Peroxisome proliferator-activated receptor alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
• lipid binding Source: UniProtKB
• nuclear receptor activity Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
• RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
• steroid hormone receptor activity Source: Ensembl
• ubiquitin conjugating enzyme binding Source: Ensembl
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• cellular response to starvation Source: Ensembl
• circadian regulation of gene expression Source: UniProtKB
• enamel mineralization Source: Ensembl
• epidermis development Source: Ensembl
• fatty acid metabolic process Source: Ensembl
• negative regulation of appetite Source: UniProtKB
• negative regulation of cholesterol storage Source: Ensembl
• negative regulation of cytokine production involved in inflammatory response Source: Ensembl
• negative regulation of glycolytic process Source: Ensembl
• negative regulation of hepatocyte apoptotic process Source: Ensembl
• negative regulation of inflammatory response Source: Ensembl
• negative regulation of leukocyte cell-cell adhesion Source: Ensembl
• negative regulation of macrophage derived foam cell differentiation Source: Ensembl
• negative regulation of miRNA transcription Source: Ensembl
• negative regulation of protein kinase B signaling Source: Ensembl
• negative regulation of reactive oxygen species biosynthetic process Source: Ensembl
• negative regulation of sequestering of triglyceride Source: Ensembl
• negative regulation of signaling receptor activity Source: Ensembl
• negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
• positive regulation of ATP biosynthetic process Source: Ensembl
• positive regulation of fatty acid oxidation Source: Ensembl
• positive regulation of gluconeogenesis Source: Ensembl
• positive regulation of lipid biosynthetic process Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of viral genome replication Source: Ensembl
• regulation of circadian rhythm Source: UniProtKB
• wound healing Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
• ubiquitin conjugating enzyme binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVDMESPLCP LSPLEAEDLE SPLSEYFLQE MGTIQDISRS LGEDSSGSFG 
        60         70         80         90        100
FPEYQYLGSG PGSDGSVITD TLSPASSPSS VSYPEVPCGV DEPPSSALNI 
       110        120        130        140        150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR 
       160        170        180        190        200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEVLT CDRDSEGAET 
       210        220        230        240        250
ADLKSLAKRI YEAYLKNFHM NKVKARIILA GKTSSHPLFV IHDMETLCTA 
       260        270        280        290        300
EKTLMAKVVS DGIRDKEAEV RIFHCCQCVS VETVTNLTEF AKAIPGFASL 
       310        320        330        340        350
DLNDQVTLLK YGVYEAIFTM LSSTMNKDGM LVAYGHGFIT REFLKNLRKP 
       360        370        380        390        400
FCDMMEPKFN FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIDHIEKM 
       410        420        430        440        450
QEAIVHVLKL HLQSNHPDDT FLFPKLLQKL ADLRQLVTEH AQLVQVIKTE 
       460 
SDAALHPLLQ EIYRDMY                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families