Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C chemokine receptor-like 2

Gene

Ccrl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity).By similarity3 Publications

Miscellaneous

It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report (PubMed:14999816). These results are now controversial and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:18794339).2 Publications

GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: MGI
  • CCR chemokine receptor binding Source: MGI
  • chemokine binding Source: GO_Central
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor-like 2
Alternative name(s):
Chemokine receptor CCR11
G-protein coupled beta chemokine receptor
Lipopolysaccharide-inducible C-C chemokine receptor
Short name:
L-CCR
Gene namesi
Name:Ccrl2
Synonyms:Ccr11, Lccr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920904 Ccrl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 73CytoplasmicSequence analysis10
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 109ExtracellularSequence analysisAdd BLAST15
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 141CytoplasmicSequence analysisAdd BLAST11
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 202ExtracellularSequence analysisAdd BLAST40
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 243CytoplasmicSequence analysisAdd BLAST20
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 285ExtracellularSequence analysisAdd BLAST21
Transmembranei286 – 307Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini308 – 360CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Deficient-mice have normal numbers of mast cells in all tissues analyzed. Wild-type and deficient mice develop marked local inflammation when sensitized with a high dose of DNP-specific IgE, however deficient mice have significantly reduced IgE-dependent passive cutaneous anaphylaxis (PCA) reactions when lower sensitizing dose is used. Deficient-mice show normal recruitment of circulating DC into the lung, but a defective trafficking of antigen-loaded lung DC to mediastinal lymph nodes. This defect was associated to a reduction in lymph node cellularity and reduced priming of T-helper cell 2 response.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002368001 – 360C-C chemokine receptor-like 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 185PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35457
PRIDEiO35457

PTM databases

PhosphoSitePlusiO35457

Expressioni

Tissue specificityi

Expressed in macrophages, astrocytes, in glial cells. Constitutively expressed by mast cells. Detected in bronchial epithelium in OVA-induced airway inflammation. Up-regulated during dendritic cell (DC) maturation.5 Publications

Inductioni

By bacterial lipopolysaccharide in astrocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000043953 Expressed in 103 organ(s), highest expression level in spinal cord
CleanExiMM_CCRL2
ExpressionAtlasiO35457 baseline and differential
GenevisibleiO35457 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107519

Structurei

3D structure databases

ProteinModelPortaliO35457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKE4 Eukaryota
ENOG411157E LUCA
GeneTreeiENSGT00930000150855
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO35457
KOiK08373
OMAiLLMWAPY
OrthoDBiEOG091G0FG5
PhylomeDBiO35457
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35457-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNYTVAPDD EYDVLILDDY LDNSGPDQVP APEFLSPQQV LQFCCAVFAV
60 70 80 90 100
GLLDNVLAVF ILVKYKGLKN LGNIYFLNLA LSNLCFLLPL PFWAHTAAHG
110 120 130 140 150
ESPGNGTCKV LVGLHSSGLY SEVFSNILLL VQGYRVFSQG RLASIFTTVS
160 170 180 190 200
CGIVACILAW AMATALSLPE SVFYEPRMER QKHKCAFGKP HFLPIEAPLW
210 220 230 240 250
KYVLTSKMII LVLAFPLLVF IICCRQLRRR QSFRERQYDL HKPALVITGV
260 270 280 290 300
FLLMWAPYNT VLFLSAFQEH LSLQDEKSSY HLDASVQVTQ LVATTHCCVN
310 320 330 340 350
PLLYLLLDRK AFMRYLRSLF PRCNDIPYQS SGGYQQAPPR EGHGRPIELY
360
SNLHQRQDII
Length:360
Mass (Da):40,745
Last modified:May 30, 2006 - v2
Checksum:iE0DBF990A8595E3B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFB5A0A0G2JFB5_MOUSE
C-C chemokine receptor-like 2
Ccrl2
133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37P → S in BAE26775 (PubMed:16141072).Curated1
Sequence conflicti39Q → R in CAC79612 (PubMed:12555200).Curated1
Sequence conflicti157I → V in AAB86479 (Ref. 3) Curated1
Sequence conflicti215F → L in CAC79612 (PubMed:12555200).Curated1
Sequence conflicti292V → A in CAC79612 (PubMed:12555200).Curated1
Sequence conflicti334Y → S in AAB86479 (Ref. 3) Curated1
Sequence conflicti341E → K in AAB86479 (Ref. 3) Curated1
Sequence conflicti359I → K in CAJ18456 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009384 mRNA Translation: BAA25879.1
AJ318863 mRNA Translation: CAC79612.1
AF316576 mRNA Translation: AAG30950.1
AF030185 mRNA Translation: AAB86479.1
AK007808 mRNA Translation: BAB25273.1
AK145946 mRNA Translation: BAE26775.1
AK151856 mRNA Translation: BAE30745.1
CT010248 mRNA Translation: CAJ18456.1
BC038631 mRNA Translation: AAH38631.1
CCDSiCCDS23582.1
RefSeqiNP_001289305.1, NM_001302376.1
NP_001289306.1, NM_001302377.1
NP_059494.2, NM_017466.5
UniGeneiMm.7336

Genome annotation databases

EnsembliENSMUST00000111888; ENSMUSP00000107519; ENSMUSG00000043953
ENSMUST00000199839; ENSMUSP00000143116; ENSMUSG00000043953
GeneIDi54199
KEGGimmu:54199
UCSCiuc009rvk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009384 mRNA Translation: BAA25879.1
AJ318863 mRNA Translation: CAC79612.1
AF316576 mRNA Translation: AAG30950.1
AF030185 mRNA Translation: AAB86479.1
AK007808 mRNA Translation: BAB25273.1
AK145946 mRNA Translation: BAE26775.1
AK151856 mRNA Translation: BAE30745.1
CT010248 mRNA Translation: CAJ18456.1
BC038631 mRNA Translation: AAH38631.1
CCDSiCCDS23582.1
RefSeqiNP_001289305.1, NM_001302376.1
NP_001289306.1, NM_001302377.1
NP_059494.2, NM_017466.5
UniGeneiMm.7336

3D structure databases

ProteinModelPortaliO35457
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107519

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO35457

Proteomic databases

PaxDbiO35457
PRIDEiO35457

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111888; ENSMUSP00000107519; ENSMUSG00000043953
ENSMUST00000199839; ENSMUSP00000143116; ENSMUSG00000043953
GeneIDi54199
KEGGimmu:54199
UCSCiuc009rvk.2 mouse

Organism-specific databases

CTDi9034
MGIiMGI:1920904 Ccrl2

Phylogenomic databases

eggNOGiENOG410IKE4 Eukaryota
ENOG411157E LUCA
GeneTreeiENSGT00930000150855
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO35457
KOiK08373
OMAiLLMWAPY
OrthoDBiEOG091G0FG5
PhylomeDBiO35457
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines

Miscellaneous databases

ChiTaRSiCcrl2 mouse
PROiPR:O35457
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043953 Expressed in 103 organ(s), highest expression level in spinal cord
CleanExiMM_CCRL2
ExpressionAtlasiO35457 baseline and differential
GenevisibleiO35457 MM

Family and domain databases

InterProiView protein in InterPro
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCRL2_MOUSE
AccessioniPrimary (citable) accession number: O35457
Secondary accession number(s): O70171
, Q3UKM6, Q4FK04, Q91YD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again