Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein patched homolog 2

Gene

Ptch2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

GO - Molecular functioni

  • hedgehog family protein binding Source: MGI
  • hedgehog receptor activity Source: GO_Central
  • smoothened binding Source: MGI

GO - Biological processi

  • cell fate determination Source: MGI
  • epidermal cell fate specification Source: MGI
  • epidermis development Source: MGI
  • hair cycle Source: MGI
  • positive regulation of epidermal cell differentiation Source: MGI
  • skin development Source: MGI
  • smoothened signaling pathway Source: GO_Central

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein patched homolog 2
Short name:
PTC2
Gene namesi
Name:Ptch2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1095405 Ptch2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 394ExtracellularSequence analysisAdd BLAST316
Transmembranei395 – 414HelicalSequence analysisAdd BLAST20
Topological domaini415 – 428CytoplasmicSequence analysisAdd BLAST14
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 457ExtracellularSequence analysis8
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 501CytoplasmicSequence analysisAdd BLAST23
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 531ExtracellularSequence analysis9
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 686CytoplasmicSequence analysisAdd BLAST134
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 963ExtracellularSequence analysisAdd BLAST256
Transmembranei964 – 984HelicalSequence analysisAdd BLAST21
Topological domaini985 – 991CytoplasmicSequence analysis7
Transmembranei992 – 1012HelicalSequence analysisAdd BLAST21
Topological domaini1013ExtracellularSequence analysis1
Transmembranei1014 – 1034HelicalSequence analysisAdd BLAST21
Topological domaini1035 – 1064CytoplasmicSequence analysisAdd BLAST30
Transmembranei1065 – 1085HelicalSequence analysisAdd BLAST21
Topological domaini1086ExtracellularSequence analysis1
Transmembranei1087 – 1107HelicalSequence analysisAdd BLAST21
Topological domaini1108 – 1182CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059711 – 1182Protein patched homolog 2Add BLAST1182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi812N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35595
PRIDEiO35595

PTM databases

iPTMnetiO35595
PhosphoSitePlusiO35595

Expressioni

Tissue specificityi

Expressed in epithelial cells of the developing hair, tooth and whisker.

Developmental stagei

Detected in 8.5 to 17.5 dpc embryos.

Gene expression databases

BgeeiENSMUSG00000028681 Expressed in 225 organ(s), highest expression level in brown adipose tissue
CleanExiMM_PTCH2
ExpressionAtlasiO35595 baseline and differential
GenevisibleiO35595 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030443

Structurei

3D structure databases

ProteinModelPortaliO35595
SMRiO35595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 552SSDPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the patched family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1935 Eukaryota
ENOG410XRKU LUCA
GeneTreeiENSGT00900000140845
HOGENOMiHOG000231331
HOVERGENiHBG003801
InParanoidiO35595
KOiK11101
OMAiQERTGEC
OrthoDBiEOG091G0LGQ
PhylomeDBiO35595
TreeFamiTF106489

