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Protein

Protein DGCR6

Gene

Dgcr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in early embryogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DGCR6
Alternative name(s):
DiGeorge syndrome critical region 6 homolog
Gene namesi
Name:Dgcr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1202877 Dgcr6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702611 – 198Protein DGCR6Add BLAST198

Proteomic databases

MaxQBiO35347
PaxDbiO35347
PeptideAtlasiO35347
PRIDEiO35347

PTM databases

PhosphoSitePlusiO35347

Expressioni

Tissue specificityi

Expressed in all the examined tissues with highest expression in testis.

Developmental stagei

Expressed in early embryogenesis. Found in the peripheral and central nervous systems.

Gene expression databases

CleanExiMM_DGCR6

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076044

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 142Sequence analysisAdd BLAST65

Sequence similaritiesi

Belongs to the gonadal family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4810 Eukaryota
ENOG4111RN8 LUCA
HOGENOMiHOG000006852
HOVERGENiHBG051343
InParanoidiO35347

Family and domain databases

InterProiView protein in InterPro
IPR010849 Gonadal
PANTHERiPTHR13054 PTHR13054, 1 hit
PfamiView protein in Pfam
PF07324 DGCR6, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O35347-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRYAAAGDE AADRARQQER HYQLLSALQS LVKELPSSFQ QRLSYTTLSD
60 70 80 90 100
LALALLDGTV FEIVQGLLEI QHLTEKSLYN QRLRLQNEHR VLRQTLRQKH
110 120 130 140 150
LEAQQSCRPH NLPVLQAAQQ RELEAMEHRI REEQQAMDRK IVLELDRKVA
160 170 180 190
DQQSTLEKAG VAGFYVTTNP QELTLQMNLL ELIRKLQQRS CQVGKAAL
Length:198
Mass (Da):22,837
Last modified:May 30, 2000 - v2
Checksum:i4767591BA0A95F14
GO
Isoform 2 (identifier: O35347-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     29-36: QSLVKELP → MVESMAPA

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):19,570
Checksum:i35E542DE1C6381CC
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z558D3Z558_MOUSE
Protein DGCR6
Dgcr6
198Annotation score:
Q3TV71Q3TV71_MOUSE
Protein DGCR6
Dgcr6
170Annotation score:
E9QP31E9QP31_MOUSE
Protein DGCR6
Dgcr6
201Annotation score:
D3YUN0D3YUN0_MOUSE
Protein DGCR6
Dgcr6
233Annotation score:
F6W2M9F6W2M9_MOUSE
Protein DGCR6
Dgcr6
119Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190S → G in BAB31671 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0018271 – 28Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_00182829 – 36QSLVKELP → MVESMAPA in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021031 mRNA Translation: AAB82548.1
AK019346 mRNA Translation: BAB31671.1
CCDSiCCDS28016.1 [O35347-2]
CCDS79433.1 [O35347-1]
RefSeqiNP_001276742.1, NM_001289813.1
NP_034177.1, NM_010047.4
UniGeneiMm.27155

Genome annotation databases

GeneIDi13353
KEGGimmu:13353

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021031 mRNA Translation: AAB82548.1
AK019346 mRNA Translation: BAB31671.1
CCDSiCCDS28016.1 [O35347-2]
CCDS79433.1 [O35347-1]
RefSeqiNP_001276742.1, NM_001289813.1
NP_034177.1, NM_010047.4
UniGeneiMm.27155

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076044

PTM databases

PhosphoSitePlusiO35347

Proteomic databases

MaxQBiO35347
PaxDbiO35347
PeptideAtlasiO35347
PRIDEiO35347

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13353
KEGGimmu:13353

Organism-specific databases

CTDi8214
MGIiMGI:1202877 Dgcr6

Phylogenomic databases

eggNOGiKOG4810 Eukaryota
ENOG4111RN8 LUCA
HOGENOMiHOG000006852
HOVERGENiHBG051343
InParanoidiO35347

Miscellaneous databases

ChiTaRSiDgcr6 mouse
PROiPR:O35347
SOURCEiSearch...

Gene expression databases

CleanExiMM_DGCR6

Family and domain databases

InterProiView protein in InterPro
IPR010849 Gonadal
PANTHERiPTHR13054 PTHR13054, 1 hit
PfamiView protein in Pfam
PF07324 DGCR6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDGCR6_MOUSE
AccessioniPrimary (citable) accession number: O35347
Secondary accession number(s): Q9D2P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 5, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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