UniProtKB - O35426 (XBP1_MOUSE)
X-box-binding protein 1
Xbp1
Functioni
Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland (PubMed:10425189, PubMed:10652269, PubMed:16362047, PubMed:17612490).
Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (By similarity).
Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions (PubMed:23529610).
Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (PubMed:15486293).
By similarity6 PublicationsPlays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production. In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 production in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (By similarity).
Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16332684).
Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (PubMed:12902539).
Acts as a weak transcriptional factor. Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress. Binds to the ER stress response element (ERSE) upon ER stress. Binds to the consensus 5'-GATGACGTG[TG]N3[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences. Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner. Binds to the CDH5/VE-cadherin gene promoter region (By similarity).
By similarity2 PublicationsFunctions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11850408, PubMed:14559994).
Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation, and promotes as well membrane phospholipid biosynthesis necessary for ER expansion (PubMed:12612580, PubMed:17213183).
Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression. Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions. Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation. Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (By similarity).
Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation (PubMed:23623498, PubMed:25223794).
Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells (PubMed:12902539, PubMed:24753614).
Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance (PubMed:20348926).
Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels (PubMed:21317886).
Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (PubMed:18556558).
Binds to the 5'-CCACG-3' motif in the PPARG promoter (PubMed:25223794).
Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner. Binds to the BECN1 gene promoter region. Binds to the CDH5/VE-cadherin gene promoter region. Binds to the ER stress response element (ERSE) upon ER stress (By similarity).
By similarity11 PublicationsGO - Molecular functioni
- chromatin DNA binding Source: UniProtKB
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: ParkinsonsUK-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- histone deacetylase binding Source: UniProtKB
- identical protein binding Source: MGI
- phosphatidylinositol 3-kinase regulatory subunit binding Source: UniProtKB
- protease binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein kinase binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific DNA binding Source: ParkinsonsUK-UCL
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: UniProtKB
- ubiquitin-like protein ligase binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: MGI
GO - Biological processi
- adipose tissue development Source: UniProtKB
- angiogenesis Source: UniProtKB
- autophagy Source: UniProtKB-KW
- cellular response to amino acid stimulus Source: UniProtKB
- cellular response to fluid shear stress Source: UniProtKB
- cellular response to fructose stimulus Source: UniProtKB
- cellular response to glucose starvation Source: UniProtKB
- cellular response to glucose stimulus Source: UniProtKB
- cellular response to insulin stimulus Source: UniProtKB
- cellular response to interleukin-4 Source: UniProtKB
- cellular response to laminar fluid shear stress Source: UniProtKB
- cellular response to leukemia inhibitory factor Source: MGI
- cellular response to lipopolysaccharide Source: UniProtKB
- cellular response to nutrient Source: UniProtKB
- cellular response to oxidative stress Source: UniProtKB
- cellular response to peptide hormone stimulus Source: UniProtKB
- cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
- cellular triglyceride homeostasis Source: UniProtKB
- cholesterol homeostasis Source: UniProtKB
- endoplasmic reticulum unfolded protein response Source: UniProtKB
- endothelial cell proliferation Source: UniProtKB
- epithelial cell maturation Source: MGI
- epithelial cell maturation involved in salivary gland development Source: MGI
- exocrine pancreas development Source: MGI
- fatty acid homeostasis Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
- lipid metabolic process Source: UniProtKB-KW
- liver development Source: UniProtKB
- muscle organ development Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
- negative regulation of endoplasmic reticulum unfolded protein response Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: MGI
- negative regulation of myotube differentiation Source: UniProtKB
- negative regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
- neuron development Source: UniProtKB
- phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of angiogenesis Source: MGI
- positive regulation of autophagy Source: UniProtKB
- positive regulation of B cell differentiation Source: UniProtKB