Family and domain databases

InterProiView protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD
IPR004766 TM_rcpt_patched
PfamiView protein in Pfam
PF02460 Patched, 1 hit
PF12349 Sterol-sensing, 1 hit
TIGRFAMsiTIGR00918 2A060602, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35595-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRPLSLGEL PPSYTPPARS SAPHILAGSL QAPLWLRAYF QGLLFSLGCR
60 70 80 90 100
IQKHCGKVLF LGLVAFGALA LGLRVAVIET DLEQLWVEVG SRVSQELHYT
110 120 130 140 150
KEKLGEEAAY TSQMLIQTAH QEGGNVLTPE ALDLHLQAAL TASKVQVSLY
160 170 180 190 200
GKSWDLNKIC YKSGVPLIEN GMIERMIEKL FPCVILTPLD CFWEGAKLQG
210 220 230 240 250
GSAYLPGRPD IQWTNLDPQQ LLEELGPFAS LEGFRELLDK AQVGQAYVGR
260 270 280 290 300
PCLDPDDPHC PPSAPNRHSR QAPNVAQELS GGCHGFSHKF MHWQEELLLG
310 320 330 340 350
GTARDLQGQL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQASM
360 370 380 390 400
VLQAWQRRFV QLAQEALPAN ASQQIHAFSS TTLDDILRAF SEVSTTRVVG
410 420 430 440 450
GYLLMLAYAC VTMLRWDCAQ SQGAVGLAGV LLVALAVASG LGLCALLGIT
460 470 480 490 500
FNAATTQVLP FLALGIGVDD IFLLAHAFTK APPDTPLPER MGECLRSTGT
510 520 530 540 550
SVALTSVNNM VAFFMAALVP IPALRAFSLQ AAIVVGCNFA AVMLVFPAIL
560 570 580 590 600
SLDLRRRHRQ RLDVLCCFSS PCSAQVIQML PQELGDRAVP VGIAHLTATV
610 620 630 640 650
QAFTHCEASS QHVVTILPPQ AHLLSPASDP LGSELYSPGG STRDLLSQEE
660 670 680 690 700
GTGPQAACRP LLCAHWTLAH FARYQFAPLL LQTRAKALVL LFFGALLGLS
710 720 730 740 750
LYGATLVQDG LALTDVVPRG TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA
760 770 780 790 800
HSQRALFDLH QRFSSLKAVL PPPATQAPRT WLHYYRSWLQ GIQAAFDQDW
810 820 830 840 850
ASGRITCHSY RNGSEDGALA YKLLIQTGNA QEPLDFSQLT TRKLVDKEGL
860 870 880 890 900
IPPELFYMGL TVWVSSDPLG LAASQANFYP PPPEWLHDKY DTTGENLRIP
910 920 930 940 950
AAQPLEFAQF PFLLHGLQKT ADFVEAIEGA RAACTEAGQA GVHAYPSGSP
960 970 980 990 1000
FLFWEQYLGL RRCFLLAVCI LLVCTFLVCA LLLLSPWTAG LIVLVLAMMT
1010 1020 1030 1040 1050
VELFGIMGFL GIKLSAIPVV ILVASIGIGV EFTVHVALGF LTSHGSRNLR
1060 1070 1080 1090 1100
AASALEQTFA PVTDGAVSTL LGLLMLAGSN FDFIIRYFFV VLTVLTLLGL
1110 1120 1130 1140 1150
LHGLLLLPVL LSILGPPPQV VQVYKESPQT LNSAAPQRGG LRWDRPPTLP
1160 1170 1180
QSFARVTTSM TVALHPPPLP GAYVHPASEE PT
Length:1,182
Mass (Da):128,586
Last modified:August 1, 1998 - v2
Checksum:i715233D912C352F2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RG83D6RG83_MOUSE
Protein patched homolog 2
Ptch2
337Annotation score:
F6XYY1F6XYY1_MOUSE
Protein patched homolog 2
Ptch2
170Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133482
, AJ133483, AJ133484, AJ133485 Genomic DNA Translation: CAC88120.1
AL671866 Genomic DNA Translation: CAM26330.1
AB010833 mRNA Translation: BAA24691.1
CCDSiCCDS18526.1
PIRiT13952
RefSeqiNP_032984.1, NM_008958.3
UniGeneiMm.287037

Genome annotation databases

EnsembliENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681
GeneIDi19207
KEGGimmu:19207
UCSCiuc008uhx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133482
, AJ133483, AJ133484, AJ133485 Genomic DNA Translation: CAC88120.1
AL671866 Genomic DNA Translation: CAM26330.1
AB010833 mRNA Translation: BAA24691.1
CCDSiCCDS18526.1
PIRiT13952
RefSeqiNP_032984.1, NM_008958.3
UniGeneiMm.287037

3D structure databases

ProteinModelPortaliO35595
SMRiO35595
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030443

PTM databases

iPTMnetiO35595
PhosphoSitePlusiO35595

Proteomic databases

PaxDbiO35595
PRIDEiO35595

Protocols and materials databases

DNASUi19207
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681
GeneIDi19207
KEGGimmu:19207
UCSCiuc008uhx.1 mouse

Organism-specific databases

CTDi8643
MGIiMGI:1095405 Ptch2

Phylogenomic databases

eggNOGiKOG1935 Eukaryota
ENOG410XRKU LUCA
GeneTreeiENSGT00900000140845
HOGENOMiHOG000231331
HOVERGENiHBG003801
InParanoidiO35595
KOiK11101
OMAiQERTGEC
OrthoDBiEOG091G0LGQ
PhylomeDBiO35595
TreeFamiTF106489

Miscellaneous databases

PROiPR:O35595
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028681 Expressed in 225 organ(s), highest expression level in brown adipose tissue
CleanExiMM_PTCH2
ExpressionAtlasiO35595 baseline and differential
GenevisibleiO35595 MM

Family and domain databases

InterProiView protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD
IPR004766 TM_rcpt_patched
PfamiView protein in Pfam
PF02460 Patched, 1 hit
PF12349 Sterol-sensing, 1 hit
TIGRFAMsiTIGR00918 2A060602, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTC2_MOUSE
AccessioniPrimary (citable) accession number: O35595
Secondary accession number(s): A2AE82, Q546T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again