Stx1a

Functionⁱ

Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca²⁺-regulation of exocytosis acrosomal reaction in sperm (PubMed:15774481).By similarity1 Publication

GO - Molecular functionⁱ

ATP-dependent protein binding Source: MGI
calcium channel inhibitor activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 10468580
calcium-dependent protein binding Source: MGI
chloride channel inhibitor activity Source: MGI
ion channel binding Source: MGI
kinase binding Source: MGI
myosin binding Source: MGI
myosin head/neck binding Source: MGI
protein binding, bridging Source: MGI
protein domain specific binding Source: MGI
protein heterodimerization activity Source: MGI
protein N-terminus binding Source: MGI
SNAP receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SNARE binding
Source: MGI
Inferred from direct assayⁱ
- 12145198

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion regulated exocytosis
Source: MGI
Inferred from mutant phenotypeⁱ
- 10468580
exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
modulation of excitatory postsynaptic potential Source: MGI
positive regulation of calcium ion-dependent exocytosis Source: UniProtKB
positive regulation of catecholamine secretion Source: UniProtKB
positive regulation of excitatory postsynaptic potential
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 24133272
positive regulation of exocytosis Source: MGI
positive regulation of neurotransmitter secretion
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 24133272
positive regulation of norepinephrine secretion Source: UniProtKB
protein localization to membrane Source: MGI
regulation of exocytosis Source: MGI
regulation of synaptic vesicle priming
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 24133272
response to gravity Source: MGI
secretion by cell Source: MGI
SNARE complex assembly Source: MGI
synaptic vesicle docking Source: Ensembl
synaptic vesicle exocytosis
Source: SynGO
Inferred from direct assayⁱ
- 27466336
synaptic vesicle fusion to presynaptic active zone membrane Source: MGI
vesicle docking
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle fusion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Exocytosis, Neurotransmitter transport, Transport

Biological process

Exocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-181429 Serotonin Neurotransmitter Release Cycle R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle R-MMU-210500 Glutamate Neurotransmitter Release Cycle R-MMU-212676 Dopamine Neurotransmitter Release Cycle R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle R-MMU-449836 Other interleukin signaling R-MMU-5682910 LGI-ADAM interactions R-MMU-888590 GABA synthesis, release, reuptake and degradation

Reactomeⁱ

R-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-449836 Other interleukin signaling
R-MMU-5682910 LGI-ADAM interactions
R-MMU-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syntaxin-1A Alternative name(s): Neuron-specific antigen HPC-1
Gene namesⁱ	Name:Stx1a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:109355 Stx1a

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 265	CytoplasmicSequence analysisAdd BLAST	265
Transmembraneⁱ	266 – 286	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	287 – 288	ExtracellularSequence analysis	2

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000210187	1 – 288	Syntaxin-1AAdd BLAST		288

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	14	PhosphoserineCombined sources	1
Modified residueⁱ	64	PhosphoserineCombined sources	1
Modified residueⁱ	95	PhosphoserineBy similarity	1
Modified residueⁱ	188	Phosphoserine; by DAPK1By similarity	1

Post-translational modificationⁱ

Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1 (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	O35526
PeptideAtlas More...PeptideAtlasⁱ	O35526
PRIDEⁱ	O35526

