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Protein

Neuropilin-2

Gene

Nrp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi197CalciumBy similarity1
Metal bindingi211CalciumBy similarity1
Metal bindingi252CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Receptor
Biological processDifferentiation, Neurogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194306 Neurophilin interactions with VEGF and VEGFR

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuropilin-2
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1100492 Nrp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 864ExtracellularSequence analysisAdd BLAST844
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei865 – 889HelicalSequence analysisAdd BLAST25
Topological domaini890 – 931CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002186421 – 931Neuropilin-2Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 55By similarity
Disulfide bondi83 ↔ 105By similarity
Disulfide bondi149 ↔ 175By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi208 ↔ 230By similarity
Disulfide bondi277 ↔ 427By similarity
Disulfide bondi434 ↔ 592By similarity
Glycosylationi629N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi839N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O35375

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O35375

PeptideAtlas

More...
PeptideAtlasi
O35375

PRoteomics IDEntifications database

More...
PRIDEi
O35375

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O35375

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O35375

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O35375

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in developing CNS, PNS and in some nonneural tissues including limb buds, developing bones, muscles, intestinal epithelium, kidney, lung and submandibular gland.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

The expression pattern is very dynamic and is developmentally regulated.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025969 Expressed in 266 organ(s), highest expression level in vault of skull

CleanEx database of gene expression profiles

More...
CleanExi
MM_NRP2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O35375 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O35375 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with NRP1. Binds PLXNB1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201849, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109794

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O35375

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O35375

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 142CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 267CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini277 – 427F5/8 type C 1PROSITE-ProRule annotationAdd BLAST151
Domaini434 – 592F5/8 type C 2PROSITE-ProRule annotationAdd BLAST159
Domaini642 – 802MAMPROSITE-ProRule annotationAdd BLAST161

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi838 – 845Poly-Ser8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neuropilin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHB5 Eukaryota
ENOG410ZPIE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155270

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000502

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O35375

KEGG Orthology (KO)

More...
KOi
K06819

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCNFDLP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01LI

TreeFam database of animal gene trees

More...
TreeFami
TF316506

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 2 hits
cd00057 FA58C, 2 hits
cd06263 MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR027143 Neuropilin-2
IPR022579 Neuropilin_C
IPR035914 Sperma_CUB_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR44185 PTHR44185, 1 hit
PTHR44185:SF2 PTHR44185:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036960 Neuropilin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00020 MAMDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS50060 MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A22 (identifier: O35375-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDMFPLTWVF LALYFSGHEV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP
60 70 80 90 100
SHQNCEWIVY APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL
110 120 130 140 150
LGKHCGNIAP PTIISSGSVL YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS
160 170 180 190 200
KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL AKPRMEIILQ FLTFDLEHDP
210 220 230 240 250
LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS STGILSLTFH
260 270 280 290 300
TDMAVAKDGF SARYYLIHQE PPENFQCNVP LGMESGRIAN EQISASSTFS
310 320 330 340 350
DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR
360 370 380 390 400
ETQKGYYVKS YKLEVSTNGE DWMVYRHGKN HKIFQANNDA TEVVLNKLHM
410 420 430 440 450
PLLTRFIRIR PQTWHLGIAL RLELFGCRVT DAPCSNMLGM LSGLIADTQI
460 470 480 490 500
SASSTREYLW SPSAARLVSS RSGWFPRNPQ AQPGEEWLQV DLGTPKTVKG
510 520 530 540 550
VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD PRTQQTKLFE
560 570 580 590 600
GNMHYDTPDI RRFDPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT
610 620 630 640 650
VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF
660 670 680 690 700
PEETCGWVYD HAKWLRSTWI SSANPNDRTF PDDKNFLKLQ SDGRREGQYG
710 720 730 740 750
RLISPPVHLP RSPVCMEFQY QAMGGHGVAL QVVREASQES KLLWVIREDQ
760 770 780 790 800
GSEWKHGRII LPSYDMEYQI VFEGVIGKGR SGEISIDDIR ISTDVPLENC
810 820 830 840 850
MEPISAFAGE DFKVDIPETH GGEGYEDEID DEYEGDWSNS SSSTSGAGDP
860 870 880 890 900
SSGKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR
910 920 930
SCTTLENYNF ELYDGLKHKV KINHQKCCSE A
Length:931
Mass (Da):104,631
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08AA821E696A2885
GO
Isoform A0 (identifier: O35375-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-830: Missing.

