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Protein

Protein Wnt-9b

Gene

Wnt9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:22461561). Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (PubMed:22461561, PubMed:25257647).Curated2 Publications

GO - Molecular functioni

  • co-receptor binding Source: ParkinsonsUK-UCL
  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: MGI
  • signaling receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9b
Alternative name(s):
Protein Wnt-14b1 Publication
Protein Wnt-15
Gene namesi
Name:Wnt9b
Synonyms:Wnt14b1 Publication, Wnt15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1197020 Wnt9b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Spontaneous insertion of a retrotransposon in the Wnt9b promoter region causes reduced Wnt9b expression. Decreased Wnt9b expression is correlated with increased incidence of cleft lip and palate.1 Publication

Disruption phenotypei

All mutant embryos have a cleft lip and palate phenotype at 18.5 dpc, plus additional, bilateral defects in upper jaw skeleton development. Embryos appear normal at 10.5 dpc, but display hypoplasia of the lateral and medial nasal process at 11 dpc. At 11.5 dpc, they display a clear bilateral gap between the medial nasal process and the fused medial end of the lateral nasal process and the maxillary process. The palatal shelves display lack of midline contact at 14.5 dpc.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004145924 – 359Protein Wnt-9bAdd BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi91 ↔ 102By similarity
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 145By similarity
Disulfide bondi147 ↔ 164By similarity
Disulfide bondi212 ↔ 226By similarity
Disulfide bondi214 ↔ 221By similarity
Lipidationi218O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi307 ↔ 318By similarity
Disulfide bondi333 ↔ 348By similarity
Disulfide bondi335 ↔ 345By similarity
Disulfide bondi340 ↔ 341By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiO35468
PRIDEiO35468

PTM databases

PhosphoSitePlusiO35468

Expressioni

Developmental stagei

Detected in embryonic head from early headfold stages to at least 12 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000018486 Expressed in 92 organ(s), highest expression level in interventricular septum
CleanExiMM_WNT9B
ExpressionAtlasiO35468 baseline and differential
GenevisibleiO35468 MM

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59409N
IntActiO35468, 2 interactors
MINTiO35468
STRINGi10090.ENSMUSP00000018630

Structurei

3D structure databases

ProteinModelPortaliO35468
SMRiO35468
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00690000101857
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiO35468
KOiK01064
OMAiCAKDTSC
OrthoDBiEOG091G0OFF
PhylomeDBiO35468
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026535 WNT9B
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF84 PTHR12027:SF84, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35468-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPAPALALA ALCLLVLPAA AAAAAYFGLT GREVLTPFPG LGTAAAPAQA
60 70 80 90 100
GAHLKQCDLL KLSRRQKQLC RREPGLAETL RDAAHLGLLE CQFQFRQERW
110 120 130 140 150
NCSLEGRTGL LQRGFKETAF LYAVSAAALT HALARACSAG RMERCTCDDS
160 170 180 190 200
PGLESRQAWQ WGVCGDNLKY STKFLSNFLG PKRGSKDLRA RADAHNTHVG
210 220 230 240 250
IKAVKSGLRT TCKCHGVSGS CAVRTCWKQL SPFRETGQVL KLRYDTAVKV
260 270 280 290 300
SSATNEALGR LELWAPAKPG GPAKGLAPRP GDLVYMEDSP SFCRPSKYSP
310 320 330 340 350
GTAGRVCSRD SSCSSLCCGR GYDTQSRMVV FSCHCQVQWC CYVECQQCAQ

QELVYTCKR
Length:359
Mass (Da):38,982
Last modified:April 30, 2003 - v2
Checksum:iC98D7B5F566B70F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310D → G in AAC39950 (PubMed:9441749).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073819 mRNA Translation: BAB83866.1
AF469004 mRNA Translation: AAL82385.1
AF031169 Genomic DNA Translation: AAC39950.1
CCDSiCCDS25522.1
RefSeqiNP_035849.3, NM_011719.4
UniGeneiMm.215161

Genome annotation databases

EnsembliENSMUST00000018630; ENSMUSP00000018630; ENSMUSG00000018486
GeneIDi22412
KEGGimmu:22412
UCSCiuc007lvr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073819 mRNA Translation: BAB83866.1
AF469004 mRNA Translation: AAL82385.1
AF031169 Genomic DNA Translation: AAC39950.1
CCDSiCCDS25522.1
RefSeqiNP_035849.3, NM_011719.4
UniGeneiMm.215161

3D structure databases

ProteinModelPortaliO35468
SMRiO35468
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59409N
IntActiO35468, 2 interactors
MINTiO35468
STRINGi10090.ENSMUSP00000018630

PTM databases

PhosphoSitePlusiO35468

Proteomic databases

PaxDbiO35468
PRIDEiO35468

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018630; ENSMUSP00000018630; ENSMUSG00000018486
GeneIDi22412
KEGGimmu:22412
UCSCiuc007lvr.1 mouse

Organism-specific databases

CTDi7484
MGIiMGI:1197020 Wnt9b

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00690000101857
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiO35468
KOiK01064
OMAiCAKDTSC
OrthoDBiEOG091G0OFF
PhylomeDBiO35468
TreeFamiTF105310

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Miscellaneous databases

PROiPR:O35468
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018486 Expressed in 92 organ(s), highest expression level in interventricular septum
CleanExiMM_WNT9B
ExpressionAtlasiO35468 baseline and differential
GenevisibleiO35468 MM

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026535 WNT9B
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF84 PTHR12027:SF84, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWNT9B_MOUSE
AccessioniPrimary (citable) accession number: O35468
Secondary accession number(s): Q8VI90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 30, 2003
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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