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Protein

Gamma-crystallin S

Gene

Crygs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: MGI

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin S
Alternative name(s):
Beta-crystallin S
Gamma-S-crystallin
Gene namesi
Name:Crygs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1298216 Crygs

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000575662 – 178Gamma-crystallin SAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO35486
PRIDEiO35486

PTM databases

PhosphoSitePlusiO35486

Expressioni

Gene expression databases

BgeeiENSMUSG00000033501 Expressed in 49 organ(s), highest expression level in eyeball of camera-type eye
CleanExiMM_CRYGS
ExpressionAtlasiO35486 baseline and differential
GenevisibleiO35486 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043588

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO35486
SMRiO35486
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35486

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 44Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini45 – 87Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini94 – 134Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini135 – 177Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 5N-terminal arm4
Regioni88 – 93Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEJ7 Eukaryota
ENOG4111EVU LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiO35486
OMAiHWMGLND
OrthoDBiEOG091G0L2P
PhylomeDBiO35486

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35486-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKTGGKISF YEDRNFQGRR YDCDCDCADF RSYLSRCNSI RVEGGTWAVY
60 70 80 90 100
ERPNFSGHMY ILPQGEYPEY QRWMGLNDRL GSCRAVHLSS GGQAKIQVFE
110 120 130 140 150
KGDFNGQMYE TTEDCPSIME QFHLREIHSC KVVEGTWIFY ELPNYRGRQY
160 170
LLDKKEYRKP VDWGAASPAI QSFRRIVE
Length:178
Mass (Da):20,850
Last modified:January 23, 2007 - v3
Checksum:i40AD1B4835A87C4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032995 mRNA Translation: AAC53579.1
AF055703, AF055702 Genomic DNA Translation: AAC40120.1
BC056452 mRNA Translation: AAH56452.1
CCDSiCCDS28069.1
RefSeqiNP_034097.1, NM_009967.2
UniGeneiMm.6253

Genome annotation databases

EnsembliENSMUST00000040592; ENSMUSP00000043588; ENSMUSG00000033501
GeneIDi12970
KEGGimmu:12970
UCSCiuc007ysj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032995 mRNA Translation: AAC53579.1
AF055703, AF055702 Genomic DNA Translation: AAC40120.1
BC056452 mRNA Translation: AAH56452.1
CCDSiCCDS28069.1
RefSeqiNP_034097.1, NM_009967.2
UniGeneiMm.6253

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZWMNMR-A2-178[»]
1ZWONMR-A2-178[»]
2A5MNMR-A2-178[»]
ProteinModelPortaliO35486
SMRiO35486
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043588

PTM databases

PhosphoSitePlusiO35486

Proteomic databases

PaxDbiO35486
PRIDEiO35486

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040592; ENSMUSP00000043588; ENSMUSG00000033501
GeneIDi12970
KEGGimmu:12970
UCSCiuc007ysj.2 mouse

Organism-specific databases

CTDi1427
MGIiMGI:1298216 Crygs

Phylogenomic databases

eggNOGiENOG410IEJ7 Eukaryota
ENOG4111EVU LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiO35486
OMAiHWMGLND
OrthoDBiEOG091G0L2P
PhylomeDBiO35486

Miscellaneous databases

EvolutionaryTraceiO35486
PROiPR:O35486
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033501 Expressed in 49 organ(s), highest expression level in eyeball of camera-type eye
CleanExiMM_CRYGS
ExpressionAtlasiO35486 baseline and differential
GenevisibleiO35486 MM

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRYGS_MOUSE
AccessioniPrimary (citable) accession number: O35486
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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