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Entry version 135 (02 Jun 2021)
Sequence version 2 (22 Jul 2008)
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Protein

Sorbin and SH3 domain-containing protein 2

Gene

Sorbs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity).

May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity).

Isoform 2 increases water and sodium absorption in the intestine and gall-bladder.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorbin and SH3 domain-containing protein 2
Alternative name(s):
Arg-binding protein 2
Short name:
ArgBP2
Arg/Abl-interacting protein 2
Neural ArgBP2
Short name:
nArgBP2
Sorbin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sorbs2
Synonyms:Argbp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620061, Sorbs2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003444791 – 1196Sorbin and SH3 domain-containing protein 2Add BLAST1196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27PhosphoserineCombined sources1
Modified residuei28PhosphoserineBy similarity1
Modified residuei40PhosphoserineCombined sources1
Modified residuei130PhosphoserineBy similarity1
Modified residuei143PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei334PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei372PhosphothreonineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei387PhosphothreonineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei394PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei397PhosphoserineCombined sources1
Modified residuei399PhosphoserineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei589PhosphoserineCombined sources1
Modified residuei592PhosphoserineBy similarity1
Modified residuei645PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei844PhosphoserineCombined sources1
Modified residuei938PhosphoserineBy similarity1
Modified residuei1113PhosphoserineCombined sources1
Modified residuei1119PhosphoserineBy similarity1
Isoform 2 (identifier: O35413-2)
Modified residuei148Alanine amide1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by CBL.By similarity

Keywords - PTMi

Amidation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O35413

PRoteomics IDEntifications database

More...
PRIDEi
O35413

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O35413

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O35413

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain; found in synapses in cerebellum.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ABL1/c-Abl, ABL2/v-Abl/Arg, ACTN, CBL and PALLD (By similarity).

Interacts with ABL, CBL, DNM1, DNM2, FLOT1, AFDN, PTK2B/PYK2, SAPAP, SPTAN1, SYNJ1, SYNJ2, VCL/vinculin and WASF.

Interacts with PTPN12 and WASF1 via its SH3 domains; this interaction may mediate the partial PTPN12 and WASF1 translocation to focal adhesion sites.

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
250427, 8 interactors

Protein interaction database and analysis system

More...
IntActi
O35413, 3 interactors

Molecular INTeraction database

More...
MINTi
O35413

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000029182

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O35413

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini166 – 227SoHoPROSITE-ProRule annotationAdd BLAST62
Domaini959 – 1018SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini1034 – 1095SH3 2PROSITE-ProRule annotationAdd BLAST62
Domaini1137 – 1196SH3 3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 57DisorderedSequence analysisAdd BLAST33
Regioni75 – 95DisorderedSequence analysisAdd BLAST21
Regioni235 – 314DisorderedSequence analysisAdd BLAST80
Regioni329 – 407DisorderedSequence analysisAdd BLAST79
Regioni929 – 958DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 57Polar residuesSequence analysisAdd BLAST16
Compositional biasi77 – 95Polar residuesSequence analysisAdd BLAST19
Compositional biasi235 – 261Polar residuesSequence analysisAdd BLAST27
Compositional biasi278 – 308Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi366 – 403Polar residuesSequence analysisAdd BLAST38
Compositional biasi929 – 945Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first 2 SH3 domains are required for WASF1-binding. All 3 SH3 domains can bind independently to PTPN12.By similarity

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4225, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O35413

Database of Orthologous Groups

More...
OrthoDBi
228183at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O35413