Show »
Length:909
Mass (Da):102,198
Checksum:iA34352A52526A136
GO
Isoform A5 (identifier: O35375-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     814-830: Missing.

Show »
Length:914
Mass (Da):102,775
Checksum:i6EA486DAB152F20B
GO
Isoform A17 (identifier: O35375-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.

Show »
Length:926
Mass (Da):104,055
Checksum:i8073D6478C9A8467
GO
Isoform B0 (identifier: O35375-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-931: EDFKVDIPET...INHQKCCSEA → GTLPPGTEPT...KLEQERGSHC

Show »
Length:901
Mass (Da):101,418
Checksum:iF763734C2A09F52F
GO
Isoform B5 (identifier: O35375-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     814-931: VDIPETHGGE...INHQKCCSEA → GGTLPPGTEP...KLEQERGSHC

Show »
Length:906
Mass (Da):101,995
Checksum:i6D66AF632D47A21F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32L → P in AAC53377 (PubMed:9331348).Curated1
Sequence conflicti32L → P in AAC53378 (PubMed:9331348).Curated1
Sequence conflicti32L → P in AAC53379 (PubMed:9331348).Curated1
Sequence conflicti32L → P in AAC53380 (PubMed:9331348).Curated1
Sequence conflicti32L → P in AAC53381 (PubMed:9331348).Curated1
Sequence conflicti32L → P in AAC53382 (PubMed:9331348).Curated1
Sequence conflicti786I → G in AAC53377 (PubMed:9331348).Curated1
Sequence conflicti786I → G in AAC53378 (PubMed:9331348).Curated1
Sequence conflicti786I → G in AAC53382 (PubMed:9331348).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004344809 – 830Missing in isoform A0. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_004343809 – 813Missing in isoform A17. 1 Publication5
Alternative sequenceiVSP_004346810 – 931EDFKV…CCSEA → GTLPPGTEPTVDTVPVQPIP AYWYYVMAAGGAVLVLASVV LALVLHYHRFRYAAKKTDHS ITYKTSHYTNGAPLAVEPTL TIKLEQERGSHC in isoform B0. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_004347814 – 931VDIPE…CCSEA → GGTLPPGTEPTVDTVPVQPI PAYWYYVMAAGGAVLVLASV VLALVLHYHRFRYAAKKTDH SITYKTSHYTNGAPLAVEPT LTIKLEQERGSHC in isoform B5. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_004345814 – 830Missing in isoform A5. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF022856 mRNA Translation: AAC53379.1
AF022854 mRNA Translation: AAC53377.1
AF022855 mRNA Translation: AAC53378.1
AF022857 mRNA Translation: AAC53380.1
AF022858 mRNA Translation: AAC53381.1
AF022861 mRNA Translation: AAC53382.1
AL671560, AL645727 Genomic DNA Translation: CAI24156.1
AL645727, AL671560 Genomic DNA Translation: CAI24511.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14995.1 [O35375-3]
CCDS35589.1 [O35375-1]
CCDS35590.1 [O35375-4]
CCDS35591.1 [O35375-2]
CCDS35592.1 [O35375-6]
CCDS35593.1 [O35375-5]

NCBI Reference Sequences

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RefSeqi
NP_001070871.1, NM_001077403.1 [O35375-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.266341

