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UniProtKB - O35552 (F263_RAT)

Protein

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Gene

Pfkfb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Synthesis and degradation of fructose 2,6-bisphosphate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei75Fructose 6-phosphateBy similarity1
Binding sitei99Fructose 6-phosphateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei125Sequence analysis1
Binding sitei127Fructose 6-phosphateBy similarity1
Binding sitei133Fructose 6-phosphateBy similarity1
Active sitei155Sequence analysis1
Binding sitei169Fructose 6-phosphateBy similarity1
Binding sitei190Fructose 6-phosphateBy similarity1
Binding sitei194Fructose 6-phosphateBy similarity1
Binding sitei253Fructose 2,6-bisphosphateBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei253Transition state stabilizerBy similarity1
Active sitei254Tele-phosphohistidine intermediateBy similarity1
Binding sitei260Fructose 2,6-bisphosphateBy similarity1
Sitei260Transition state stabilizerBy similarity1
Binding sitei266Fructose 2,6-bisphosphate; via amide nitrogenBy similarity1
Active sitei323Proton donor/acceptorBy similarity1
Binding sitei334Fructose 2,6-bisphosphateBy similarity1
Binding sitei348Fructose 2,6-bisphosphateBy similarity1
Binding sitei352Fructose 2,6-bisphosphateBy similarity1
Binding sitei363Fructose 2,6-bisphosphateBy similarity1
Sitei388Transition state stabilizerBy similarity1
Binding sitei389Fructose 2,6-bisphosphateBy similarity1
Binding sitei393Fructose 2,6-bisphosphateBy similarity1
Binding sitei425ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi42 – 50ATPBy similarity9
Nucleotide bindingi164 – 169ATPBy similarity6
Nucleotide bindingi345 – 348ATPBy similarity4
Nucleotide bindingi389 – 393ATPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 6-phosphofructo-2-kinase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • fructose-2,6-bisphosphate 2-phosphatase activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • brain development Source: RGD
  • fructose 2,6-bisphosphate metabolic process Source: RGD
  • fructose metabolic process Source: InterPro
  • regulation of glycolytic process Source: RGD
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Kinase, Multifunctional enzyme, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.46 5301

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-70171 Glycolysis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Short name:
6PF-2-K/Fru-2,6-P2ase 3
Short name:
PFK/FBPase 3
Alternative name(s):
6PF-2-K/Fru-2,6-P2ase brain-type isozyme
RB2K
Including the following 2 domains:
6-phosphofructo-2-kinase (EC:2.7.1.105)
Fructose-2,6-bisphosphatase (EC:3.1.3.46)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pfkfb3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Rat genome database

More...RGDi		619776 Pfkfb3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001799691 – 5556-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei490Phosphoserine; by AMPK and PKABy similarity1
Modified residuei492PhosphothreonineBy similarity1
Modified residuei496PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by AMPK stimulates activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O35552

PRoteomics IDEntifications database

More...PRIDEi		O35552

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O35552

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O35552

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000018911 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O35552 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O35552 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2043 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex

Protein interaction database and analysis system

More...IntActi		O35552, 2 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000062965

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O35552

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O35552

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 2456-phosphofructo-2-kinaseAdd BLAST245
Regioni246 – 555Fructose-2,6-bisphosphataseAdd BLAST310

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the phosphoglycerate mutase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0234 Eukaryota
COG0406 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153570

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG005628

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O35552

KEGG Orthology (KO)

More...KOi		K01103

Identification of Orthologs from Complete Genome Data

More...OMAi		HDSCEWL

Database of Orthologous Groups

More...OrthoDBi		EOG091G0A43

Database for complete collections of gene phylogenies

More...PhylomeDBi		O35552

TreeFam database of animal gene trees

More...TreeFami		TF313541

Family and domain databases

Conserved Domains Database

More...CDDi		cd07067 HP_PGM_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1240, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003094 6Pfruct_kin
IPR013079 6Phosfructo_kin
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR027417 P-loop_NTPase
IPR001345 PG/BPGM_mutase_AS

