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Protein

DNA-directed RNA polymerase III subunit RPC9

Gene

Crcp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiR-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC9
Short name:
RNA polymerase III subunit C9
Alternative name(s):
Calcitonin gene-related peptide-receptor component protein
Short name:
CGRP-RCP
Short name:
CGRP-receptor component protein
Short name:
CGRPRCP
Gene namesi
Name:Crcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1100818 Crcp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, DNA-directed RNA polymerase, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793361 – 148DNA-directed RNA polymerase III subunit RPC9Add BLAST148

Proteomic databases

EPDiO35427
MaxQBiO35427
PaxDbiO35427
PeptideAtlasiO35427
PRIDEiO35427

PTM databases

PhosphoSitePlusiO35427

Expressioni

Tissue specificityi

Ubiquitous. Most prevalent in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000025532 Expressed in 279 organ(s), highest expression level in testis
ExpressionAtlasiO35427 baseline and differential
GenevisibleiO35427 MM

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with POLR3H/RPC8. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026608

Structurei

3D structure databases

ProteinModelPortaliO35427
SMRiO35427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4168 Eukaryota
ENOG4111TUG LUCA
GeneTreeiENSGT00390000014189
HOGENOMiHOG000244081
HOVERGENiHBG023697
InParanoidiO35427
OMAiNKHSTGQ
OrthoDBiEOG091G0ZNH
PhylomeDBiO35427
TreeFamiTF323294

Family and domain databases

Gene3Di1.20.1250.40, 1 hit
InterProiView protein in InterPro
IPR010997 HRDC-like_sf
IPR006590 RNA_pol_Rpb4/RPC9_core
IPR005574 RPB4/RPC9
IPR038324 Rpb4/RPC9_sf
IPR038846 RPC9
PANTHERiPTHR15561 PTHR15561, 1 hit
PfamiView protein in Pfam
PF03874 RNA_pol_Rpb4, 1 hit
SMARTiView protein in SMART
SM00657 RPOL4c, 1 hit
SUPFAMiSSF47819 SSF47819, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35427-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKDANAAL LSNYEVFQLL TDLKEQRKES GKNKHSAGQQ NLNAITYETL
60 70 80 90 100
KYISKTPCRN QSPAIVQEFL TAMKSHKLTK AEKLQLLNHR PMTAVEIQLM
110 120 130 140
VEESEERLTE EQIEALLHTV TSILPAGPED EQSKSTSNDV AMEEEEPA
Length:148
Mass (Da):16,683
Last modified:January 1, 1998 - v1
Checksum:iE5E6B716A7F9AFEC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YU23A0A0J9YU23_MOUSE
Calcitonin gene-related peptide-rec...
Crcp mCG_12431
97Annotation score:
A0A0J9YVE5A0A0J9YVE5_MOUSE
Calcitonin gene-related peptide-rec...
Crcp mCG_12431
72Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028242 mRNA Translation: AAB84046.1
AF118271 mRNA Translation: AAD17244.1
BC012676 mRNA Translation: AAH12676.1
CCDSiCCDS19706.1
RefSeqiNP_031787.1, NM_007761.2
UniGeneiMm.18072
Mm.469947

Genome annotation databases

EnsembliENSMUST00000026608; ENSMUSP00000026608; ENSMUSG00000025532
GeneIDi12909
KEGGimmu:12909
UCSCiuc008zua.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028242 mRNA Translation: AAB84046.1
AF118271 mRNA Translation: AAD17244.1
BC012676 mRNA Translation: AAH12676.1
CCDSiCCDS19706.1
RefSeqiNP_031787.1, NM_007761.2
UniGeneiMm.18072
Mm.469947

3D structure databases

ProteinModelPortaliO35427
SMRiO35427
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026608

PTM databases

PhosphoSitePlusiO35427

Proteomic databases

EPDiO35427
MaxQBiO35427
PaxDbiO35427
PeptideAtlasiO35427
PRIDEiO35427

Protocols and materials databases

DNASUi12909
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026608; ENSMUSP00000026608; ENSMUSG00000025532
GeneIDi12909
KEGGimmu:12909
UCSCiuc008zua.1 mouse

Organism-specific databases

CTDi27297
MGIiMGI:1100818 Crcp

Phylogenomic databases

eggNOGiKOG4168 Eukaryota
ENOG4111TUG LUCA
GeneTreeiENSGT00390000014189
HOGENOMiHOG000244081
HOVERGENiHBG023697
InParanoidiO35427
OMAiNKHSTGQ
OrthoDBiEOG091G0ZNH
PhylomeDBiO35427
TreeFamiTF323294

Enzyme and pathway databases

ReactomeiR-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

PROiPR:O35427
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025532 Expressed in 279 organ(s), highest expression level in testis
ExpressionAtlasiO35427 baseline and differential
GenevisibleiO35427 MM

Family and domain databases

Gene3Di1.20.1250.40, 1 hit
InterProiView protein in InterPro
IPR010997 HRDC-like_sf
IPR006590 RNA_pol_Rpb4/RPC9_core
IPR005574 RPB4/RPC9
IPR038324 Rpb4/RPC9_sf
IPR038846 RPC9
PANTHERiPTHR15561 PTHR15561, 1 hit
PfamiView protein in Pfam
PF03874 RNA_pol_Rpb4, 1 hit
SMARTiView protein in SMART
SM00657 RPOL4c, 1 hit
SUPFAMiSSF47819 SSF47819, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPC9_MOUSE
AccessioniPrimary (citable) accession number: O35427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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