PTM databases

iPTMnetⁱ	O35526
PhosphoSitePlusⁱ	O35526
SwissPalmⁱ	O35526

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000007207 Expressed in 231 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_STX1A
ExpressionAtlasⁱ	O35526 baseline and differential
Genevisibleⁱ	O35526 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with KCNB1 (via C-terminus); the interaction increases in a calcium-dependent manner and induces a pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons (By similarity). Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A (By similarity). This complex binds to CPLX1 (By similarity). Interacts with VAPA and SYBU (By similarity). Binds STXBP6 (By similarity). Found in a complex with VAMP8 and SNAP23 (By similarity). Found in a ternary complex with STX1A and SNAP25 (By similarity). Interacts with SLC6A4 (By similarity). Binds SYTL4 (PubMed:12101244). Interacts with OTOF and LGI3 (PubMed:18760330, PubMed:17055430). Interacts with SYT6 and SYT8; the interaction is Ca²⁺-dependent (PubMed:15774481). Interacts with STXBP1 and DAPK1 (By similarity). Interacts with PLCL1 (via C2 domain) (PubMed:23341457). Interacts with PRRT2 (PubMed:29056747).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Sec22b	O08547	4	EBI-400878,EBI-8400083
Snap25	P60879	4	EBI-400878,EBI-445270
Syt1	P21707	3	EBI-400878,EBI-458098	From Rattus norvegicus.
Syt2	P46097	2	EBI-400878,EBI-457969
Syt7	Q62747	2	EBI-400878,EBI-16179541	From Rattus norvegicus.

GO - Molecular functionⁱ

ATP-dependent protein binding Source: MGI
calcium-dependent protein binding Source: MGI
ion channel binding Source: MGI
kinase binding Source: MGI
myosin binding Source: MGI
myosin head/neck binding Source: MGI
protein binding, bridging Source: MGI
protein domain specific binding Source: MGI
protein heterodimerization activity Source: MGI
protein N-terminus binding Source: MGI
SNAP receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SNARE binding
Source: MGI
Inferred from direct assayⁱ
- 12145198

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203561, 19 interactors
CORUMⁱ	O35526
Database of interacting proteins More...DIPⁱ	DIP-31950N
IntActⁱ	O35526, 22 interactors
Molecular INTeraction database More...MINTⁱ	O35526
STRINGⁱ	10090.ENSMUSP00000005509

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O35526
SMRⁱ	O35526
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	192 – 254	t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		63

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	68 – 109	Sequence analysisAdd BLAST		42

Sequence similaritiesⁱ

Belongs to the syntaxin family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0810 Eukaryota COG5074 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119200
HOGENOMⁱ	HOG000286023
HOVERGENⁱ	HBG000497
InParanoidⁱ	O35526
KEGG Orthology (KO) More...KOⁱ	K04560
OMAⁱ	FEEIDHI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EUK
PhylomeDBⁱ	O35526
TreeFamⁱ	TF313763

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00179 SynN, 1 hit
InterProⁱ	View protein in InterPro IPR010989 SNARE IPR028669 STX1A IPR006012 Syntaxin/epimorphin_CS IPR006011 Syntaxin_N IPR000727 T_SNARE_dom
PANTHERⁱ	PTHR19957:SF84 PTHR19957:SF84, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05739 SNARE, 1 hit PF00804 Syntaxin, 1 hit
SMARTⁱ	View protein in SMART SM00503 SynN, 1 hit SM00397 t_SNARE, 1 hit
SUPFAMⁱ	SSF47661 SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit PS50192 T_SNARE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O35526-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKDRTQELRT AKDSDDDDDV TVTVDRDRFM DEFFEQVEEI RGFIDKIAEN 
        60         70         80         90        100
VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI 
       110        120        130        140        150
EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ 
       160        170        180        190        200
RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS 
       210        220        230        240        250
EIIKLETSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD 
       260        270        280 
TKKAVKYQSK ARRKKIMIII CCVILGIIIA STIGGIFG

Length:288

Mass (Da):33,054

Last modified:December 19, 2001 - v3

Checksum:ⁱ8F8255F2EEF886CA

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RFB9	D6RFB9_MOUSE	Syntaxin-1A Syntaxin-1A	Stx1a	256	Annotation score:
A0A0J9YUA0	A0A0J9YUA0_MOUSE	Syntaxin-1A Syntaxin-1A	Stx1a	158	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D45208 mRNA Translation: BAA28865.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19731.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058081.2, NM_016801.4
UniGeneⁱ	Mm.6225

Genome annotation databases

Ensemblⁱ	ENSMUST00000005509; ENSMUSP00000005509; ENSMUSG00000007207
GeneIDⁱ	20907
KEGGⁱ	mmu:20907
UCSC genome browser More...UCSCⁱ	uc008zxk.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35526	Syntaxin 1A (Brain)		MOUSE		288	UniRef100_O35526
Stx1a protein (Fragment)		MOUSE		287