The PANTHER Classification System

More...PANTHERi		PTHR10606 PTHR10606, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01591 6PF2K, 1 hit
PF00300 His_Phos_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00991 6PFRUCTKNASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00855 PGAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit
SSF53254 SSF53254, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00175 PG_MUTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O35552-1) [UniParc]FASTAAdd to basket
Also known as: RB2K1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY 
        60         70         80         90        100
ISKKLTRYLN WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMRVRK 
       110        120        130        140        150
QCALAALRDV KSYLTKEGGQ IAVFDATNTT RERRHMILHF AKENDFKAFF 
       160        170        180        190        200
IESVCDDPTV VASNIMEVKI SSPDYKDCNS AEAMDDFMKR INCYEASYQP 
       210        220        230        240        250
LDPDKCDRDL SFIKVIDVGR RFLVNRVQDH IQSRIVYYLM NIHVQPRTIY 
       260        270        280        290        300
LCRHGENEYN VQGKIGGDSG LSSRGKKFAN ALSKFVEEQN LKDLRVWTSQ 
       310        320        330        340        350
LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ 
       360        370        380        390        400
DKYYYRYPTG ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL 
       410        420        430        440        450
DKSAEEMPYL KCPLHTVLKL TPVAYGCRVE SIYLNVESVS THRERSEAVK 
       460        470        480        490        500
IQHFASVVRP SSYTELDFLS VESAKQDAKK GPNPLMRRNS VTPLASPEPT 
       510        520        530        540        550
KKPRINSFEE HVASTSAALP SCLPPEVPTQ LPGQPLLGKA CLRTVCHIFS 

KFSPY
Length:555
Mass (Da):63,676
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45B2D090B44FCD8D
GO
Isoform 2 (identifier: O35552-2) [UniParc]FASTAAdd to basket
Also known as: RB2K2

The sequence of this isoform differs from the canonical sequence as follows:
     543-555: RTVCHIFSKFSPY → T

Show »
Length:543
Mass (Da):62,210
Checksum:iDA1B3F86851815D1
GO
Isoform 3 (identifier: O35552-3) [UniParc]FASTAAdd to basket
Also known as: RB2K3

The sequence of this isoform differs from the canonical sequence as follows:
     535-555: PLLGKACLRTVCHIFSKFSPY → NMRSPRSGAESSQKH

Show »
Length:549
Mass (Da):62,967
Checksum:i26E9DB0564825A82
GO
Isoform 4 (identifier: O35552-4) [UniParc]FASTAAdd to basket
Also known as: RB2K4

The sequence of this isoform differs from the canonical sequence as follows:
     448-476: Missing.

Show »
Length:526
Mass (Da):60,456
Checksum:iB41B90799C6003C9
GO
Isoform 5 (identifier: O35552-5) [UniParc]FASTAAdd to basket
Also known as: RB2K5

The sequence of this isoform differs from the canonical sequence as follows:
     448-476: Missing.
     543-555: RTVCHIFSKFSPY → T

Show »
Length:514
Mass (Da):58,991
Checksum:i6D3458ECED6716FC
GO
Isoform 6 (identifier: O35552-6) [UniParc]FASTAAdd to basket
Also known as: RB2K6

The sequence of this isoform differs from the canonical sequence as follows:
     448-476: Missing.
     535-555: PLLGKACLRTVCHIFSKFSPY → NMRSPRSGAESSQKH

Show »
Length:520
Mass (Da):59,747
Checksum:i78AD6CCDF66E1DAD
GO
Isoform 7 (identifier: O35552-7) [UniParc]FASTAAdd to basket
Also known as: RB2K7

The sequence of this isoform differs from the canonical sequence as follows:
     543-555: Missing.

Show »
Length:542
Mass (Da):62,109
Checksum:iCB3F86851815D1D7
GO
Isoform 8 (identifier: O35552-8) [UniParc]FASTAAdd to basket
Also known as: RB2K8

The sequence of this isoform differs from the canonical sequence as follows:
     448-476: Missing.
     543-555: Missing.

