Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear nucleic acid-binding protein C1D

Gene

C1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor, RNA-binding
Biological processApoptosis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear nucleic acid-binding protein C1D
Short name:
mC1D
Alternative name(s):
Small unique nuclear receptor corepressor
Short name:
Sun-CoR
Short name:
SunCoR
Gene namesi
Name:C1d
Synonyms:Suncor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1927354 C1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003163011 – 141Nuclear nucleic acid-binding protein C1DAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated by PRKDC.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO35473
PaxDbiO35473
PeptideAtlasiO35473
PRIDEiO35473

PTM databases

iPTMnetiO35473
PhosphoSitePlusiO35473

Expressioni

Tissue specificityi

Kidney, heart, brain, spleen, lung, testis, liver and small intestine.1 Publication

Inductioni

Up-regulated during adipocyte and myogenic differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000000581 Expressed in 292 organ(s), highest expression level in pharyngeal arch 2
CleanExiMM_C1D
ExpressionAtlasiO35473 baseline and differential
GenevisibleiO35473 MM

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3 (By similarity). Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000594

Structurei

3D structure databases

ProteinModelPortaliO35473
SMRiO35473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 100Required for transcriptional repressionAdd BLAST100
Regioni50 – 100Interaction with NR1D11 PublicationAdd BLAST51
Regioni100 – 141Interaction with NCOR1 and NCOR21 PublicationAdd BLAST42

Sequence similaritiesi

Belongs to the C1D family.Curated

Phylogenomic databases

eggNOGiKOG4835 Eukaryota
ENOG4111ZX6 LUCA
GeneTreeiENSGT00390000015405
HOGENOMiHOG000007644
HOVERGENiHBG097935
InParanoidiO35473
KOiK12592
OMAiIRTYMNK
OrthoDBiEOG091G0YK9
PhylomeDBiO35473
TreeFamiTF314651

Family and domain databases

InterProiView protein in InterPro
IPR011082 Exosome-assoc_fac/DNA_repair
IPR007146 Sas10/Utp3/C1D
PANTHERiPTHR15341 PTHR15341, 1 hit
PfamiView protein in Pfam
PF04000 Sas10_Utp3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35473-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGEEMNEDY PVEIHESLTA LESSLGAVDD MLKTMMAVSR NELLQKLDPL
60 70 80 90 100
EQAKVDLVSA YTLNSMFWVY LATQGVNPKE HPVKQELERI RVYMNRVKEI
110 120 130 140
TDKKKAAKLD RGAASRFVKN ALWEPKAKST PKVANKGKSK H
Length:141
Mass (Da):15,945
Last modified:January 1, 1998 - v1
Checksum:iC9AF68033A0FD04E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQK7A0A0A0MQK7_MOUSE
Nuclear nucleic acid-binding protei...
C1d
118Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120N → K in CAA64844 (PubMed:9469821).Curated1
Sequence conflicti127A → R in CAA64844 (PubMed:9469821).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031426 Genomic DNA Translation: AAC53520.1
X95591 mRNA Translation: CAA64844.1
AK028702 mRNA Translation: BAC26075.1
AK035169 mRNA Translation: BAC28967.1
AL603925 Genomic DNA Translation: CAI24257.1
AL603925 Genomic DNA Translation: CAI24258.1
BC005436 mRNA Translation: AAH05436.1
CCDSiCCDS24451.1
RefSeqiNP_001317578.1, NM_001330649.1
NP_065583.2, NM_020558.4
UniGeneiMm.287982

Genome annotation databases

EnsembliENSMUST00000000594; ENSMUSP00000000594; ENSMUSG00000000581
GeneIDi57316
KEGGimmu:57316
UCSCiuc007ice.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031426 Genomic DNA Translation: AAC53520.1
X95591 mRNA Translation: CAA64844.1
AK028702 mRNA Translation: BAC26075.1
AK035169 mRNA Translation: BAC28967.1
AL603925 Genomic DNA Translation: CAI24257.1
AL603925 Genomic DNA Translation: CAI24258.1
BC005436 mRNA Translation: AAH05436.1
CCDSiCCDS24451.1
RefSeqiNP_001317578.1, NM_001330649.1
NP_065583.2, NM_020558.4
UniGeneiMm.287982

3D structure databases

ProteinModelPortaliO35473
SMRiO35473
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000594

PTM databases

iPTMnetiO35473
PhosphoSitePlusiO35473

Proteomic databases

MaxQBiO35473
PaxDbiO35473
PeptideAtlasiO35473
PRIDEiO35473

Protocols and materials databases

DNASUi57316
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000594; ENSMUSP00000000594; ENSMUSG00000000581
GeneIDi57316
KEGGimmu:57316
UCSCiuc007ice.1 mouse

Organism-specific databases

CTDi10438
MGIiMGI:1927354 C1d

Phylogenomic databases

eggNOGiKOG4835 Eukaryota
ENOG4111ZX6 LUCA
GeneTreeiENSGT00390000015405
HOGENOMiHOG000007644
HOVERGENiHBG097935
InParanoidiO35473
KOiK12592
OMAiIRTYMNK
OrthoDBiEOG091G0YK9
PhylomeDBiO35473
TreeFamiTF314651

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:O35473
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000581 Expressed in 292 organ(s), highest expression level in pharyngeal arch 2
CleanExiMM_C1D
ExpressionAtlasiO35473 baseline and differential
GenevisibleiO35473 MM

Family and domain databases

InterProiView protein in InterPro
IPR011082 Exosome-assoc_fac/DNA_repair
IPR007146 Sas10/Utp3/C1D
PANTHERiPTHR15341 PTHR15341, 1 hit
PfamiView protein in Pfam
PF04000 Sas10_Utp3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC1D_MOUSE
AccessioniPrimary (citable) accession number: O35473
Secondary accession number(s): Q5SWJ6, Q61368
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again