Protein	Similar proteins		Species	Score	Length	Source
O35526	Syntaxin-1A	)	RAT		288	UniRef90_P32851
Syntaxin-1A		BOVIN		288
Syntaxin-1A		PONAB		288
Syntaxin 1A (Brain)		MOUSE		288
Uncharacterized protein		Cebus capucinus imitator		288
+49

Protein	Similar proteins		Species	Score	Length	Source
O35526	Syntaxin-1A	)	RAT		288	UniRef50_P32851
Syntaxin-1A		BOVIN		288
Syntaxin-1A		PONAB		288
Syntaxin-1A		CAEBR		293
Syntaxin-1A homolog		CAEEL		291
+399

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D45208 mRNA Translation: BAA28865.2
CCDSⁱ	CCDS19731.1
RefSeqⁱ	NP_058081.2, NM_016801.4
UniGeneⁱ	Mm.6225

3D structure databases

ProteinModelPortalⁱ	O35526
SMRⁱ	O35526
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203561, 19 interactors
CORUMⁱ	O35526
DIPⁱ	DIP-31950N
IntActⁱ	O35526, 22 interactors
MINTⁱ	O35526
STRINGⁱ	10090.ENSMUSP00000005509

PTM databases

iPTMnetⁱ	O35526
PhosphoSitePlusⁱ	O35526
SwissPalmⁱ	O35526

Proteomic databases

PaxDbⁱ	O35526
PeptideAtlasⁱ	O35526
PRIDEⁱ	O35526

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000005509; ENSMUSP00000005509; ENSMUSG00000007207
GeneIDⁱ	20907
KEGGⁱ	mmu:20907
UCSCⁱ	uc008zxk.1 mouse

Organism-specific databases

CTDⁱ	6804
MGIⁱ	MGI:109355 Stx1a

Phylogenomic databases

eggNOGⁱ	KOG0810 Eukaryota COG5074 LUCA
GeneTreeⁱ	ENSGT00760000119200
HOGENOMⁱ	HOG000286023
HOVERGENⁱ	HBG000497
InParanoidⁱ	O35526
KOⁱ	K04560
OMAⁱ	FEEIDHI
OrthoDBⁱ	EOG091G0EUK
PhylomeDBⁱ	O35526
TreeFamⁱ	TF313763

Enzyme and pathway databases

Reactomeⁱ	R-MMU-181429 Serotonin Neurotransmitter Release Cycle R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle R-MMU-210500 Glutamate Neurotransmitter Release Cycle R-MMU-212676 Dopamine Neurotransmitter Release Cycle R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle R-MMU-449836 Other interleukin signaling R-MMU-5682910 LGI-ADAM interactions R-MMU-888590 GABA synthesis, release, reuptake and degradation

Reactomeⁱ

R-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-449836 Other interleukin signaling
R-MMU-5682910 LGI-ADAM interactions
R-MMU-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O35526
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000007207 Expressed in 231 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_STX1A
ExpressionAtlasⁱ	O35526 baseline and differential
Genevisibleⁱ	O35526 MM

Family and domain databases

CDDⁱ	cd00179 SynN, 1 hit
InterProⁱ	View protein in InterPro IPR010989 SNARE IPR028669 STX1A IPR006012 Syntaxin/epimorphin_CS IPR006011 Syntaxin_N IPR000727 T_SNARE_dom
PANTHERⁱ	PTHR19957:SF84 PTHR19957:SF84, 1 hit
Pfamⁱ	View protein in Pfam PF05739 SNARE, 1 hit PF00804 Syntaxin, 1 hit
SMARTⁱ	View protein in SMART SM00503 SynN, 1 hit SM00397 t_SNARE, 1 hit
SUPFAMⁱ	SSF47661 SSF47661, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit PS50192 T_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STX1A_MOUSE
Accessionⁱ	O35526Primary (citable) accession number: O35526
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	December 19, 2001
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O35526 (STX1A_MOUSE)

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Syntaxin-1A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