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR14167:SF56, PTHR14167:SF56, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 3 hits
PS50831, SOHO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O35413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTDSGGCAR KRAAMSVTLT SVKRVQSSPN LLAAGRESHS PDSAWRSYNG
60 70 80 90 100
RNPETLNGDA TYSSLAAKGF RSVRPNLQDK KSPTQSHITI NGNSGGAVSP
110 120 130 140 150
VSYYQRPFSP SAYSLPASLN SSIIMPHGRS LDSAETYSQH AQSLDGTMGS
160 170 180 190 200
SIPLYRSSEE EKRVTVIKAP HYPGIGPVDE SGIPTAIRTT VDRPKDWYKT
210 220 230 240 250
MFKQIHMVHK PDEDTDMYNT PYTYNAGLYN SPYSAQSHPA AKTQTYRPLS
260 270 280 290 300
KSHSDNGTDA FKEATSPVPP PHVPPRPRDQ SSTEKHDWDP PDRKVDTRKF
310 320 330 340 350
RSEPRSIFEY EPGKSSILQH ERPVSVYQSS IDRSLERPSS SASMAGDFRK
360 370 380 390 400
RRKSEPAVGP PRGLGDHSSS RTSPGRADLP GSSSTFTTSF ISSSPSSPSR
410 420 430 440 450
AQGGDDSKMC PPLCSYSGLN GSPSSELECC GAYRRHLDVP QDSQRAITFK
460 470 480 490 500
NGWQMARQNA EIWSSTEEAV SPKIKSRSCD DLLNDDCGSF PDPKTKSESM
510 520 530 540 550
GSLLCDEGSK ESDPMTWTSP YIPEVCGNSR SRLKHRSAHN APGFLKMYKK
560 570 580 590 600
MHRINRKDLM NSEVICSVKS RILQYEKEQQ HRGLLHGWSQ SSTEEVPRDV
610 620 630 640 650
VPTRISEFEK LIQKSKSMPN LGDEMLSPVT LEPPQNGLCP KRRFSIESLL
660 670 680 690 700
EEETQVRHPS QGQRSCKSNT LVPIHIEVTS DEQPRTHMEF SDSDQDGVVS
710 720 730 740 750
DHSDNVHVER SSFCSESDFD HFSFTSSESF YGSSHHHHHH HHHHGHFISS
760 770 780 790 800
CKGRCPASYT RFTTMLKHER AKHENIDRPR RQDMDPGLSK LAFLVSPVPF
810 820 830 840 850
RRKKVLTPQK QTEQAKCKAS VVEALDSALK DICDQIKAEK RRGSLPDNSI
860 870 880 890 900
LHRLISELLP QIPKRNSSLN ALKRSPMHQP FHPLPQDGAI HCPLYQNDCG
910 920 930 940 950
RMPHSASFPD VDTTSSYHAQ DYGSVLSLQD HESPRSYSST LTDLGRSVSR
960 970 980 990 1000
ERRGTPEKEV KLPAKAVYDF KAQTSKELSF KKGDTVYILR KIDQNWYEGE
1010 1020 1030 1040 1050
HHGRVGIFPI SYVEKLTPPE KAQPARPPPP VQPGEIGEAI AKYNFNADTN
1060 1070 1080 1090 1100
VELSLRKGDR IILLKRVDQN WYEGKIPGTN RQGIFPVSYV EVVKRNTKGS
1110 1120 1130 1140 1150
EDYPDPPLPH SYSSDRIYSL SSNKPQRPVF SHENIQGGGE PFQALYNYTP
1160 1170 1180 1190
RNEDELELRE SDVVDVMEKC DDGWFVGTSR RTKFFGTFPG NYVKRL
Length:1,196
Mass (Da):134,057
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i122E5B7B0534B855
GO
Isoform 2 (identifier: O35413-2) [UniParc]FASTAAdd to basket
Also known as: Sorbin

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.
     182-185: GIPT → MISQ
     326-334: VYQSSIDRS → KPQAGRRKV
     335-1196: Missing.

Show »
Length:153
Mass (Da):17,709
Checksum:i0B0CE07EC7173125
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LPM3F1LPM3_RAT
Sorbin and SH3 domain-containing pr...
Sorbs2
1,196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti265T → P in AAB81527 (PubMed:10521485).Curated1
Sequence conflicti354S → V in AAK81861 (PubMed:11786189).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0348121 – 181Missing in isoform 2. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_034813182 – 185GIPT → MISQ in isoform 2. 1 Publication4
Alternative sequenceiVSP_034814326 – 334VYQSSIDRS → KPQAGRRKV in isoform 2. 1 Publication9
Alternative sequenceiVSP_034815335 – 1196Missing in isoform 2. 1 PublicationAdd BLAST862

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF026505 mRNA Translation: AAB81527.1
AF396458 mRNA Translation: AAK81861.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T14108

NCBI Reference Sequences

More...
RefSeqi
NP_446222.1, NM_053770.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:114901

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026505 mRNA Translation: AAB81527.1
AF396458 mRNA Translation: AAK81861.1
PIRiT14108
RefSeqiNP_446222.1, NM_053770.1

3D structure databases

SMRiO35413
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi250427, 8 interactors
IntActiO35413, 3 interactors
MINTiO35413
STRINGi10116.ENSRNOP00000029182

PTM databases

iPTMnetiO35413
PhosphoSitePlusiO35413

Proteomic databases

PaxDbiO35413
PRIDEiO35413

Genome annotation databases

GeneIDi114901
KEGGirno:114901

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8470
RGDi620061, Sorbs2

Phylogenomic databases

eggNOGiKOG4225, Eukaryota
InParanoidiO35413
OrthoDBi228183at2759
PhylomeDBiO35413

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O35413

Family and domain databases

InterProiView protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
IPR013087, Znf_C2H2_type
PANTHERiPTHR14167:SF56, PTHR14167:SF56, 1 hit
PfamiView protein in Pfam
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit
SUPFAMiSSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 3 hits
PS50831, SOHO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRBS2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35413
Secondary accession number(s): Q923T8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 2, 2021
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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