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Protein

Antizyme inhibitor 1

Gene

Azin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:16916800, PubMed:18062773, PubMed:18508777). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:10698696, PubMed:18062773, PubMed:18369191).5 Publications

GO - Molecular functioni

  • ornithine decarboxylase activator activity Source: MGI
  • ornithine decarboxylase activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processPolyamine biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-350562 Regulation of ornithine decarboxylase (ODC)

Names & Taxonomyi

Protein namesi
Recommended name:
Antizyme inhibitor 1
Short name:
AZI
Alternative name(s):
Ornithine decarboxylase antizyme inhibitor
Gene namesi
Name:Azin1
Synonyms:Oazi, Oazin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1859169 Azin1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499931 – 448Antizyme inhibitor 1Add BLAST448

Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69Not modifiedCombined sources1 Publication1

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiO35484
PRIDEiO35484

PTM databases

iPTMnetiO35484
PhosphoSitePlusiO35484

Expressioni

Tissue specificityi

Expressed during testis development.2 Publications

Gene expression databases

BgeeiENSMUSG00000037458 Expressed in 284 organ(s), highest expression level in morula
CleanExiMM_AZIN1
ExpressionAtlasiO35484 baseline and differential
GenevisibleiO35484 MM

Interactioni

Subunit structurei

Monomer (PubMed:18369191). Interacts with OAZ1 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:18062773, PubMed:18369191).2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065544

Structurei

Secondary structure

1448
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO35484
SMRiO35484
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35484

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
HOGENOMiHOG000274133
HOVERGENiHBG005456
InParanoidiO35484
OMAiVFCRILC
OrthoDBiEOG091G0AJV
PhylomeDBiO35484
TreeFamiTF300760

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031178 Azin1
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482 PTHR11482, 1 hit
PTHR11482:SF7 PTHR11482:SF7, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O35484-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK
60 70 80 90 100
KHSQWQTVVA QIKPFYTVKC NSTPAVLEIL AALGTGFACS SKNEMALVQE
110 120 130 140 150
LGVSPENIIF TSPCKQVSQI KYAAKVGVNI MTCDNEIELK KIARNHPNAK
160 170 180 190 200
VLLHIATEDN IGGEDGNMKF GTTLKNCRHL LECAKELDVQ IIGVKFHVSS
210 220 230 240 250
ACKEYQVYVH ALSDARCVFD MAGEFGFTMN MLDIGGGFTG TEIQLEEVNH
260 270 280 290 300
VISPLLDIYF PEGSGIQIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFSS
310 320 330 340 350
GVEKNGSDEP AFVYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT
360 370 380 390 400
SSLWGPSCDE LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR
410 420 430 440
PAIYFMMSFS DWYEMQDAGI TSDAMMKNFF FAPSCIQLSQ EDSFSTEA
Length:448
Mass (Da):49,549
Last modified:January 1, 1998 - v1
Checksum:i117F3C2C24DDCA0F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2P3D3Z2P3_MOUSE
Antizyme inhibitor 1
Azin1
149Annotation score:
D6RE45D6RE45_MOUSE
Antizyme inhibitor 1
Azin1
154Annotation score:
D3YW58D3YW58_MOUSE
Antizyme inhibitor 1
Azin1
132Annotation score:
D3YUY1D3YUY1_MOUSE
Antizyme inhibitor 1
Azin1
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36G → E in AAH19412 (PubMed:15489334).Curated1
Sequence conflicti367S → G in BAC40151 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032128 mRNA Translation: AAB87464.1
AK049680 mRNA Translation: BAC33870.1
AK088112 mRNA Translation: BAC40151.1
AK088671 mRNA Translation: BAC40494.1
BC019412 mRNA Translation: AAH19412.1
BC043722 mRNA Translation: AAH43722.1
CCDSiCCDS37065.1
RefSeqiNP_001095928.1, NM_001102458.1
NP_001288617.1, NM_001301688.1
NP_061215.1, NM_018745.5
UniGeneiMm.250214

Genome annotation databases

EnsembliENSMUST00000065308; ENSMUSP00000065544; ENSMUSG00000037458
ENSMUST00000110329; ENSMUSP00000105958; ENSMUSG00000037458
GeneIDi54375
KEGGimmu:54375
UCSCiuc007vns.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032128 mRNA Translation: AAB87464.1
AK049680 mRNA Translation: BAC33870.1
AK088112 mRNA Translation: BAC40151.1
AK088671 mRNA Translation: BAC40494.1
BC019412 mRNA Translation: AAH19412.1
BC043722 mRNA Translation: AAH43722.1
CCDSiCCDS37065.1
RefSeqiNP_001095928.1, NM_001102458.1
NP_001288617.1, NM_001301688.1
NP_061215.1, NM_018745.5
UniGeneiMm.250214

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BTNX-ray2.05A/B1-448[»]
ProteinModelPortaliO35484
SMRiO35484
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065544

PTM databases

iPTMnetiO35484
PhosphoSitePlusiO35484

Proteomic databases

PaxDbiO35484
PRIDEiO35484

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065308; ENSMUSP00000065544; ENSMUSG00000037458
ENSMUST00000110329; ENSMUSP00000105958; ENSMUSG00000037458
GeneIDi54375
KEGGimmu:54375
UCSCiuc007vns.1 mouse

Organism-specific databases

CTDi51582
MGIiMGI:1859169 Azin1

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
HOGENOMiHOG000274133
HOVERGENiHBG005456
InParanoidiO35484
OMAiVFCRILC
OrthoDBiEOG091G0AJV
PhylomeDBiO35484
TreeFamiTF300760

Enzyme and pathway databases

ReactomeiR-MMU-350562 Regulation of ornithine decarboxylase (ODC)

Miscellaneous databases

ChiTaRSiAzin1 mouse
EvolutionaryTraceiO35484
PROiPR:O35484
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037458 Expressed in 284 organ(s), highest expression level in morula
CleanExiMM_AZIN1
ExpressionAtlasiO35484 baseline and differential
GenevisibleiO35484 MM

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031178 Azin1
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482 PTHR11482, 1 hit
PTHR11482:SF7 PTHR11482:SF7, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAZIN1_MOUSE
AccessioniPrimary (citable) accession number: O35484
Secondary accession number(s): Q542G5, Q8C2R8, Q8K1E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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