name=1Sequence analysisAdd BLAST	25
Topological domainⁱ	73 – 84	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	85 – 110	Helical; Name=2Sequence analysisAdd BLAST	26
Topological domainⁱ	111 – 124	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	125 – 144	Helical; Name=3Sequence analysisAdd BLAST	20
Topological domainⁱ	145 – 163	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	164 – 187	Helical; Name=4Sequence analysisAdd BLAST	24
Topological domainⁱ	188 – 213	ExtracellularSequence analysisAdd BLAST	26
Transmembraneⁱ	214 – 241	Helical; Name=5Sequence analysisAdd BLAST	28
Topological domainⁱ	242 – 263	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	264 – 287	Helical; Name=6Sequence analysisAdd BLAST	24
Topological domainⁱ	288 – 295	ExtracellularSequence analysis	8
Transmembraneⁱ	296 – 320	Helical; Name=7Sequence analysisAdd BLAST	25
Topological domainⁱ	321 – 359	CytoplasmicSequence analysisAdd BLAST	39

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197786	1 – 359	Medium-wave-sensitive opsin 1Add BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	29	N-linked (GlcNAc...) asparagineCurated	1
Disulfide bondⁱ	121 ↔ 198	PROSITE-ProRule annotation
Modified residueⁱ	307	N6-(retinylidene)lysine	1

Post-translational modificationⁱ

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	O35599
PRIDEⁱ	O35599

PTM databases

PhosphoSitePlusⁱ	O35599

PhosphoSitePlusⁱ

O35599

Expressionⁱ

Tissue specificityⁱ

Expressed in cone photoreceptor cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000031394 Expressed in 28 organ(s), highest expression level in retina
ExpressionAtlasⁱ	O35599 baseline and differential
Genevisibleⁱ	O35599 MM

Interactionⁱ

Subunit structureⁱ

Monomer. Homodimer. Homotetramer.By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000033771

STRINGⁱ

10090.ENSMUSP00000033771

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O35599
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000253932
HOVERGENⁱ	HBG107442
InParanoidⁱ	O35599
KEGG Orthology (KO) More...KOⁱ	K04251
OMAⁱ	FCWGPYT
PhylomeDBⁱ	O35599
TreeFamⁱ	TF324998

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001760 Opsin IPR000378 Opsin_red/grn IPR027430 Retinal_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00238 OPSIN PR00575 OPSINREDGRN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O35599-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL 
        60         70         80         90        100
TSTWMILVVV ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII 
       110        120        130        140        150
ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV 
       160        170        180        190        200
CKPFGNVRFD AKLATVGIVF SWVWAAIWTA PPIFGWSRYW PYGLKTSCGP 
       210        220        230        240        250
DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE 
       260        270        280        290        300
SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS 
       310        320        330        340        350
LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV 

SSVSSVSPA

Length:359

Mass (Da):40,218

Last modified:January 1, 1998 - v1

Checksum:ⁱ1BB5F531A6FAE357

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1AYN7	B1AYN7_MOUSE	Medium-wave-sensitive opsin 1 Medium-wave-sensitive opsin 1	Opn1mw	389	Annotation score:
B1AYN8	B1AYN8_MOUSE	Medium-wave-sensitive opsin 1 Medium-wave-sensitive opsin 1	Opn1mw	164	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF011389 mRNA Translation: AAB64302.1 AF190672 mRNA Translation: AAG17991.1 AF191085 AF191084 Genomic DNA Translation: AAG17992.1 BC014826 mRNA Translation: AAH14826.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30220.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032132.1, NM_008106.2
UniGeneⁱ	Mm.284825

Genome annotation databases

Ensemblⁱ	ENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394
GeneIDⁱ	14539
KEGGⁱ	mmu:14539
UCSC genome browser More...UCSCⁱ	uc009tnv.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35599	Uncharacterized protein		MOUSE		389	UniRef90_O35599
Medium-wave-sensitive opsin 1 (Fragment)		ELLLU		29
Medium-wave-sensitive opsin 1		CRIGR		339
UPI000A31A4B7		MUSCR		389
Medium-wave-sensitive opsin 1		MOUSE		389
+1

Protein	Similar proteins		Species	Score	Length	Source
O35599	Long-wave-sensitive opsin 1	)	HUMAN		364	UniRef50_P04000
Long-wave-sensitive opsin 1		CANLF		364
Long-wave-sensitive opsin 1		CAPHI		364
Medium-wave-sensitive opsin 1		SCICA		364
Long-wave-sensitive opsin 1		BOVIN		364
+446

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF011389 mRNA Translation: AAB64302.1 AF190672 mRNA Translation: AAG17991.1 AF191085 AF191084 Genomic DNA Translation: AAG17992.1 BC014826 mRNA Translation: AAH14826.1
CCDSⁱ	CCDS30220.1
RefSeqⁱ	NP_032132.1, NM_008106.2
UniGeneⁱ	Mm.284825

3D structure databases

ProteinModelPortalⁱ	O35599
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000033771

STRINGⁱ

10090.ENSMUSP00000033771

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	O35599

PhosphoSitePlusⁱ

O35599

Proteomic databases

PaxDbⁱ	O35599
PRIDEⁱ	O35599

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394
GeneIDⁱ	14539
KEGGⁱ	mmu:14539
UCSCⁱ	uc009tnv.1 mouse

Organism-specific databases

CTDⁱ	2652
MGIⁱ	MGI:1097692 Opn1mw

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000253932
HOVERGENⁱ	HBG107442
InParanoidⁱ	O35599
KOⁱ	K04251
OMAⁱ	FCWGPYT
PhylomeDBⁱ	O35599
TreeFamⁱ	TF324998

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2187335 The retinoid cycle in cones (daylight vision) R-MMU-418594 G alpha (i) signalling events R-MMU-419771 Opsins

Reactomeⁱ

R-MMU-2187335 The retinoid cycle in cones (daylight vision)
R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O35599
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031394 Expressed in 28 organ(s), highest expression level in retina
ExpressionAtlasⁱ	O35599 baseline and differential
Genevisibleⁱ	O35599 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001760 Opsin IPR000378 Opsin_red/grn IPR027430 Retinal_BS
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00238 OPSIN PR00575 OPSINREDGRN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OPSG_MOUSE
Accessionⁱ	O35599Primary (citable) accession number: O35599 Secondary accession number(s): Q548Z4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniParc

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UniProtKB - O35599 (OPSG_MOUSE)

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Medium-wave-sensitive opsin 1

Opn1mw

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