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Protein

CD151 antigen

Gene

Cd151

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: MGI
  • cell surface receptor signaling pathway Source: GO_Central
  • positive regulation of cell migration Source: MGI
  • positive regulation of endocytosis Source: MGI
  • T cell proliferation Source: MGI
  • wound healing, spreading of cells Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-446107 Type I hemidesmosome assembly

Names & Taxonomyi

Protein namesi
Recommended name:
CD151 antigen
Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name:
PETA-3
CD_antigen: CD151
Gene namesi
Name:Cd151
Synonyms:Peta3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1096360 Cd151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 57ExtracellularSequence analysisAdd BLAST18
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 91CytoplasmicSequence analysisAdd BLAST13
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 221ExtracellularSequence analysisAdd BLAST109
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 253CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192321 – 253CD151 antigenAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi11S-palmitoyl cysteineBy similarity1
Lipidationi15S-palmitoyl cysteineBy similarity1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi242S-palmitoyl cysteineBy similarity1
Lipidationi243S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiO35566
PaxDbiO35566
PeptideAtlasiO35566
PRIDEiO35566

PTM databases

iPTMnetiO35566
PhosphoSitePlusiO35566
SwissPalmiO35566

Expressioni

Gene expression databases

BgeeiENSMUSG00000025510 Expressed in 291 organ(s), highest expression level in sciatic nerve
CleanExiMM_CD151
ExpressionAtlasiO35566 baseline and differential
GenevisibleiO35566 MM

Interactioni

Subunit structurei

Interacts with integrins ITGA3:ITGB1, ITGA5:ITGB1, ITGA3:ITGB1 and ITGA6:ITGB4 and with CD9 and CD181. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198574, 1 interactor
IntActiO35566, 2 interactors
MINTiO35566
STRINGi10090.ENSMUSP00000061636

Structurei

3D structure databases

ProteinModelPortaliO35566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230651
HOVERGENiHBG107306
InParanoidiO35566
KOiK06537
OMAiCKTVVAG
OrthoDBiEOG091G0CQO
PhylomeDBiO35566
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O35566-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS
60 70 80 90 100
LLASSTYLAT AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII
110 120 130 140 150
FLLEIIAGIL AYVYYQQLNT ELKENLKDTM VKRYHQSGHE GVSSAVDKLQ
160 170 180 190 200
QEFHCCGSNN SQDWQDSEWI RSGEADSRVV PDSCCKTMVA GCGKRDHASN
210 220 230 240 250
IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL

EHY
Length:253
Mass (Da):28,246
Last modified:May 30, 2000 - v2
Checksum:iAEBEEBCE2D765F1B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSK8A0A1B0GSK8_MOUSE
Tetraspanin
Cd151
202Annotation score:
A0A1B0GRG3A0A1B0GRG3_MOUSE
CD151 antigen
Cd151
150Annotation score:
A0A1B0GSP0A0A1B0GSP0_MOUSE
CD151 antigen
Cd151
139Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237G → S in BAA22447 (PubMed:9294006).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89290 mRNA Translation: BAA22447.1
AF033620 Genomic DNA Translation: AAC25952.1
U89772 mRNA Translation: AAC25976.1
CCDSiCCDS22017.1
RefSeqiNP_001104519.1, NM_001111049.1
NP_001104520.1, NM_001111050.1
NP_033972.2, NM_009842.3
UniGeneiMm.30246
Mm.483720

Genome annotation databases

EnsembliENSMUST00000058746; ENSMUSP00000061636; ENSMUSG00000025510
ENSMUST00000106000; ENSMUSP00000101622; ENSMUSG00000025510
ENSMUST00000177840; ENSMUSP00000136331; ENSMUSG00000025510
GeneIDi12476
KEGGimmu:12476
UCSCiuc009kll.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89290 mRNA Translation: BAA22447.1
AF033620 Genomic DNA Translation: AAC25952.1
U89772 mRNA Translation: AAC25976.1
CCDSiCCDS22017.1
RefSeqiNP_001104519.1, NM_001111049.1
NP_001104520.1, NM_001111050.1
NP_033972.2, NM_009842.3
UniGeneiMm.30246
Mm.483720

3D structure databases

ProteinModelPortaliO35566
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198574, 1 interactor
IntActiO35566, 2 interactors
MINTiO35566
STRINGi10090.ENSMUSP00000061636

PTM databases

iPTMnetiO35566
PhosphoSitePlusiO35566
SwissPalmiO35566

Proteomic databases

MaxQBiO35566
PaxDbiO35566
PeptideAtlasiO35566
PRIDEiO35566

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058746; ENSMUSP00000061636; ENSMUSG00000025510
ENSMUST00000106000; ENSMUSP00000101622; ENSMUSG00000025510
ENSMUST00000177840; ENSMUSP00000136331; ENSMUSG00000025510
GeneIDi12476
KEGGimmu:12476
UCSCiuc009kll.2 mouse

Organism-specific databases

CTDi977
MGIiMGI:1096360 Cd151

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230651
HOVERGENiHBG107306
InParanoidiO35566
KOiK06537
OMAiCKTVVAG
OrthoDBiEOG091G0CQO
PhylomeDBiO35566
TreeFamiTF352892

Enzyme and pathway databases

ReactomeiR-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-446107 Type I hemidesmosome assembly

Miscellaneous databases

PROiPR:O35566
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025510 Expressed in 291 organ(s), highest expression level in sciatic nerve
CleanExiMM_CD151
ExpressionAtlasiO35566 baseline and differential
GenevisibleiO35566 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD151_MOUSE
AccessioniPrimary (citable) accession number: O35566
Secondary accession number(s): O89118
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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