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000027112; ENSMUSP00000027112; ENSMUSG00000025969 [O35375-6]
ENSMUST00000063594; ENSMUSP00000069379; ENSMUSG00000025969 [O35375-4]
ENSMUST00000075144; ENSMUSP00000074642; ENSMUSG00000025969 [O35375-3]
ENSMUST00000102822; ENSMUSP00000099886; ENSMUSG00000025969 [O35375-2]
ENSMUST00000114155; ENSMUSP00000109792; ENSMUSG00000025969 [O35375-5]
ENSMUST00000114157; ENSMUSP00000109794; ENSMUSG00000025969 [O35375-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18187

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18187

UCSC genome browser

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UCSCi
uc007bfj.1 mouse [O35375-6]
uc007bfl.1 mouse [O35375-1]
uc007bfn.1 mouse [O35375-3]
uc007bfo.1 mouse [O35375-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022856 mRNA Translation: AAC53379.1
AF022854 mRNA Translation: AAC53377.1
AF022855 mRNA Translation: AAC53378.1
AF022857 mRNA Translation: AAC53380.1
AF022858 mRNA Translation: AAC53381.1
AF022861 mRNA Translation: AAC53382.1
AL671560, AL645727 Genomic DNA Translation: CAI24156.1
AL645727, AL671560 Genomic DNA Translation: CAI24511.1
CCDSiCCDS14995.1 [O35375-3]
CCDS35589.1 [O35375-1]
CCDS35590.1 [O35375-4]
CCDS35591.1 [O35375-2]
CCDS35592.1 [O35375-6]
CCDS35593.1 [O35375-5]
RefSeqiNP_001070871.1, NM_001077403.1 [O35375-1]
UniGeneiMm.266341

3D structure databases

ProteinModelPortaliO35375
SMRiO35375
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201849, 2 interactors
STRINGi10090.ENSMUSP00000109794

PTM databases

iPTMnetiO35375
PhosphoSitePlusiO35375
SwissPalmiO35375

Proteomic databases

MaxQBiO35375
PaxDbiO35375
PeptideAtlasiO35375
PRIDEiO35375

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027112; ENSMUSP00000027112; ENSMUSG00000025969 [O35375-6]
ENSMUST00000063594; ENSMUSP00000069379; ENSMUSG00000025969 [O35375-4]
ENSMUST00000075144; ENSMUSP00000074642; ENSMUSG00000025969 [O35375-3]
ENSMUST00000102822; ENSMUSP00000099886; ENSMUSG00000025969 [O35375-2]
ENSMUST00000114155; ENSMUSP00000109792; ENSMUSG00000025969 [O35375-5]
ENSMUST00000114157; ENSMUSP00000109794; ENSMUSG00000025969 [O35375-1]
GeneIDi18187
KEGGimmu:18187
UCSCiuc007bfj.1 mouse [O35375-6]
uc007bfl.1 mouse [O35375-1]
uc007bfn.1 mouse [O35375-3]
uc007bfo.1 mouse [O35375-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8828
MGIiMGI:1100492 Nrp2

Phylogenomic databases

eggNOGiENOG410IHB5 Eukaryota
ENOG410ZPIE LUCA
GeneTreeiENSGT00940000155270
HOVERGENiHBG000502
InParanoidiO35375
KOiK06819
OMAiNCNFDLP
OrthoDBiEOG091G01LI
TreeFamiTF316506

Enzyme and pathway databases

ReactomeiR-MMU-194306 Neurophilin interactions with VEGF and VEGFR

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nrp2 mouse

Protein Ontology

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PROi
PR:O35375

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025969 Expressed in 266 organ(s), highest expression level in vault of skull
CleanExiMM_NRP2
ExpressionAtlasiO35375 baseline and differential
GenevisibleiO35375 MM

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00057 FA58C, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR027143 Neuropilin-2
IPR022579 Neuropilin_C
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR44185 PTHR44185, 1 hit
PTHR44185:SF2 PTHR44185:SF2, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
PRINTSiPR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS50060 MAM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35375
Secondary accession number(s): B1AT44
, O35373, O35374, O35376, O35377, O35378
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: December 5, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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