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Protein

FK506-binding protein-like

Gene

Fkbpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.By similarity

GO - Biological processi

  • regulation of angiogenesis Source: MGI
  • regulation of blood vessel branching Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:Fkbpl
Synonyms:Ng7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1932127 Fkbpl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898791 – 347FK506-binding protein-likeAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35450
PaxDbiO35450
PeptideAtlasiO35450
PRIDEiO35450

PTM databases

iPTMnetiO35450
PhosphoSitePlusiO35450

Expressioni

Gene expression databases

BgeeiENSMUSG00000033739 Expressed in 192 organ(s), highest expression level in testis
CleanExiMM_FKBPL
ExpressionAtlasiO35450 baseline and differential
GenevisibleiO35450 MM

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.By similarity

Protein-protein interaction databases

IntActiO35450, 1 interactor
STRINGi10090.ENSMUSP00000037273

Structurei

3D structure databases

ProteinModelPortaliO35450
SMRiO35450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati208 – 241TPR 1Add BLAST34
Repeati250 – 283TPR 2Add BLAST34
Repeati284 – 317TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00920000149187
HOGENOMiHOG000272638
HOVERGENiHBG099465
InParanoidiO35450
KOiK20097
OMAiLESMCQG
OrthoDBiEOG091G0G4G
PhylomeDBiO35450
TreeFamiTF105297

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSPISPMN EKNTAQPQQR EENAQQILNT AIPFRQRSPG LLPEALKVGV
60 70 80 90 100
RPDPANQIVE TQEIEHPVAG FEGDSDQFQV STNEMAEHLQ ASDLWYCPDG
110 120 130 140 150
SFVKKIIVPG HGLDKPKLGS KCQVLALGFP FGSGMPEGWT ELTIGIGQWR
160 170 180 190 200
EKMWGELMEK CLESMRQGEE AKIHLPGSSA PLAKLRLDSF TNGRDSWEME
210 220 230 240 250
AMEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT LPPPGPPERT
260 270 280 290 300
TLYANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVARAALGDL
310 320 330 340
EKATADFKKV LAVDPKNRAA KEELGKVVIQ GRKQDAGLAR GLRKMFS
Length:347
Mass (Da):38,302
Last modified:January 1, 1998 - v1
Checksum:i33C1B20B4CC8FF83
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UY63G3UY63_MOUSE
FK506-binding protein-like
Fkbpl
21Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187L → M in BAE26836 (PubMed:16141072).Curated1
Sequence conflicti252L → I in BAE26836 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146018 mRNA Translation: BAE26836.1
AF030001 Genomic DNA Translation: AAB82013.1
BC046338 mRNA Translation: AAH46338.1
CCDSiCCDS28654.1
PIRiT09068
RefSeqiNP_063926.1, NM_019873.2
XP_006524724.1, XM_006524661.3
XP_006524725.1, XM_006524662.3
UniGeneiMm.10025

Genome annotation databases

EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739
GeneIDi56299
KEGGimmu:56299
UCSCiuc008cdg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146018 mRNA Translation: BAE26836.1
AF030001 Genomic DNA Translation: AAB82013.1
BC046338 mRNA Translation: AAH46338.1
CCDSiCCDS28654.1
PIRiT09068
RefSeqiNP_063926.1, NM_019873.2
XP_006524724.1, XM_006524661.3
XP_006524725.1, XM_006524662.3
UniGeneiMm.10025

3D structure databases

ProteinModelPortaliO35450
SMRiO35450
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35450, 1 interactor
STRINGi10090.ENSMUSP00000037273

PTM databases

iPTMnetiO35450
PhosphoSitePlusiO35450

Proteomic databases

MaxQBiO35450
PaxDbiO35450
PeptideAtlasiO35450
PRIDEiO35450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739
GeneIDi56299
KEGGimmu:56299
UCSCiuc008cdg.1 mouse

Organism-specific databases

CTDi63943
MGIiMGI:1932127 Fkbpl

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00920000149187
HOGENOMiHOG000272638
HOVERGENiHBG099465
InParanoidiO35450
KOiK20097
OMAiLESMCQG
OrthoDBiEOG091G0G4G
PhylomeDBiO35450
TreeFamiTF105297

Enzyme and pathway databases

ReactomeiR-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint

Miscellaneous databases

PROiPR:O35450
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033739 Expressed in 192 organ(s), highest expression level in testis
CleanExiMM_FKBPL
ExpressionAtlasiO35450 baseline and differential
GenevisibleiO35450 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBPL_MOUSE
AccessioniPrimary (citable) accession number: O35450
Secondary accession number(s): Q3UKG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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