Show »
Length:513
Mass (Da):58,889
Checksum:i8458ECED6716FC15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7UAK3A7UAK3_RAT
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
462Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti185D → H in BAA22048 (Ref. 2) Curated1
Sequence conflicti367V → L in BAA22048 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004681448 – 476Missing in isoform 4, isoform 5, isoform 6 and isoform 8. CuratedAdd BLAST29
Alternative sequenceiVSP_004683535 – 555PLLGK…KFSPY → NMRSPRSGAESSQKH in isoform 3 and isoform 6. CuratedAdd BLAST21
Alternative sequenceiVSP_004682543 – 555RTVCH…KFSPY → T in isoform 2 and isoform 5. CuratedAdd BLAST13
Alternative sequenceiVSP_004684543 – 555Missing in isoform 7 and isoform 8. CuratedAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D87240 mRNA Translation: BAA21749.1
D87241 mRNA Translation: BAA21750.1
D87242 mRNA Translation: BAA21751.1
D87243 mRNA Translation: BAA21752.1
D87244 mRNA Translation: BAA21753.1
D87245 mRNA Translation: BAA21754.1
D87246 mRNA Translation: BAA21755.1
D87247 mRNA Translation: BAA21756.1
AB006710 mRNA Translation: BAA22048.1

NCBI Reference Sequences

More...RefSeqi		NP_476476.1, NM_057135.1 [O35552-1]
XP_006254254.1, XM_006254192.3 [O35552-3]
XP_006254255.1, XM_006254193.3 [O35552-2]
XP_006254258.1, XM_006254196.3 [O35552-4]
XP_006254259.1, XM_006254197.3 [O35552-6]
XP_006254260.1, XM_006254198.3 [O35552-5]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Rn.10791

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000025731; ENSRNOP00000025731; ENSRNOG00000018911 [O35552-8]
ENSRNOT00000051067; ENSRNOP00000040928; ENSRNOG00000018911 [O35552-2]
ENSRNOT00000068354; ENSRNOP00000062965; ENSRNOG00000018911 [O35552-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		117276

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:117276

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87240 mRNA Translation: BAA21749.1
D87241 mRNA Translation: BAA21750.1
D87242 mRNA Translation: BAA21751.1
D87243 mRNA Translation: BAA21752.1
D87244 mRNA Translation: BAA21753.1
D87245 mRNA Translation: BAA21754.1
D87246 mRNA Translation: BAA21755.1
D87247 mRNA Translation: BAA21756.1
AB006710 mRNA Translation: BAA22048.1
RefSeqiNP_476476.1, NM_057135.1 [O35552-1]
XP_006254254.1, XM_006254192.3 [O35552-3]
XP_006254255.1, XM_006254193.3 [O35552-2]
XP_006254258.1, XM_006254196.3 [O35552-4]
XP_006254259.1, XM_006254197.3 [O35552-6]
XP_006254260.1, XM_006254198.3 [O35552-5]
UniGeneiRn.10791

3D structure databases

ProteinModelPortaliO35552
SMRiO35552
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2043 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex
IntActiO35552, 2 interactors
STRINGi10116.ENSRNOP00000062965

PTM databases

iPTMnetiO35552
PhosphoSitePlusiO35552

Proteomic databases

PaxDbiO35552
PRIDEiO35552

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025731; ENSRNOP00000025731; ENSRNOG00000018911 [O35552-8]
ENSRNOT00000051067; ENSRNOP00000040928; ENSRNOG00000018911 [O35552-2]
ENSRNOT00000068354; ENSRNOP00000062965; ENSRNOG00000018911 [O35552-1]
GeneIDi117276
KEGGirno:117276

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5209
RGDi619776 Pfkfb3

Phylogenomic databases

eggNOGiKOG0234 Eukaryota
COG0406 LUCA
GeneTreeiENSGT00940000153570
HOVERGENiHBG005628
InParanoidiO35552
KOiK01103
OMAiHDSCEWL
OrthoDBiEOG091G0A43
PhylomeDBiO35552
TreeFamiTF313541

Enzyme and pathway databases

BRENDAi3.1.3.46 5301
ReactomeiR-RNO-70171 Glycolysis

Miscellaneous databases

Protein Ontology

More...PROi		PR:O35552

Gene expression databases

BgeeiENSRNOG00000018911 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiO35552 baseline and differential
GenevisibleiO35552 RN

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR003094 6Pfruct_kin
IPR013079 6Phosfructo_kin
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR027417 P-loop_NTPase
IPR001345 PG/BPGM_mutase_AS
PANTHERiPTHR10606 PTHR10606, 1 hit
PfamiView protein in Pfam
PF01591 6PF2K, 1 hit
PF00300 His_Phos_1, 1 hit
PRINTSiPR00991 6PFRUCTKNASE
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF263_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35552
Secondary accession number(s): O35096
, O35553, O35554, O35555, O35556, O35557, Q9QWQ5, Q9QWQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 1, 1998
Last modified: December 5, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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