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Protein

Medium-wave-sensitive opsin 1

Gene

Opn1mw

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

GO - Molecular functioni

  • G protein-coupled photoreceptor activity Source: GO_Central
  • identical protein binding Source: UniProtKB
  • photoreceptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Enzyme and pathway databases

ReactomeiR-MMU-2187335 The retinoid cycle in cones (daylight vision)
R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Medium-wave-sensitive opsin 1
Alternative name(s):
Green cone photoreceptor pigment
Green-sensitive opsin
Short name:
M opsin
Medium wavelength-sensitive cone opsin
Gene namesi
Name:Opn1mw
Synonyms:Gcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1097692 Opn1mw

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 72Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini73 – 84CytoplasmicSequence analysisAdd BLAST12
Transmembranei85 – 110Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini111 – 124ExtracellularSequence analysisAdd BLAST14
Transmembranei125 – 144Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini145 – 163CytoplasmicSequence analysisAdd BLAST19
Transmembranei164 – 187Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini188 – 213ExtracellularSequence analysisAdd BLAST26
Transmembranei214 – 241Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini242 – 263CytoplasmicSequence analysisAdd BLAST22
Transmembranei264 – 287Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini288 – 295ExtracellularSequence analysis8
Transmembranei296 – 320Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini321 – 359CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001977861 – 359Medium-wave-sensitive opsin 1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Modified residuei307N6-(retinylidene)lysine1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35599
PRIDEiO35599

PTM databases

PhosphoSitePlusiO35599

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000031394 Expressed in 28 organ(s), highest expression level in retina
ExpressionAtlasiO35599 baseline and differential
GenevisibleiO35599 MM

Interactioni

Subunit structurei

Monomer. Homodimer. Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033771

Structurei

3D structure databases

ProteinModelPortaliO35599
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000253932
HOVERGENiHBG107442
InParanoidiO35599
KOiK04251
OMAiFCWGPYT
PhylomeDBiO35599
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR000378 Opsin_red/grn
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00575 OPSINREDGRN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35599-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL
60 70 80 90 100
TSTWMILVVV ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII
110 120 130 140 150
ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV
160 170 180 190 200
CKPFGNVRFD AKLATVGIVF SWVWAAIWTA PPIFGWSRYW PYGLKTSCGP
210 220 230 240 250
DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE
260 270 280 290 300
SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS
310 320 330 340 350
LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV

SSVSSVSPA
Length:359
Mass (Da):40,218
Last modified:January 1, 1998 - v1
Checksum:i1BB5F531A6FAE357
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AYN7B1AYN7_MOUSE
Medium-wave-sensitive opsin 1
Opn1mw
389Annotation score:
B1AYN8B1AYN8_MOUSE
Medium-wave-sensitive opsin 1
Opn1mw
164Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011389 mRNA Translation: AAB64302.1
AF190672 mRNA Translation: AAG17991.1
AF191085
, AF191080, AF191081, AF191082, AF191083, AF191084 Genomic DNA Translation: AAG17992.1
BC014826 mRNA Translation: AAH14826.1
CCDSiCCDS30220.1
RefSeqiNP_032132.1, NM_008106.2
UniGeneiMm.284825

Genome annotation databases

EnsembliENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394
GeneIDi14539
KEGGimmu:14539
UCSCiuc009tnv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011389 mRNA Translation: AAB64302.1
AF190672 mRNA Translation: AAG17991.1
AF191085
, AF191080, AF191081, AF191082, AF191083, AF191084 Genomic DNA Translation: AAG17992.1
BC014826 mRNA Translation: AAH14826.1
CCDSiCCDS30220.1
RefSeqiNP_032132.1, NM_008106.2
UniGeneiMm.284825

3D structure databases

ProteinModelPortaliO35599
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033771

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO35599

Proteomic databases

PaxDbiO35599
PRIDEiO35599

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394
GeneIDi14539
KEGGimmu:14539
UCSCiuc009tnv.1 mouse

Organism-specific databases

CTDi2652
MGIiMGI:1097692 Opn1mw

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000253932
HOVERGENiHBG107442
InParanoidiO35599
KOiK04251
OMAiFCWGPYT
PhylomeDBiO35599
TreeFamiTF324998

Enzyme and pathway databases

ReactomeiR-MMU-2187335 The retinoid cycle in cones (daylight vision)
R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Miscellaneous databases

PROiPR:O35599
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031394 Expressed in 28 organ(s), highest expression level in retina
ExpressionAtlasiO35599 baseline and differential
GenevisibleiO35599 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR000378 Opsin_red/grn
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00575 OPSINREDGRN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPSG_MOUSE
AccessioniPrimary (citable) accession number: O35599
Secondary accession number(s): Q548Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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