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Protein

Acetylcholinesterase collagenic tail peptide

Gene

Colq

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.By similarity

GO - Molecular functioni

  • extracellular matrix structural constituent Source: BHF-UCL
  • heparin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processNeurotransmitter degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase collagenic tail peptide
Alternative name(s):
AChE Q subunit
Acetylcholinesterase-associated collagen
Gene namesi
Name:Colq
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1338761 Colq

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000005941530 – 457Acetylcholinesterase collagenic tail peptideAdd BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51Interchain (with T subunit)Sequence analysis
Disulfide bondi52Interchain (with T subunit)Sequence analysis
Disulfide bondi92InterchainSequence analysis
Disulfide bondi293InterchainSequence analysis
Disulfide bondi295InterchainSequence analysis

Post-translational modificationi

The triple-helical tail is stabilized by disulfide bonds at each end.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO35348
PaxDbiO35348
PRIDEiO35348

PTM databases

PhosphoSitePlusiO35348

Expressioni

Gene expression databases

BgeeiENSMUSG00000057606 Expressed in 24 organ(s), highest expression level in thymus
ExpressionAtlasiO35348 baseline and differential

Interactioni

Subunit structurei

Homotrimer. Component of the asymmetric form of AChE, a disulfide-bonded oligomer composed of the collagenic subunits (Q) and a variable number of asymmetric catalytic subunits (T). The N-terminal of a collagenic subunit (Q) associates with the C-terminal of a catalytic subunit (T) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107658

Structurei

3D structure databases

ProteinModelPortaliO35348
SMRiO35348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 154Collagen-like 1Add BLAST60
Domaini158 – 271Collagen-like 2Add BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 67PRADBy similarityAdd BLAST17
Regioni129 – 132Heparan sulfate proteoglycan bindingSequence analysis4
Regioni234 – 237Heparan sulfate proteoglycan bindingSequence analysis4

Domaini

The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits.By similarity

Sequence similaritiesi

Belongs to the COLQ family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IS7G Eukaryota
ENOG410XS2Q LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000085655
HOVERGENiHBG102052
InParanoidiO35348
OMAiHKGVEDC
OrthoDBiEOG091G0CAQ
PhylomeDBiO35348
TreeFamiTF331890

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR011936 Myxo_disulph_rpt
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
TIGRFAMsiTIGR02232 myxo_disulf_rpt, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVLNPMTLG IYLQLFFCSI VSQPTFINSV VPISAALPGL DQKKRGSHKA
60 70 80 90 100
CCLLMPPPPP LFPPPFFRGS RSPLLSPDMK NLLELEASPS PCIQGSLGSP
110 120 130 140 150
GPPGPQGPPG LPGKTGPKGE KGDLGRPGRK GRPGPPGVPG MPGPVGWPGP
160 170 180 190 200
EGPRGEKGDL GMMGLPGSRG PMGSKGFPGS RGEKGSRGER GDLGPKGEKG
210 220 230 240 250
FPGFPGMLGQ KGEMGPKGES GLAGHRGPTG RPGKRGKQGQ KGDSGIMGPP
260 270 280 290 300
GKPGPSGQPG RQGPPGPPGP PSAGQLVMGL KGERGFPGPP GRCLCGPPVN
310 320 330 340 350
VNNPSYGDSM YGRGSPRVPA IFVVNNQEEL ERLNTQNAIA FRRDQRSLYF
360 370 380 390 400
KDSLGWLPIQ LTPFYPVGYT VKQPGTCGDG VLQPGEECDD GNPDVSDGCI
410 420 430 440 450
DCHRAYCGDG YRHQGVEDCD GSDFGYLTCE TYLPGSYGDL RCTQYCSIDS

TPCRYFT
Length:457
Mass (Da):47,684
Last modified:January 9, 2007 - v2
Checksum:i461E93C3DB0162B2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PVR3E9PVR3_MOUSE
Acetylcholinesterase collagenic tai...
Colq
447Annotation score:
D3Z1C2D3Z1C2_MOUSE
Acetylcholinesterase collagenic tai...
Colq
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105Missing in AAB72195 (PubMed:9278446).Curated1
Sequence conflicti250P → H in AAB72195 (PubMed:9278446).Curated1
Sequence conflicti267P → A in AAB72195 (PubMed:9278446).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107386 mRNA Translation: AAI07387.1
AH005576 Genomic DNA Translation: AAB72195.1
CCDSiCCDS36856.2
RefSeqiNP_034067.2, NM_009937.2
UniGeneiMm.239821

Genome annotation databases

EnsembliENSMUST00000112027; ENSMUSP00000107658; ENSMUSG00000057606
GeneIDi382864
KEGGimmu:382864
UCSCiuc007sxv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107386 mRNA Translation: AAI07387.1
AH005576 Genomic DNA Translation: AAB72195.1
CCDSiCCDS36856.2
RefSeqiNP_034067.2, NM_009937.2
UniGeneiMm.239821

3D structure databases

ProteinModelPortaliO35348
SMRiO35348
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107658

PTM databases

PhosphoSitePlusiO35348

Proteomic databases

MaxQBiO35348
PaxDbiO35348
PRIDEiO35348

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112027; ENSMUSP00000107658; ENSMUSG00000057606
GeneIDi382864
KEGGimmu:382864
UCSCiuc007sxv.2 mouse

Organism-specific databases

CTDi8292
MGIiMGI:1338761 Colq

Phylogenomic databases

eggNOGiENOG410IS7G Eukaryota
ENOG410XS2Q LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000085655
HOVERGENiHBG102052
InParanoidiO35348
OMAiHKGVEDC
OrthoDBiEOG091G0CAQ
PhylomeDBiO35348
TreeFamiTF331890

Miscellaneous databases

PROiPR:O35348
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057606 Expressed in 24 organ(s), highest expression level in thymus
ExpressionAtlasiO35348 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR011936 Myxo_disulph_rpt
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
TIGRFAMsiTIGR02232 myxo_disulf_rpt, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOLQ_MOUSE
AccessioniPrimary (citable) accession number: O35348
Secondary accession number(s): Q08EK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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