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Protein

Exocyst complex component 4

Gene

Exoc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
Gene namesi
Name:Exoc4
Synonyms:Sec8, Sec8l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1096376 Exoc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001189352 – 975Exocyst complex component 4Add BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei238PhosphothreonineBy similarity1
Modified residuei469PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35382
MaxQBiO35382
PaxDbiO35382
PeptideAtlasiO35382
PRIDEiO35382

PTM databases

iPTMnetiO35382
PhosphoSitePlusiO35382

Expressioni

Gene expression databases

BgeeiENSMUSG00000029763 Expressed in 290 organ(s), highest expression level in pituitary gland
CleanExiMM_EXOC4
ExpressionAtlasiO35382 baseline and differential
GenevisibleiO35382 MM

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP. Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Exoc7O352502EBI-772648,EBI-775332

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203152, 4 interactors
DIPiDIP-32368N
IntActiO35382, 11 interactors
MINTiO35382
STRINGi10090.ENSMUSP00000051965

Structurei

3D structure databases

ProteinModelPortaliO35382
SMRiO35382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 114Sequence analysisAdd BLAST83

Sequence similaritiesi

Belongs to the SEC8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3691 Eukaryota
ENOG410Z8N0 LUCA
GeneTreeiENSGT00390000001439
HOVERGENiHBG036151
InParanoidiO35382
KOiK06111
OMAiKEHRRNA
OrthoDBiEOG091G0QUY
TreeFamiTF313954

Family and domain databases

InterProiView protein in InterPro
IPR039682 Sec8/EXOC4
IPR007191 Sec8_exocyst
PANTHERiPTHR14146 PTHR14146, 1 hit
PfamiView protein in Pfam
PF04048 Sec8_exocyst, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35382-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA
60 70 80 90 100
YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC
110 120 130 140 150
KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY
160 170 180 190 200
LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIEELHRHL
210 220 230 240 250
YIKSTSRVVQ RNKEKGKMSS HGKDPSPGPL IDVSNIPTPR KFLDASQYSA
260 270 280 290 300
AGGSSVREMN LQDVKEDLEC DPEENSTLFM GILIQGLARL KKIPETVKAI
310 320 330 340 350
KERLEQELKQ IVKRSTTQVA DSAYQRGESL TVDNQPRLLL ELLELLFDKF
360 370 380 390 400
NAVATAHSVV LGYLQDSVGT QLTQQEEIKL YDMADVWVKI QDVLQMLLTE
410 420 430 440 450
YLDMKNTRTA SEPSAQLSYA STGREFAAFF AKKKPQRPKN SLFKFESSSH
460 470 480 490 500
AISMSAYLRE QRRELYSRSG ELQGGPDDNL IEGGGTKFVC KPGARNITVI
510 520 530 540 550
FHPLLRFIQE IEHALGLGPA KQCPLREFLT VYIKSIFLNQ VLAEINKEIE
560 570 580 590 600
GVTKTSDPLK ILANADTMKV LGVQRPLLQS TIIVEKTVQD LMNLMHDLSA
610 620 630 640 650
YSDQFLNMVC VKLQEYKDTC STAYRGIVQS EEKLVISASW AKDDDISRLL
660 670 680 690 700
KSLPNWTNMA QPKQLRPKRE EEEDFIRAAF GKESEVLIGN LGDKLIPPQD
710 720 730 740 750
ILRDVSDLKA LANMHESLEW LAGRTKSAFS NLSTSQMLSP AQESHVNMDL
760 770 780 790 800
PPVSEQIMQT LSELAKTFQD MADRCLLVLH LEVRVHCFHY LIPLAKEGNY
810 820 830 840 850
AIVANVESMD YDPLVVKLNK DISAMEEAMS ASLQQHKFQY IFEGLGHLIS
860 870 880 890 900
CILINGAQYF RRISESGIKK MCRNIFVLQQ NLTNITMSRE ADLDFARQYY
910 920 930 940 950
EMLYNTADEL LNLVVDQGVK YTELEYIHAL TLLHRSQTGV GDQTTQNTRL
960 970
QRLKEIICEQ AAIKQATKDK KITTV
Length:975
Mass (Da):110,545
Last modified:October 25, 2002 - v2
Checksum:i8DB5E154FA44E52A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CXE1Q9CXE1_MOUSE
Exocyst complex component 4
Exoc4 Sec8l1
522Annotation score:
Q8C391Q8C391_MOUSE
Exocyst complex component 4
Exoc4 Sec8l1
506Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti692G → A in AAB86537 (PubMed:9441674).Curated1
Sequence conflicti717S → R in AAB86537 (PubMed:9441674).Curated1
Sequence conflicti832S → T in AAB86537 (PubMed:9441674).Curated1
Sequence conflicti949 – 975RLQRL…KITTV → SCRDSRRSSVSRLPSSKPPR TRK in AAB86537 (PubMed:9441674).CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022962 mRNA Translation: AAB86537.1
BC034644 mRNA Translation: AAH34644.1
CCDSiCCDS19987.1
RefSeqiNP_033174.2, NM_009148.3
UniGeneiMm.265512

Genome annotation databases

EnsembliENSMUST00000052266; ENSMUSP00000051965; ENSMUSG00000029763
GeneIDi20336
KEGGimmu:20336
UCSCiuc009bgs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022962 mRNA Translation: AAB86537.1
BC034644 mRNA Translation: AAH34644.1
CCDSiCCDS19987.1
RefSeqiNP_033174.2, NM_009148.3
UniGeneiMm.265512

3D structure databases

ProteinModelPortaliO35382
SMRiO35382
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203152, 4 interactors
DIPiDIP-32368N
IntActiO35382, 11 interactors
MINTiO35382
STRINGi10090.ENSMUSP00000051965

PTM databases

iPTMnetiO35382
PhosphoSitePlusiO35382

Proteomic databases

EPDiO35382
MaxQBiO35382
PaxDbiO35382
PeptideAtlasiO35382
PRIDEiO35382

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052266; ENSMUSP00000051965; ENSMUSG00000029763
GeneIDi20336
KEGGimmu:20336
UCSCiuc009bgs.1 mouse

Organism-specific databases

CTDi60412
MGIiMGI:1096376 Exoc4

Phylogenomic databases

eggNOGiKOG3691 Eukaryota
ENOG410Z8N0 LUCA
GeneTreeiENSGT00390000001439
HOVERGENiHBG036151
InParanoidiO35382
KOiK06111
OMAiKEHRRNA
OrthoDBiEOG091G0QUY
TreeFamiTF313954

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRSiExoc4 mouse
PROiPR:O35382
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029763 Expressed in 290 organ(s), highest expression level in pituitary gland
CleanExiMM_EXOC4
ExpressionAtlasiO35382 baseline and differential
GenevisibleiO35382 MM

Family and domain databases

InterProiView protein in InterPro
IPR039682 Sec8/EXOC4
IPR007191 Sec8_exocyst
PANTHERiPTHR14146 PTHR14146, 1 hit
PfamiView protein in Pfam
PF04048 Sec8_exocyst, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC4_MOUSE
AccessioniPrimary (citable) accession number: O35382
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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