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UniProtKB - O35410 (O35410_RAT)
Protein
Submitted name:
Transcription factor USF-1
Gene
Usf1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- bHLH transcription factor binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- double-stranded DNA binding Source: RGD
- enzyme binding Source: RGD
- histone deacetylase binding Source: RGD
- identical protein binding Source: RGD
- protein-containing complex binding Source: RGD
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: RGD
- protein kinase binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- cellular response to insulin stimulus Source: RGD
- glucose metabolic process Source: RGD
- late viral transcription Source: RGD
- lipid homeostasis Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription from RNA polymerase II promoter by glucose Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: RGD
- response to hypoxia Source: RGD
- response to UV Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor USF-1ImportedSubmitted name: Upstream transcription factor 1ImportedSubmitted name: Upstream transcription factor 1, isoform CRA_aImported |
Gene namesi | Name:Usf1Imported ORF Names:rCG_20095Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Organism-specific databases
RGDi | 620974, Usf1 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleus Source: RGD
Other locations
- chromatin Source: RGD
- cytoplasmic ribonucleoprotein granule Source: Ensembl
- transcription regulator complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000004255, Expressed in thymus and 20 other tissues |
Interactioni
GO - Molecular functioni
- bHLH transcription factor binding Source: RGD
- enzyme binding Source: RGD
- histone deacetylase binding Source: RGD
- identical protein binding Source: RGD
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: RGD
- protein kinase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000005811 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 199 – 254 | BHLHInterPro annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 171 – 209 | DisorderedSequence analysisAdd BLAST | 39 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 251 – 295 | Sequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 190 – 209 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1318, Eukaryota |
GeneTreei | ENSGT00940000157083 |
HOGENOMi | CLU_070485_0_0_1 |
OMAi | KTIPECN |
OrthoDBi | 1345445at2759 |
TreeFami | TF323338 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
O35410-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV
60 70 80 90 100
FRTENGGQVM YRVIQVSEGQ LDGQTEGSGA ISGYPATQSM TQAVIQGAFT
110 120 130 140 150
SDDAVDAEGT AAETHYTYFP STAVGDGSGG TTSGSTTAVV TTQGSEALLG
160 170 180 190 200
QATPPSTGQF FVMMSPQEVL QGGSQRSIAP RTHPYSPKSE APRTTRDEKR
210 220 230 240 250
RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK GGILSKACDY
260 270 280 290 300
IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG
310
LEVVIKNDSN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF026476 mRNA Translation: AAB82712.1 BC088849 mRNA Translation: AAH88849.1 CH473985 Genomic DNA Translation: EDL94648.1 CH473985 Genomic DNA Translation: EDL94650.1 |
RefSeqi | NP_113965.1, NM_031777.2 XP_006250328.1, XM_006250266.2 |
Genome annotation databases
GeneIDi | 83586 |
KEGGi | rno:83586 |
UCSCi | RGD:620974, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF026476 mRNA Translation: AAB82712.1 BC088849 mRNA Translation: AAH88849.1 CH473985 Genomic DNA Translation: EDL94648.1 CH473985 Genomic DNA Translation: EDL94650.1 |
RefSeqi | NP_113965.1, NM_031777.2 XP_006250328.1, XM_006250266.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000005811 |
Genome annotation databases
GeneIDi | 83586 |
KEGGi | rno:83586 |
UCSCi | RGD:620974, rat |
Organism-specific databases
CTDi | 7391 |
RGDi | 620974, Usf1 |
Phylogenomic databases
eggNOGi | KOG1318, Eukaryota |
GeneTreei | ENSGT00940000157083 |
HOGENOMi | CLU_070485_0_0_1 |
OMAi | KTIPECN |
OrthoDBi | 1345445at2759 |
TreeFami | TF323338 |
Gene expression databases
Bgeei | ENSRNOG00000004255, Expressed in thymus and 20 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | O35410_RAT | |
Accessioni | O35410Primary (citable) accession number: O35410 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 1, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |