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Protein

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

Gene

Ech1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.By similarity

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei173Substrate; via amide nitrogenBy similarity1
Sitei196Important for catalytic activityBy similarity1
Sitei204Important for catalytic activityBy similarity1

GO - Molecular functioni

  • delta3,5-delta2,4-dienoyl-CoA isomerase activity Source: GO_Central
  • signaling receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-9033241 Peroxisomal protein import
UniPathwayi
UPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC:5.3.3.-)
Gene namesi
Name:Ech1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1858208 Ech1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000000741834 – 327Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrialAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147N6-acetyllysineCombined sources1
Modified residuei230N6-succinyllysineCombined sources1
Modified residuei267PhosphoserineBy similarity1
Modified residuei316N6-succinyllysineCombined sources1
Modified residuei326N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35459
MaxQBiO35459
PaxDbiO35459
PeptideAtlasiO35459
PRIDEiO35459

2D gel databases

REPRODUCTION-2DPAGEiO35459

PTM databases

iPTMnetiO35459
PhosphoSitePlusiO35459
SwissPalmiO35459

Expressioni

Gene expression databases

BgeeiENSMUSG00000053898 Expressed in 293 organ(s), highest expression level in brown adipose tissue
CleanExiMM_ECH1
ExpressionAtlasiO35459 baseline and differential
GenevisibleiO35459 MM

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206181, 1 interactor
IntActiO35459, 4 interactors
MINTiO35459
STRINGi10090.ENSMUSP00000066092

Structurei

3D structure databases

ProteinModelPortaliO35459
SMRiO35459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 119Substrate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi325 – 327Microbody targeting signalSequence analysis3

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1681 Eukaryota
ENOG410XTHX LUCA
GeneTreeiENSGT00890000139344
HOGENOMiHOG000027939
HOVERGENiHBG005556
InParanoidiO35459
KOiK12663
OMAiHKACIGA
OrthoDBiEOG091G0H26
PhylomeDBiO35459
TreeFamiTF314317

Family and domain databases

Gene3Di1.10.12.10, 1 hit
InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 Enoyl-CoA_hydra_C
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35459-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAMTVSSK LRGLLMQQLR GTSQLYFNIS LRSLSSSAQE ASKRAPEEVS
60 70 80 90 100
DHNYESIQVT SAQKHVLHVQ LNRPEKRNAM NRAFWRELVE CFQKISKDSD
110 120 130 140 150
CRAVVVSGAG KMFTSGIDLM DMASELMQPS GDDAARIAWY LRDLISKYQK
160 170 180 190 200
TFTVIEKCPK PVIAAIHGGC IGGGVDLVSA CDIRYCTQDA FFQIKEVDMG
210 220 230 240 250
LAADVGTLQR LPKVIGNQSL VNELTFSARK MMADEALDSG LVSRVFQDKD
260 270 280 290 300
AMLNAAFALA ADISSKSPVA VQGSKINLIY SRDHSVDESL DYMATWNMSM
310 320
LQTQDIIKSV QAAMEKRDTK SITFSKL
Length:327
Mass (Da):36,118
Last modified:January 1, 1998 - v1
Checksum:iCC0E612C74FBEE2E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7B227F7B227_MOUSE
Delta(3,5)-Delta(2,4)-dienoyl-CoA i...
Ech1
177Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030343 mRNA Translation: AAB84224.1
BC068112 mRNA Translation: AAH68112.1
BC087924 mRNA Translation: AAH87924.1
CCDSiCCDS21057.1
RefSeqiNP_058052.1, NM_016772.1
UniGeneiMm.291776

Genome annotation databases

EnsembliENSMUST00000066264; ENSMUSP00000066092; ENSMUSG00000053898
GeneIDi51798
KEGGimmu:51798
UCSCiuc009gab.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030343 mRNA Translation: AAB84224.1
BC068112 mRNA Translation: AAH68112.1
BC087924 mRNA Translation: AAH87924.1
CCDSiCCDS21057.1
RefSeqiNP_058052.1, NM_016772.1
UniGeneiMm.291776

3D structure databases

ProteinModelPortaliO35459
SMRiO35459
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206181, 1 interactor
IntActiO35459, 4 interactors
MINTiO35459
STRINGi10090.ENSMUSP00000066092

PTM databases

iPTMnetiO35459
PhosphoSitePlusiO35459
SwissPalmiO35459

2D gel databases

REPRODUCTION-2DPAGEiO35459

Proteomic databases

EPDiO35459
MaxQBiO35459
PaxDbiO35459
PeptideAtlasiO35459
PRIDEiO35459

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066264; ENSMUSP00000066092; ENSMUSG00000053898
GeneIDi51798
KEGGimmu:51798
UCSCiuc009gab.1 mouse

Organism-specific databases

CTDi1891
MGIiMGI:1858208 Ech1

Phylogenomic databases

eggNOGiKOG1681 Eukaryota
ENOG410XTHX LUCA
GeneTreeiENSGT00890000139344
HOGENOMiHOG000027939
HOVERGENiHBG005556
InParanoidiO35459
KOiK12663
OMAiHKACIGA
OrthoDBiEOG091G0H26
PhylomeDBiO35459
TreeFamiTF314317

Enzyme and pathway databases

UniPathwayi
UPA00659

ReactomeiR-MMU-9033241 Peroxisomal protein import

Miscellaneous databases

PROiPR:O35459
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053898 Expressed in 293 organ(s), highest expression level in brown adipose tissue
CleanExiMM_ECH1
ExpressionAtlasiO35459 baseline and differential
GenevisibleiO35459 MM

Family and domain databases

Gene3Di1.10.12.10, 1 hit
InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 Enoyl-CoA_hydra_C
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiECH1_MOUSE
AccessioniPrimary (citable) accession number: O35459
Secondary accession number(s): Q5M8P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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