Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene

Anp32a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.1 Publication

GO - Molecular functioni

  • histone binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Alternative name(s):
Acidic nuclear phosphoprotein pp32
Leucine-rich acidic nuclear protein
Short name:
LANP
Potent heat-stable protein phosphatase 2A inhibitor I1PP2A
Gene namesi
Name:Anp32a
Synonyms:Anp32, Lanp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108447 Anp32a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile. They have no derangements in any of the major organ systems, including the nervous systems.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375931 – 247Acidic leucine-rich nuclear phosphoprotein 32 family member AAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphothreonineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei158PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues.By similarity
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35381
MaxQBiO35381
PaxDbiO35381
PeptideAtlasiO35381
PRIDEiO35381

2D gel databases

REPRODUCTION-2DPAGEiIPI00314736

PTM databases

iPTMnetiO35381
PhosphoSitePlusiO35381
SwissPalmiO35381

Expressioni

Tissue specificityi

Predominantly expressed in the cerebellum. Expressed also in cortex, lung, skeletal muscle, gastrointestinal tract, spleen, liver and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000032249 Expressed in 328 organ(s), highest expression level in cerebellum
ExpressionAtlasiO35381 baseline and differential
GenevisibleiO35381 MM

Interactioni

Subunit structurei

Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B. Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
E4f1Q8CCE92EBI-643140,EBI-7450874

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198104, 2 interactors
IntActiO35381, 12 interactors
MINTiO35381
STRINGi10090.ENSMUSP00000082652

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO35381
SMRiO35381
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35381

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 38LRR 1Add BLAST21
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 87LRR 3Add BLAST23
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 172Necessary for tumor-suppressive functionBy similarityAdd BLAST23
Regioni165 – 247Interaction with E4F11 PublicationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi165 – 247Asp/Glu-rich (highly acidic)Add BLAST83

Sequence similaritiesi

Belongs to the ANP32 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
GeneTreeiENSGT00560000077130
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiO35381
KOiK18646
OMAiDCNDEEA
OrthoDBiEOG091G0R8Z
PhylomeDBiO35381
TreeFamiTF317206

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O35381-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMDKRIYLE LRNRTPSDVK ELVLDNCKSI EGKIEGLTDE FEELEFLSTI
60 70 80 90 100
NVGLTSISNL PKLNKLKKLE LSENRISGDL EVLAEKCPNL KHLNLSGNKI
110 120 130 140 150
KDLSTIEPLK KLENLKSLDL FNCEVTNLNA YRENVFKLLP QVMYLDGYDR
160 170 180 190 200
DNKEAPDSDV EGYVEDDDEE DEDEEEYDEY AQLVEDEEEE DEEEEGEEED
210 220 230 240
VSGEEEEDEE GYNDGEVDDE EDEEEAGEEE GSQKRKREPD DEGEEDD
Length:247
Mass (Da):28,538
Last modified:January 1, 1998 - v1
Checksum:i82EEDCF72ECC2918
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7M9D3Z7M9_MOUSE
Acidic leucine-rich nuclear phospho...
Anp32a
233Annotation score:
D3YYE1D3YYE1_MOUSE
Acidic leucine-rich nuclear phospho...
Anp32a
198Annotation score:
F6UFG6F6UFG6_MOUSE
Acidic leucine-rich nuclear phospho...
Anp32a
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191D → V in AAB39707 (PubMed:8970164).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73478 mRNA Translation: AAB39707.1
AF022957 mRNA Translation: AAB91546.1
BC062899 mRNA Translation: AAH62899.1
CCDSiCCDS40663.1
RefSeqiNP_033802.2, NM_009672.3
UniGeneiMm.269088

Genome annotation databases

EnsembliENSMUST00000085519; ENSMUSP00000082652; ENSMUSG00000032249
GeneIDi11737
KEGGimmu:11737
UCSCiuc009qah.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73478 mRNA Translation: AAB39707.1
AF022957 mRNA Translation: AAB91546.1
BC062899 mRNA Translation: AAH62899.1
CCDSiCCDS40663.1
RefSeqiNP_033802.2, NM_009672.3
UniGeneiMm.269088

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JQDNMR-A1-164[»]
ProteinModelPortaliO35381
SMRiO35381
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198104, 2 interactors
IntActiO35381, 12 interactors
MINTiO35381
STRINGi10090.ENSMUSP00000082652

PTM databases

iPTMnetiO35381
PhosphoSitePlusiO35381
SwissPalmiO35381

2D gel databases

REPRODUCTION-2DPAGEiIPI00314736

Proteomic databases

EPDiO35381
MaxQBiO35381
PaxDbiO35381
PeptideAtlasiO35381
PRIDEiO35381

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085519; ENSMUSP00000082652; ENSMUSG00000032249
GeneIDi11737
KEGGimmu:11737
UCSCiuc009qah.3 mouse

Organism-specific databases

CTDi8125
MGIiMGI:108447 Anp32a

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
GeneTreeiENSGT00560000077130
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiO35381
KOiK18646
OMAiDCNDEEA
OrthoDBiEOG091G0R8Z
PhylomeDBiO35381
TreeFamiTF317206

Enzyme and pathway databases

ReactomeiR-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA

Miscellaneous databases

ChiTaRSiAnp32a mouse
EvolutionaryTraceiO35381
PROiPR:O35381
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032249 Expressed in 328 organ(s), highest expression level in cerebellum
ExpressionAtlasiO35381 baseline and differential
GenevisibleiO35381 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAN32A_MOUSE
AccessioniPrimary (citable) accession number: O35381
Secondary accession number(s): P97437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again