- positive regulation of cell migration Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of endoplasmic reticulum unfolded protein response Source: MGI
- positive regulation of endothelial cell apoptotic process Source: UniProtKB
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of hepatocyte proliferation Source: UniProtKB
- positive regulation of histone methylation Source: UniProtKB
- positive regulation of immunoglobulin production Source: UniProtKB
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of lactation Source: UniProtKB
- positive regulation of MHC class II biosynthetic process Source: UniProtKB
- positive regulation of plasma cell differentiation Source: UniProtKB
- positive regulation of protein acetylation Source: UniProtKB
- positive regulation of protein import into nucleus Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of T cell differentiation Source: UniProtKB
- positive regulation of TOR signaling Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response Source: UniProtKB
- positive regulation of vascular wound healing Source: MGI
- protein destabilization Source: UniProtKB
- protein transport Source: UniProtKB-KW
- regulation of autophagy Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- regulation of protein stability Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- response to electrical stimulus Source: MGI
- response to endoplasmic reticulum stress Source: UniProtKB
- response to insulin-like growth factor stimulus Source: UniProtKB
- response to xenobiotic stimulus Source: MGI
- serotonin secretion, neurotransmission Source: MGI
- sterol homeostasis Source: UniProtKB
- transcription by RNA polymerase II Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: UniProtKB
- vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Angiogenesis, Apoptosis, Autophagy, Differentiation, Lipid biosynthesis, Lipid metabolism, Myogenesis, Protein transport, Stress response, Transcription, Transcription regulation, Transport, Unfolded protein response |
Names & Taxonomyi
Protein namesi | Recommended name: X-box-binding protein 1By similarityImportedShort name: XBP-1By similarity Alternative name(s): Tax-responsive element-binding protein 51 Publication Short name: TREB-5Curated Cleaved into the following 2 chains: X-box-binding protein 1, cytoplasmic formBy similarity X-box-binding protein 1, luminal formBy similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98970, Xbp1 |
VEuPathDBi | HostDB:ENSMUSG00000020484 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Note: Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity).By similarity
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
- Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Note: Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (By similarity). Shows no preferential localization to either the nucleus or the cytoplasm (PubMed:16332684).By similarity1 Publication
Nucleus
- Nucleus 4 Publications
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Localizes predominantly in the nucleus (PubMed:16332684). Colocalizes in the nucleus with SIRT1 (PubMed:20955178). Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (PubMed:20348926).4 Publications
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- integral component of endoplasmic reticulum membrane Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- presynapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 180 | CytoplasmicBy similarityAdd BLAST | 180 | |
Transmembranei | 181 – 198 | Helical; Signal-anchor for type II membrane proteinSequence analysisBy similarityAdd BLAST | 18 | |
Topological domaini | 199 – 267 | LumenalBy similarityAdd BLAST | 69 |
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Membrane, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 177 – 178 | PP → LH: Reduces degradation (isoform 1); when associated with 238-L-H-239. 1 Publication | 2 | |
Mutagenesisi | 231 | K → R: Enhances stability and accumulates in the cytoplasm; when associated with R-252 (isoform 1). 2 Publications | 1 | |
Mutagenesisi | 238 – 239 | PP → LH: Reduces degradation (isoform 1); when associated with 177-L-H-178. 1 Publication | 2 | |
Mutagenesisi | 252 | K → R: Enhances stability and accumulates in the cytoplasm; when associated with R-231 (isoform 1). 2 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076544 | 1 – 267 | X-box-binding protein 1Add BLAST | 267 | |
ChainiPRO_0000431893 | 1 – 188 | X-box-binding protein 1, cytoplasmic formBy similarityAdd BLAST | 188 | |
ChainiPRO_0000431894 | 191 – 267 | X-box-binding protein 1, luminal formBy similarityAdd BLAST | 77 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 61 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 185 – 186 | Cleavage; by HM13/SPPBy similarity | 2 |
Keywords - PTMi
Acetylation, Cleavage on pair of basic residues, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | O35426 |
PRIDEi | O35426 |
ProteomicsDBi | 297567 [O35426-1] 297568 [O35426-2] |
PTM databases
iPTMneti | O35426 |
PhosphoSitePlusi | O35426 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000020484, Expressed in lacrimal gland and 330 other tissues |
ExpressionAtlasi | O35426, baseline and differential |
Genevisiblei | O35426, MM |
Interactioni
Subunit structurei
Isoform 1 interacts with HM13.
