UniProtKB - O35424 (O35424_MOUSE)
Protein
Submitted name:
Histocompatibility 2, O region beta locus
Gene
H2-Ob
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- MHC class II protein complex binding Source: MGI
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
- negative regulation of antigen processing and presentation of peptide antigen via MHC class II Source: MGI
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation |
Names & Taxonomyi
Protein namesi | Submitted name: Histocompatibility 2, O region beta locusImportedSubmitted name: IAbeta2 subunitImported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95925, H2-Ob |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Lysosome
- lysosome Source: MGI
Plasma Membrane
- MHC class II protein complex Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 225 – 247 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Membrane, MHC IIARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015096771 | 22 – 271 | Sequence analysisAdd BLAST | 250 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000041538, Expressed in lymph node and 102 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 123 – 213 | Ig-likeInterPro annotationAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the MHC class II family.ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | ENOG502RWX2, Eukaryota |
GeneTreei | ENSGT00940000162353 |
HOGENOMi | CLU_047501_13_1_1 |
OMAi | PDAERWN |
OrthoDBi | 1249505at2759 |
TreeFami | TF336626 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O35424-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAGRAPWVV ALLVNLMRLD SFMIEGRDSP ENFVIQAKAD CYFTNGTEKV
60 70 80 90 100
HLLVRFIFNL EEYLHFDSDL GMFVALTELG EPDADQWNKR LDLLETSRAA
110 120 130 140 150
VNMVCRQKYK LGAPFTVERN VPPEVTVYPE RTPLLQQHNL LLCSVTGFYP
160 170 180 190 200
GDISVKWFRN GQEERSGVMS TGLVRNGDWT FQTTVMLEMI PELGDIYSCL
210 220 230 240 250
VEHPGLLRPV SVAWMAQSEY SWKKILSGAA VFLLGLIVFL VGVVIHLKAQ
260 270
KASVETQPGN EASRESLHSQ P
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q479 | E9Q479_MOUSE | Histocompatibility 2, O region beta... | H2-Ob | 245 | Annotation score: | ||
A0A494BB12 | A0A494BB12_MOUSE | Histocompatibility 2, O region beta... | H2-Ob | 303 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR974422 Genomic DNA No translation available. AF027865 Genomic DNA Translation: AAB81530.1 |
PIRi | A23884 |
RefSeqi | NP_034519.2, NM_010389.3 |
Genome annotation databases
Ensembli | ENSMUST00000095342; ENSMUSP00000092985; ENSMUSG00000041538 |
GeneIDi | 15002 |
KEGGi | mmu:15002 |
UCSCi | uc008cca.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR974422 Genomic DNA No translation available. AF027865 Genomic DNA Translation: AAB81530.1 |
PIRi | A23884 |
RefSeqi | NP_034519.2, NM_010389.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000092985 |
Protocols and materials databases
Antibodypediai | 34891, 186 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000095342; ENSMUSP00000092985; ENSMUSG00000041538 |
GeneIDi | 15002 |
KEGGi | mmu:15002 |
UCSCi | uc008cca.1, mouse |
Organism-specific databases
CTDi | 15002 |
MGIi | MGI:95925, H2-Ob |
Phylogenomic databases
eggNOGi | ENOG502RWX2, Eukaryota |
GeneTreei | ENSGT00940000162353 |
HOGENOMi | CLU_047501_13_1_1 |
OMAi | PDAERWN |
OrthoDBi | 1249505at2759 |
TreeFami | TF336626 |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation |
Miscellaneous databases
BioGRID-ORCSi | 15002, 0 hits in 19 CRISPR screens |
ChiTaRSi | H2-Ob, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041538, Expressed in lymph node and 102 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O35424_MOUSE | |
Accessioni | O35424Primary (citable) accession number: O35424 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 1, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |