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Protein

Protein cornichon homolog 1

Gene

Cnih1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the selective transport and maturation of TGF-alpha family proteins.By similarity

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 1
Short name:
CNIH-1
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 1
Protein cornichon homolog
Gene namesi
Name:Cnih1
Synonyms:Cnih
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1277202 Cnih1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 56LumenalSequence analysisAdd BLAST25
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 122CytoplasmicSequence analysisAdd BLAST45
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144LumenalSequence analysis1

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222231 – 144Protein cornichon homolog 1Add BLAST144

Proteomic databases

PaxDbiO35372
PeptideAtlasiO35372
PRIDEiO35372

Expressioni

Tissue specificityi

Expressed in oocytes, and at a basal level in ovarian somatic cells of 6-week-old mouse. Expressed in adult brain.

Developmental stagei

Abundant in full grown oocyte and the ovulated unfertilized egg, shows a slight decrease 12 hours after fertilization. Transcripts from the activated embryonic genome are present in the eight-cell embryo.

Gene expression databases

BgeeiENSMUSG00000015759 Expressed in 316 organ(s), highest expression level in maxillary prominence
CleanExiMM_CNIH
ExpressionAtlasiO35372 baseline and differential
GenevisibleiO35372 MM

Interactioni

Subunit structurei

Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015903

Structurei

3D structure databases

ProteinModelPortaliO35372
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2729 Eukaryota
ENOG4111MWH LUCA
GeneTreeiENSGT00390000015751
HOGENOMiHOG000214661
HOVERGENiHBG003814
InParanoidiO35372
KOiK20368
OMAiAFSYIVA
OrthoDBiEOG091G0KIX
TreeFamiTF300083

Family and domain databases

InterProiView protein in InterPro
IPR003377 Cornichon
IPR033466 Cornichon_conserved
PfamiView protein in Pfam
PF03311 Cornichon, 1 hit
SMARTiView protein in SMART
SM01398 Cornichon, 1 hit
PROSITEiView protein in PROSITE
PS01340 CORNICHON, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35372-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP
60 70 80 90 100
LVLPEYLIHA FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL
110 120 130 140
YDPTTIMNAD ILAYCQKEGW CKLAFYLLAF FYYLYGMIYV LVSS
Length:144
Mass (Da):16,699
Last modified:October 3, 2012 - v2
Checksum:i59BD114D24C455CD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGU4D6RGU4_MOUSE
Protein cornichon homolog 1
Cnih1 Cnih
160Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97G → A in AAC15828 (PubMed:10022955).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022811 mRNA Translation: AAC15828.1
AK002293 mRNA Translation: BAB21993.1
AK011200 mRNA Translation: BAB27463.1
AK152432 mRNA Translation: BAE31214.1
AC093043 Genomic DNA No translation available.
CH466605 Genomic DNA Translation: EDL20721.1
BC034868 mRNA Translation: AAH34868.1
CCDSiCCDS26980.1
RefSeqiNP_034049.2, NM_009919.2
UniGeneiMm.3261

Genome annotation databases

EnsembliENSMUST00000015903; ENSMUSP00000015903; ENSMUSG00000015759
GeneIDi12793
KEGGimmu:12793
UCSCiuc007thg.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022811 mRNA Translation: AAC15828.1
AK002293 mRNA Translation: BAB21993.1
AK011200 mRNA Translation: BAB27463.1
AK152432 mRNA Translation: BAE31214.1
AC093043 Genomic DNA No translation available.
CH466605 Genomic DNA Translation: EDL20721.1
BC034868 mRNA Translation: AAH34868.1
CCDSiCCDS26980.1
RefSeqiNP_034049.2, NM_009919.2
UniGeneiMm.3261

3D structure databases

ProteinModelPortaliO35372
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015903

Proteomic databases

PaxDbiO35372
PeptideAtlasiO35372
PRIDEiO35372

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015903; ENSMUSP00000015903; ENSMUSG00000015759
GeneIDi12793
KEGGimmu:12793
UCSCiuc007thg.3 mouse

Organism-specific databases

CTDi10175
MGIiMGI:1277202 Cnih1

Phylogenomic databases

eggNOGiKOG2729 Eukaryota
ENOG4111MWH LUCA
GeneTreeiENSGT00390000015751
HOGENOMiHOG000214661
HOVERGENiHBG003814
InParanoidiO35372
KOiK20368
OMAiAFSYIVA
OrthoDBiEOG091G0KIX
TreeFamiTF300083

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER

Miscellaneous databases

PROiPR:O35372
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015759 Expressed in 316 organ(s), highest expression level in maxillary prominence
CleanExiMM_CNIH
ExpressionAtlasiO35372 baseline and differential
GenevisibleiO35372 MM

Family and domain databases

InterProiView protein in InterPro
IPR003377 Cornichon
IPR033466 Cornichon_conserved
PfamiView protein in Pfam
PF03311 Cornichon, 1 hit
SMARTiView protein in SMART
SM01398 Cornichon, 1 hit
PROSITEiView protein in PROSITE
PS01340 CORNICHON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNIH1_MOUSE
AccessioniPrimary (citable) accession number: O35372
Secondary accession number(s): Q6ZWW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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