Isoform 1 interacts with RNF139; the interaction induces ubiquitination and degradation of isoform 1. Isoform 1 interacts (via luminal domain) with DERL1; the interaction obviates the need for ectodomain shedding prior HM13/SPP-mediated XBP1 isoform 1 cleavage.
Isoform 1 interacts with isoform 2; the interaction sequesters isoform 2 from the nucleus and enhances isoform 2 degradation in the cytoplasm.
Isoform 1 interacts with HDAC3 and AKT1; the interactions occur in endothelial cell (EC) under disturbed flow.
Isoform 1 interacts with the oncoprotein FOS.
Isoform 2 interacts with ATF6; the interaction occurs in a ER stress-dependent manner and is required for DNA binding to the unfolded protein response element (UPRE).
Isoform 2 interacts with PIK3R1; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus and the unfolded protein response (UPR) XBP1-dependent target genes activation in a ER stress- and/or insulin-dependent but PI3K-independent manner (By similarity).
Isoform 2 interacts with SIRT1 (PubMed:20955178).
Isoform 2 interacts with PIK3R1 and PIK3R2; the interactions are direct and induce translocation of XBP1 isoform 2 into the nucleus and the unfolded protein response (UPR) XBP1-dependent target genes activation in a ER stress- and/or insulin-dependent but PI3K-independent manner (PubMed:20348926).
Isoform 2 interacts with FOXO1; the interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway in hepatocytes (PubMed:21317886).
By similarity3 PublicationsGO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
- identical protein binding Source: MGI
- phosphatidylinositol 3-kinase regulatory subunit binding Source: UniProtKB
- protease binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein kinase binding Source: MGI
- ubiquitin-like protein ligase binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204589, 11 interactors |
IntActi | O35426, 1 interactor |
STRINGi | 10090.ENSMUSP00000054852 |
Miscellaneous databases
RNActi | O35426, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 63 – 126 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 56 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 65 – 87 | Basic motifPROSITE-ProRule annotationAdd BLAST | 23 | |
Regioni | 69 – 85 | Nuclear localization signal (NLS); in isoforms 1 and isoform 2By similarityAdd BLAST | 17 | |
Regioni | 91 – 126 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 36 | |
Regioni | 230 – 256 | Necessary for the translational pausing of its own mRNABy similarityAdd BLAST | 27 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4005, Eukaryota |
GeneTreei | ENSGT00390000017751 |
HOGENOMi | CLU_093516_0_0_1 |
InParanoidi | O35426 |
OrthoDBi | 1269901at2759 |
PhylomeDBi | O35426 |
TreeFami | TF319837 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVVVAAAPSA ATAAPKVLLL SGQPASGGRA LPLMVPGPRA AGSEASGTPQ
60 70 80 90 100
ARKRQRLTHL SPEEKALRRK LKNRVAAQTA RDRKKARMSE LEQQVVDLEE
110 120 130 140 150
ENHKLQLENQ LLREKTHGLV VENQELRTRL GMDTLDPDEV PEVEAKGSGV
160 170 180 190 200
RLVAGSAESA ALRLCAPLQQ VQAQLSPPQN IFPWTLTLLP LQILSLISFW
210 220 230 240 250
AFWTSWTLSC FSNVLPQSLL VWRNSQRSTQ KDLVPYQPPF LCQWGPHQPS
260
WKPLMNSFVL TMYTPSL
The sequence of this isoform differs from the canonical sequence as follows:
162-267: LRLCAPLQQV...FVLTMYTPSL → GAGPVVTSPE...NELFPQLISV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F8MPD3 | A0A5F8MPD3_MOUSE | X-box-binding protein 1 | Xbp1 | 371 | Annotation score: | ||
G3UYH6 | G3UYH6_MOUSE | X-box-binding protein 1 | Xbp1 | 127 | Annotation score: | ||
H3BLF6 | H3BLF6_MOUSE | X-box-binding protein 1 | Xbp1 | 214 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | Missing in BAB13793 (PubMed:10907849).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012937 | 162 – 267 | LRLCA…YTPSL → GAGPVVTSPEHLPMDSDTVA SSDSESDILLGILDKLDPVM FFKCPSPESASLEELPEVYP EGPSSLPASLSLSVGTSSAK LEAINELIRFDHVYTKPLVL EIPSETESQTNVVVKIEEAP LSSSEEDHPEFIVSVKKEPL EDDFIPELGISNLLSSSHCL RPPSCLLDAHSDCGYEGSPS PFSDMSSPLGTDHSWEDTFA NELFPQLISV in isoform 2. 1 PublicationAdd BLAST | 106 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB036745 Genomic DNA Translation: BAB13793.1 AF443192 mRNA Translation: AAL60202.1 AF027963 mRNA Translation: AAB81862.2 AL662876 Genomic DNA No translation available. BC008153 mRNA Translation: AAH08153.1 BC029197 mRNA Translation: AAH29197.1 |
CCDSi | CCDS24400.1 [O35426-1] |
PIRi | JC7300 |
RefSeqi | NP_001258659.1, NM_001271730.1 [O35426-2] NP_038870.2, NM_013842.3 [O35426-1] |
Genome annotation databases
Ensembli | ENSMUST00000063084; ENSMUSP00000054852; ENSMUSG00000020484 [O35426-1] |
GeneIDi | 22433 |
KEGGi | mmu:22433 |
UCSCi | uc007hwm.2, mouse [O35426-2] uc007hwn.2, mouse [O35426-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB036745 Genomic DNA Translation: BAB13793.1 AF443192 mRNA Translation: AAL60202.1 AF027963 mRNA Translation: AAB81862.2 AL662876 Genomic DNA No translation available. BC008153 mRNA Translation: AAH08153.1 BC029197 mRNA Translation: AAH29197.1 |
CCDSi | CCDS24400.1 [O35426-1] |
PIRi | JC7300 |
RefSeqi | NP_001258659.1, NM_001271730.1 [O35426-2] NP_038870.2, NM_013842.3 [O35426-1] |
3D structure databases
SMRi | O35426 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204589, 11 interactors |
IntActi | O35426, 1 interactor |
STRINGi | 10090.ENSMUSP00000054852 |
PTM databases
iPTMneti | O35426 |
PhosphoSitePlusi | O35426 |
Proteomic databases
PaxDbi | O35426 |
PRIDEi | O35426 |
ProteomicsDBi | 297567 [O35426-1] 297568 [O35426-2] |
Protocols and materials databases
Antibodypediai | 10221, 709 antibodies from 43 providers |
DNASUi | 22433 |
Genome annotation databases
Ensembli | ENSMUST00000063084; ENSMUSP00000054852; ENSMUSG00000020484 [O35426-1] |
GeneIDi | 22433 |
KEGGi | mmu:22433 |
UCSCi | uc007hwm.2, mouse [O35426-2] uc007hwn.2, mouse [O35426-1] |
Organism-specific databases
CTDi | 7494 |
MGIi | MGI:98970, Xbp1 |
VEuPathDBi | HostDB:ENSMUSG00000020484 |
Phylogenomic databases
eggNOGi | KOG4005, Eukaryota |
GeneTreei | ENSGT00390000017751 |
HOGENOMi | CLU_093516_0_0_1 |
InParanoidi | O35426 |
OrthoDBi | 1269901at2759 |
PhylomeDBi | O35426 |
TreeFami | TF319837 |
Miscellaneous databases
BioGRID-ORCSi | 22433, 7 hits in 69 CRISPR screens |
ChiTaRSi | Xbp1, mouse |
PROi | PR:O35426 |
RNActi | O35426, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020484, Expressed in lacrimal gland and 330 other tissues |
ExpressionAtlasi | O35426, baseline and differential |
Genevisiblei | O35426, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | XBP1_MOUSE | |
Accessioni | O35426Primary (citable) accession number: O35426 Secondary accession number(s): Q8VHM0, Q922G5, Q9ESS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families