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Protein

Transcription factor 21

Gene

Tcf21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1.1 Publication

GO - Molecular functioni

  • androgen receptor binding Source: BHF-UCL
  • bHLH transcription factor binding Source: MGI
  • E-box binding Source: BHF-UCL
  • histone deacetylase binding Source: BHF-UCL
  • protein dimerization activity Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • branchiomeric skeletal muscle development Source: UniProtKB
  • bronchiole development Source: MGI
  • diaphragm development Source: UniProtKB
  • embryonic digestive tract morphogenesis Source: UniProtKB
  • epithelial cell differentiation Source: MGI
  • gland development Source: UniProtKB
  • glomerulus development Source: MGI
  • kidney development Source: MGI
  • lung alveolus development Source: MGI
  • lung morphogenesis Source: MGI
  • lung vasculature development Source: MGI
  • metanephric glomerular capillary formation Source: UniProtKB
  • metanephric mesenchymal cell differentiation Source: UniProtKB
  • morphogenesis of a branching structure Source: MGI
  • negative regulation of androgen receptor signaling pathway Source: BHF-UCL
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of histone deacetylation Source: BHF-UCL
  • reproductive structure development Source: MGI
  • respiratory system development Source: MGI
  • roof of mouth development Source: UniProtKB
  • Sertoli cell differentiation Source: UniProtKB
  • sex determination Source: MGI
  • sex differentiation Source: MGI
  • spleen development Source: UniProtKB
  • ureteric bud development Source: MGI
  • vasculature development Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 21
Short name:
TCF-21
Alternative name(s):
Capsulin
Epicardin
Podocyte-expressed 1
Short name:
Pod-1
Gene namesi
Name:Tcf21
Synonyms:Pod1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1202715 Tcf21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274651 – 179Transcription factor 21Add BLAST179

Proteomic databases

PaxDbiO35437
PRIDEiO35437

PTM databases

iPTMnetiO35437
PhosphoSitePlusiO35437

Expressioni

Tissue specificityi

Expressed at high levels in lung, kidney, gut, heart, ovary and podocytes (visceral glomerular epithelial cells). Also found in spleen, large intestine, uterus, bladder and testis.

Developmental stagei

Expressed during embryogenesis specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary, respiratory systems and in spiral septum of the heart and in epicardial precursor cells fated to form the coronary arteries. Expression pattern is sex- and stage-dependent during gonadogenesis. At 13.5 dpc expressed at higher levels in testis than ovary. In 3-month old adults expression drastically decreased in testis while it increased in ovary showing an opposite sex-dependent pattern in adults compared with fetuses. Expression in other organs was similar between the adults and the fetal stage.

Gene expression databases

BgeeiENSMUSG00000045680
CleanExiMM_TCF21
ExpressionAtlasiO35437 baseline and differential
GenevisibleiO35437 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').

GO - Molecular functioni

  • androgen receptor binding Source: BHF-UCL
  • bHLH transcription factor binding Source: MGI
  • histone deacetylase binding Source: BHF-UCL
  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi204005, 4 interactors
IntActiO35437, 1 interactor
MINTiO35437
STRINGi10090.ENSMUSP00000053178

Structurei

3D structure databases

ProteinModelPortaliO35437
SMRiO35437
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 131bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00710000106684
HOGENOMiHOG000261670
HOVERGENiHBG105298
InParanoidiO35437
OMAiSSNCEGA
OrthoDBiEOG091G0N6P
PhylomeDBiO35437
TreeFamiTF350742

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

O35437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGSLSDVE DLQEVEMLDC DSLKVDSNKE FGTSNESTEE GSNCENGSPQ
60 70 80 90 100
KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS
110 120 130 140 150
RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL
160 170
TWPFMVAGKP ENDLKEVVTA NRLCGTTAS
Length:179
Mass (Da):19,681
Last modified:January 1, 1998 - v1
Checksum:i7BA3892818DB355F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029753 mRNA Translation: AAB84256.1
AF047418 mRNA Translation: AAC62531.1
AF036945 mRNA Translation: AAC23537.1
AF035717 mRNA Translation: AAC62513.1
AB009453 mRNA Translation: BAA23883.1
AK011575 mRNA Translation: BAB27709.1
AK135423 mRNA Translation: BAE22527.1
AK157289 mRNA Translation: BAE34032.1
BC053525 mRNA Translation: AAH53525.1
CCDSiCCDS23732.1
RefSeqiNP_035675.1, NM_011545.1
UniGeneiMm.16497

Genome annotation databases

EnsembliENSMUST00000049930; ENSMUSP00000053178; ENSMUSG00000045680
GeneIDi21412
KEGGimmu:21412
UCSCiuc007eps.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTCF21_MOUSE
AccessioniPrimary (citable) accession number: O35437
Secondary accession number(s): Q3U023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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