Transcription factor USF-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities."
    Bidder M., Shao J.S., Charlton-Kachigian N., Loewy A.P., Semenkovich C.F., Towler D.A.
    J. Biol. Chem. 277:44485-44496(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from direct assayⁱ
  • "Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities."
    Bidder M., Shao J.S., Charlton-Kachigian N., Loewy A.P., Semenkovich C.F., Towler D.A.
    J. Biol. Chem. 277:44485-44496(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Binding of upstream stimulatory factor 1 to the E-box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells."
    Ma Z., Jhun B., Jung S.Y., Oh C.K.
    J. Allergy Clin. Immunol. 121:1006-1012.e2(2008) [PubMed] [Europe PMC] [Abstract]
  • "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer."
    Gregor P.D., Sawadogo M., Roeder R.G.
    Genes Dev. 4:1730-1740(1990) [PubMed] [Europe PMC] [Abstract]
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: RGDInferred from direct assayⁱ
  • "Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells."
    Boonsaen T., Rojvirat P., Surinya K.H., Wallace J.C., Jitrapakdee S.
    Biochem. J. 405:359-367(2007) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: RGDInferred from sequence orthologyⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: RGDInferred from sequence orthologyⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from mutant phenotypeⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells."
    Boonsaen T., Rojvirat P., Surinya K.H., Wallace J.C., Jitrapakdee S.
    Biochem. J. 405:359-367(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to insulin stimulus Source: RGDInferred from sequence orthologyⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• glucose metabolic process Source: RGDInferred from direct assayⁱ
  • "Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities."
    Bidder M., Shao J.S., Charlton-Kachigian N., Loewy A.P., Semenkovich C.F., Towler D.A.
    J. Biol. Chem. 277:44485-44496(2002) [PubMed] [Europe PMC] [Abstract]
• late viral transcription Source: RGDInferred from sequence orthologyⁱ
  • "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer."
    Gregor P.D., Sawadogo M., Roeder R.G.
    Genes Dev. 4:1730-1740(1990) [PubMed] [Europe PMC] [Abstract]
• lipid homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver."
    Casado M., Vallet V.S., Kahn A., Vaulont S.
    J. Biol. Chem. 274:2009-2013(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site."
    Firlej V., Bocquet B., Desbiens X., de Launoit Y., Chotteau-Lelievre A.
    J. Biol. Chem. 280:887-898(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from direct assayⁱ
  • "UTP induces osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells."
    Renault M.A., Jalvy S., Potier M., Belloc I., Genot E., Dekker L.V., Desgranges C., Gadeau A.P.
    J. Biol. Chem. 280:2708-2713(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter by glucose Source: RGDInferred from sequence orthologyⁱ
  • "Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter."
    Lefrancois-Martinez A.M., Martinez A., Antoine B., Raymondjean M., Kahn A.
    J. Biol. Chem. 270:2640-2643(1995) [PubMed] [Europe PMC] [Abstract]
  • "Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver."
    Casado M., Vallet V.S., Kahn A., Vaulont S.
    J. Biol. Chem. 274:2009-2013(1999) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities."
    Bidder M., Shao J.S., Charlton-Kachigian N., Loewy A.P., Semenkovich C.F., Towler D.A.
    J. Biol. Chem. 277:44485-44496(2002) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from sequence orthologyⁱ
  • "USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia."
    Jiang B., Mendelson C.R.
    Mol. Cell. Biol. 23:6117-6128(2003) [PubMed] [Europe PMC] [Abstract]
• response to UV Source: RGDInferred from sequence orthologyⁱ
  • "UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)."
    Corre S., Primot A., Sviderskaya E., Bennett D.C., Vaulont S., Goding C.R., Galibert M.D.
    J. Biol. Chem. 279:51226-51233(2004) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer."
    Gregor P.D., Sawadogo M., Roeder R.G.
    Genes Dev. 4:1730-1740(1990) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: RGDInferred from sequence orthologyⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: RGDInferred from sequence orthologyⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGDInferred from mutant phenotypeⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV 
        60         70         80         90        100
FRTENGGQVM YRVIQVSEGQ LDGQTEGSGA ISGYPATQSM TQAVIQGAFT 
       110        120        130        140        150
SDDAVDAEGT AAETHYTYFP STAVGDGSGG TTSGSTTAVV TTQGSEALLG 
       160        170        180        190        200
QATPPSTGQF FVMMSPQEVL QGGSQRSIAP RTHPYSPKSE APRTTRDEKR 
       210        220        230        240        250
RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK GGILSKACDY 
       260        270        280        290        300
IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG 
       310
LEVVIKNDSN                                             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