UniProtKB - O35462 (ANGP2_RAT)
Angiopoietin-2
Angpt2
Functioni
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 429 | CalciumBy similarity | 1 | |
Metal bindingi | 431 | CalciumBy similarity | 1 | |
Metal bindingi | 433 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 435 | Calcium; via carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- receptor tyrosine kinase binding Source: RGD
- signaling receptor binding Source: GO_Central
GO - Biological processi
- angiogenesis Source: RGD
- animal organ regeneration Source: RGD
- blood vessel morphogenesis Source: RGD
- cellular response to growth factor stimulus Source: RGD
- gene expression Source: RGD
- germ cell development Source: RGD
- glomerulus vasculature development Source: UniProtKB
- maternal process involved in female pregnancy Source: RGD
- negative regulation of angiogenesis Source: RGD
- negative regulation of blood vessel endothelial cell migration Source: RGD
- negative regulation of cell-substrate adhesion Source: RGD
- negative regulation of positive chemotaxis Source: RGD
- positive regulation of angiogenesis Source: RGD
- response to activity Source: RGD
- response to glucose Source: RGD
- response to hypoxia Source: RGD
- response to mechanical stimulus Source: RGD
- response to organic cyclic compound Source: RGD
- response to radiation Source: RGD
- Tie signaling pathway Source: RGD
Keywordsi
Molecular function | Developmental protein |
Biological process | Angiogenesis, Differentiation |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-RNO-210993, Tie2 Signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Angiopoietin-2Short name: ANG-2 |
Gene namesi | Name:Angpt2 Synonyms:Agpt2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621861, Angpt2 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: RGD
Nucleus
- nucleus Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cell projection Source: RGD
- collagen-containing extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000099064 | 19 – 496 | Angiopoietin-2Add BLAST | 478 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 133 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 240 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 284 ↔ 313 | PROSITE-ProRule annotation | ||
Glycosylationi | 304 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 433 ↔ 435 | PROSITE-ProRule annotation | ||
Disulfide bondi | 437 ↔ 450 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O35462 |
PTM databases
GlyGeni | O35462, 6 sites |
iPTMneti | O35462 |
PhosphoSitePlusi | O35462 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000016696, Expressed in quadriceps femoris and 22 other tissues |
Genevisiblei | O35462, RN |
Interactioni
Subunit structurei
Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.
Interacts with ITGA5.
By similarityGO - Molecular functioni
- receptor tyrosine kinase binding Source: RGD
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000022774 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 280 – 496 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 217 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 159 – 256 | Sequence analysisAdd BLAST | 98 |
Domaini
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000158430 |
HOGENOMi | CLU_038628_3_1_1 |
InParanoidi | O35462 |
OMAi | KIQLKDW |
OrthoDBi | 357340at2759 |
PhylomeDBi | O35462 |
TreeFami | TF336658 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit |
InterProi | View protein in InterPro IPR028844, Ang-2 IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR002181, Fibrinogen_a/b/g_C_dom IPR020837, Fibrinogen_CS |
PANTHERi | PTHR19143:SF199, PTHR19143:SF199, 1 hit |
Pfami | View protein in Pfam PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MWQIVFLTFG CDLVLASAYN NFRKSVDSTG RRQYQVQNGP CSYTFLLPET
60 70 80 90 100
DSCRSSSSPY MSNAVQRDAP LDYDDSVQRL QVLENILENN TQWLMKLENY
110 120 130 140 150
IQDNMKKEMV EIQQNVVQNQ TAVMIEIGTS LLNQTAAQTR KLTDVEAQVL
160 170 180 190 200
NQTTRLELQL LQHSISTNKL EKQILDQTSE INKLQDKNSF LEKKVLDMED
210 220 230 240 250
KHSVQLQSMK EQKDQLQVLV SKQSSVIDEL EKKLVTATVN NSVLQKQQHD
260 270 280 290 300
LMETVNSLLT MMSSPDYKSS VAVPKEEKTT FRDCAEIFKS GLTTSGIYTL
310 320 330 340 350
TFPNSTEEVK AYCDMDMGGG GWTVIQHRED GSVDFQRTWK EYKEGFGSPL
360 370 380 390 400
GEYWLGNEFV SQLTSGHRYV LKIQLKDWEG SEAHSLYEHF YLSGEESNYR
410 420 430 440 450
IHLTGLTGTA GKISSISQPG SDFSTKDSDN DKCICKCSQM LTGGWWFDAC
460 470 480 490
GPSNLNGQYY PQKQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473970 Genomic DNA Translation: EDM08957.1 BC161931 mRNA Translation: AAI61931.1 AF030378 mRNA Translation: AAC78247.1 AF311728 mRNA Translation: AAG34114.1 |
RefSeqi | NP_604449.1, NM_134454.1 |
Genome annotation databases
Ensembli | ENSRNOT00000022774; ENSRNOP00000022774; ENSRNOG00000016696 |
GeneIDi | 89805 |
KEGGi | rno:89805 |
UCSCi | RGD:621861, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473970 Genomic DNA Translation: EDM08957.1 BC161931 mRNA Translation: AAI61931.1 AF030378 mRNA Translation: AAC78247.1 AF311728 mRNA Translation: AAG34114.1 |
RefSeqi | NP_604449.1, NM_134454.1 |
3D structure databases
AlphaFoldDBi | O35462 |
SMRi | O35462 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000022774 |
PTM databases
GlyGeni | O35462, 6 sites |
iPTMneti | O35462 |
PhosphoSitePlusi | O35462 |
Proteomic databases
PaxDbi | O35462 |
Genome annotation databases
Ensembli | ENSRNOT00000022774; ENSRNOP00000022774; ENSRNOG00000016696 |
GeneIDi | 89805 |
KEGGi | rno:89805 |
UCSCi | RGD:621861, rat |
Organism-specific databases
CTDi | 285 |
RGDi | 621861, Angpt2 |
Phylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000158430 |
HOGENOMi | CLU_038628_3_1_1 |
InParanoidi | O35462 |
OMAi | KIQLKDW |
OrthoDBi | 357340at2759 |
PhylomeDBi | O35462 |
TreeFami | TF336658 |
Enzyme and pathway databases
Reactomei | R-RNO-210993, Tie2 Signaling |
Miscellaneous databases
PROi | PR:O35462 |
Gene expression databases
Bgeei | ENSRNOG00000016696, Expressed in quadriceps femoris and 22 other tissues |
Genevisiblei | O35462, RN |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit |
InterProi | View protein in InterPro IPR028844, Ang-2 IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR002181, Fibrinogen_a/b/g_C_dom IPR020837, Fibrinogen_CS |
PANTHERi | PTHR19143:SF199, PTHR19143:SF199, 1 hit |
Pfami | View protein in Pfam PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ANGP2_RAT | |
Accessioni | O35462Primary (citable) accession number: O35462 Secondary accession number(s): B1WBY0, Q548N5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | March 24, 2009 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |