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Protein

Fibroblast growth factor 10

Gene

Fgf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190370 FGFR1b ligand binding and activation
R-MMU-190377 FGFR2b ligand binding and activation
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 10
Short name:
FGF-10
Alternative name(s):
Keratinocyte growth factor 2
Gene namesi
Name:Fgf10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1099809 Fgf10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000000898237 – 209Fibroblast growth factor 10Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35565
PRIDEiO35565

PTM databases

PhosphoSitePlusiO35565

Expressioni

Tissue specificityi

Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart.

Gene expression databases

BgeeiENSMUSG00000021732 Expressed in 161 organ(s), highest expression level in intestine
CleanExiMM_FGF10
GenevisibleiO35565 MM

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199639, 1 interactor
STRINGi10090.ENSMUSP00000022246

Structurei

3D structure databases

ProteinModelPortaliO35565
SMRiO35565
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 63Poly-SerAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiO35565
KOiK04358
OMAiSSIPVTC
OrthoDBiEOG091G0NAY
PhylomeDBiO35565
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028252 FGF10
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF21 PTHR11486:SF21, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35565-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN
60 70 80 90 100
CSSSSSSFSS PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS
110 120 130 140 150
GTKNEDCPYS VLEITSVEIG VVAVKAINSN YYLAMNKKGK LYGSKEFNND
160 170 180 190 200
CKLKERIEEN GYNTYASFNW QHNGRQMYVA LNGKGAPRRG QKTRRKNTSA

HFLPMTIQT
Length:209
Mass (Da):23,597
Last modified:January 1, 1998 - v1
Checksum:i7FD22227BF4943CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89080 mRNA Translation: BAA22836.1
U94517 mRNA Translation: AAD00761.1
AK034742 mRNA Translation: BAC28816.1
AK045267 mRNA Translation: BAC32287.1
AK085244 mRNA Translation: BAC39398.1
AK141633 mRNA Translation: BAE24777.1
BC048229 mRNA Translation: AAH48229.1
CCDSiCCDS26795.1
RefSeqiNP_032028.1, NM_008002.4
UniGeneiMm.317323

Genome annotation databases

EnsembliENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732
GeneIDi14165
KEGGimmu:14165
UCSCiuc007ryv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89080 mRNA Translation: BAA22836.1
U94517 mRNA Translation: AAD00761.1
AK034742 mRNA Translation: BAC28816.1
AK045267 mRNA Translation: BAC32287.1
AK085244 mRNA Translation: BAC39398.1
AK141633 mRNA Translation: BAE24777.1
BC048229 mRNA Translation: AAH48229.1
CCDSiCCDS26795.1
RefSeqiNP_032028.1, NM_008002.4
UniGeneiMm.317323

3D structure databases

ProteinModelPortaliO35565
SMRiO35565
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199639, 1 interactor
STRINGi10090.ENSMUSP00000022246

PTM databases

PhosphoSitePlusiO35565

Proteomic databases

PaxDbiO35565
PRIDEiO35565

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732
GeneIDi14165
KEGGimmu:14165
UCSCiuc007ryv.2 mouse

Organism-specific databases

CTDi2255
MGIiMGI:1099809 Fgf10

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiO35565
KOiK04358
OMAiSSIPVTC
OrthoDBiEOG091G0NAY
PhylomeDBiO35565
TreeFamiTF317805

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190370 FGFR1b ligand binding and activation
R-MMU-190377 FGFR2b ligand binding and activation
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

PROiPR:O35565
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021732 Expressed in 161 organ(s), highest expression level in intestine
CleanExiMM_FGF10
GenevisibleiO35565 MM

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028252 FGF10
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF21 PTHR11486:SF21, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF10_MOUSE
AccessioniPrimary (citable) accession number: O35565
Secondary accession number(s): Q543V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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